BCL6 Test
Also known as: BCL6 gene rearrangement, BCL6 FISH test
BCL6 Test test available at DNA Labs India for ₹6,000. Uses FISH (Fluorescence In Situ Hybridization) on Bone Marrow / Peripheral blood samples. Results in Reports are typically available within 5-6 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the BCL6 test is to detect genetic abnormalities in the BCL6 gene, which are often present in aggressive lymphomas. This information helps in confirming the diagnosis, determining the subtype of lymphoma, assessing prognosis, and guiding targeted therapy decisions. It is also useful in monitoring disease progression and response to treatment.
- Test Code
- 6040
- CPT Code
- 88271
- ICD Code
- C85.9
- Price
- ₹6,000
- Sample Type
- Bone Marrow / Peripheral blood
- Result Time
- Reports are typically available within 5-6 days after sample collection.
- Fasting Required
- No
- Method
- FISH (Fluorescence In Situ Hybridization)
Sample Collection
No special preparation required. A doctor's prescription is necessary. Inform your doctor about any medications you are taking.
Method: Venipuncture or bone marrow aspiration
Laboratory Analysis
A blood sample will be drawn from a vein in your arm, or a bone marrow biopsy may be performed under local anesthesia.
Report Delivery
You can resume normal activities immediately. If a bone marrow biopsy was done, you may experience soreness at the site, which should resolve within a few days.
Timeline: Reports are typically available within 5-6 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the BCL6 test is to detect genetic abnormalities in the BCL6 gene, which are often present in aggressive lymphomas. This information helps in confirming the diagnosis, determining the subtype of lymphoma, assessing prognosis, and guiding targeted therapy decisions. It is also useful in monitoring disease progression and response to treatment.
How to Prepare
- Bring a valid doctor's prescription
- No fasting required
- Wear comfortable clothing for easy access to the arm
- Inform the technician if you have a bleeding disorder or are on blood thinners
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"BCL6 gene rearrangement is a key marker in diagnosing aggressive lymphomas. Early detection through FISH testing can guide targeted therapy and improve outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed sample
- Incorrect container
- Insufficient sample volume
- Sample not stored at appropriate temperature
Understanding Your Results
Negative
No BCL6 rearrangement detected. This suggests a lower likelihood of BCL6-associated lymphoma, but other genetic abnormalities may be present.
Positive
BCL6 rearrangement detected. This is commonly seen in DLBCL, FL, and BL. The oncologist will use this information to guide treatment, which may include targeted therapies.
Consult your doctor if you experience persistent symptoms such as swollen lymph nodes, unexplained fever, night sweats, or weight loss. Early diagnosis and treatment are crucial for better outcomes.
Limitations
- ⚠FISH only detects specific known rearrangements; other mutations may not be identified
- ⚠Results should be interpreted in conjunction with clinical findings and other tests
- ⚠Test may not be informative in all cases of lymphoma
Risks & Considerations
- ●Minimal risk of bleeding or infection at the blood draw site
- ●Bone marrow biopsy may cause temporary pain or discomfort
- ●Rare risk of nerve damage during bone marrow aspiration
Interfering Factors
- ●Recent chemotherapy or radiation therapy may affect test results
- ●Inadequate sample volume or improper handling
- ●Presence of other genetic abnormalities
Compare With Similar Tests
| Test | BCL6 | BCL2 FISH | MYC FISH | IGH-BCL2 FISH |
|---|---|---|---|---|
| Comparison | BCL6 |
Frequently Asked Questions
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