BCL2/IGH (t14;18) Test
Short Name: BCL2/IGH
Also known as: t(14;18) translocation, BCL2/IGH rearrangement, Follicular lymphoma FISH
BCL2/IGH (t14;18) Test test available at DNA Labs India for ₹9,000. Uses FISH (Fluorescence In Situ Hybridization) on Tumor tissue (paraffin-embedded block) samples. Results in Results are typically available within 7-8 days after the laboratory receives the sample.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the BCL2/IGH (t14;18) test is to detect the presence of the t(14;18) translocation, which is characteristic of follicular lymphoma. This test aids in: 1) Confirming the diagnosis of follicular lymphoma, 2) Differentiating it from other types of lymphoma, 3) Assessing the risk of disease progression, 4) Monitoring response to therapy, 5) Detecting minimal residual disease, and 6) Providing prognostic information for treatment planning.
- Test Code
- 6041
- CPT Code
- 88271, 88275
- ICD Code
- C82.9
- Price
- ₹9,000
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Results are typically available within 7-8 days after the laboratory receives the sample.
- Fasting Required
- No
- Method
- FISH (Fluorescence In Situ Hybridization)
Sample Collection
No special preparation is required. A doctor's prescription is necessary. Inform your doctor about any medications you are taking.
Method: Biopsy (surgical or core needle)
Laboratory Analysis
The sample is collected via a biopsy procedure (lymph node or bone marrow). Local anesthesia may be used. The procedure is performed by a qualified healthcare professional.
Report Delivery
After the biopsy, you may experience mild soreness or bruising at the site. Follow your doctor's instructions for wound care. You can resume normal activities unless advised otherwise.
Timeline: Results are typically available within 7-8 days after the laboratory receives the sample.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the BCL2/IGH (t14;18) test is to detect the presence of the t(14;18) translocation, which is characteristic of follicular lymphoma. This test aids in: 1) Confirming the diagnosis of follicular lymphoma, 2) Differentiating it from other types of lymphoma, 3) Assessing the risk of disease progression, 4) Monitoring response to therapy, 5) Detecting minimal residual disease, and 6) Providing prognostic information for treatment planning.
How to Prepare
- A doctor's prescription is mandatory.
- The biopsy must be performed by a trained professional.
- The tissue sample should be placed in a sterile container with appropriate fixative (e.g., formalin).
- The sample should be transported to the laboratory at ambient temperature.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The BCL2/IGH translocation is a hallmark of follicular lymphoma, present in up to 85% of cases. Early detection through FISH testing can guide targeted therapy and improve prognosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate tissue sample (less than 5 mm)
- Sample with extensive necrosis
- Sample not properly fixed
- Sample without proper labeling
Understanding Your Results
Positive
Detection of BCL2/IGH translocation is consistent with follicular lymphoma. It supports the diagnosis and may indicate a more indolent course. Further clinical correlation is required.
Negative
No BCL2/IGH translocation detected. This does not rule out follicular lymphoma, as a subset of cases may lack this translocation. Additional testing may be needed.
If you have symptoms suggestive of lymphoma, such as persistent lymph node swelling, unexplained fever, night sweats, or weight loss, consult an oncologist or hematologist promptly. Early diagnosis and treatment are crucial.
Limitations
- ⚠The test is specific for t(14;18) and may not detect other translocations
- ⚠A negative result does not completely rule out follicular lymphoma
- ⚠Requires adequate tumor tissue for accurate analysis
- ⚠Results should be interpreted in conjunction with histopathology and clinical findings
Risks & Considerations
- ●Bleeding at biopsy site
- ●Infection
- ●Pain or discomfort
- ●Rare risk of injury to surrounding structures
Interfering Factors
- ●Inadequate tissue sample
- ●Poor DNA quality due to prolonged fixation
- ●Decalcification of bone marrow samples
- ●Presence of necrosis in the tissue
Compare With Similar Tests
| Test | BCL2/IGH (t14;18) | BCL2/IGH (t14;18) FISH | Immunohistochemistry (IHC) | Flow Cytometry | PCR for BCL2/IGH |
|---|---|---|---|---|---|
| Comparison | BCL2/IGH (t14;18) |
Frequently Asked Questions
What is the BCL2/IGH (t14;18) test?
How is the test performed?
What is the cost of the test?
Is fasting required?
How long does it take to get results?
What does a positive result mean?
Can a negative result rule out lymphoma?
Is home sample collection available?
Do I need a doctor's prescription?
What is the sample type?
Are there any risks associated with the biopsy?
Can this test be done during pregnancy?
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