FISH: BCL6 (3q27) Gene Rearrangement Test
Short Name: BCL6 FISH
Also known as: BCL6 gene rearrangement FISH, 3q27 FISH, BCL6 break-apart FISH
FISH: BCL6 (3q27) Gene Rearrangement Test test available at DNA Labs India for ₹9,000. Uses Fluorescence in situ hybridization (FISH) on Tumor tissue (paraffin-embedded block) samples. Results in Reports are typically available within 7-8 days after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the FISH BCL6 (3q27) gene rearrangement test is to detect chromosomal translocations involving the BCL6 gene. This helps in diagnosing specific types of lymphoma, determining prognosis, and guiding treatment decisions. The test is particularly useful in distinguishing between different subtypes of DLBCL and follicular lymphoma, as BCL6 rearrangement is associated with more aggressive disease and may influence therapy choices.
- Test Code
- 6042
- CPT Code
- 88271, 88275
- ICD Code
- C83.3, C82.9
- Price
- ₹9,000
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Reports are typically available within 7-8 days after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Fluorescence in situ hybridization (FISH)
Sample Collection
No special preparation is required. A doctor's prescription is mandatory. Inform your doctor about any medications you are taking.
Method: Biopsy or surgical resection
Laboratory Analysis
The sample is collected via biopsy procedure by a qualified healthcare professional. The procedure may cause minor discomfort.
Report Delivery
No specific aftercare is required. You can resume normal activities immediately after sample collection.
Timeline: Reports are typically available within 7-8 days after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the FISH BCL6 (3q27) gene rearrangement test is to detect chromosomal translocations involving the BCL6 gene. This helps in diagnosing specific types of lymphoma, determining prognosis, and guiding treatment decisions. The test is particularly useful in distinguishing between different subtypes of DLBCL and follicular lymphoma, as BCL6 rearrangement is associated with more aggressive disease and may influence therapy choices.
How to Prepare
- Tissue sample must be fixed in formalin and embedded in paraffin
- Provide a minimum of 5 unstained sections (4-5 microns thick) on charged slides
- Include a copy of the pathology report if available
- Ensure the sample is properly labeled with patient identification
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"BCL6 rearrangement is a key prognostic marker in diffuse large B-cell lymphoma. FISH testing helps guide targeted therapy and risk stratification."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate tissue sample (less than 20% tumor cells)
- Severely necrotic or autolyzed tissue
- Improperly fixed or decalcified samples
- Unlabeled or mislabeled samples
Understanding Your Results
Negative
No BCL6 rearrangement detected. This suggests a lower likelihood of BCL6-associated lymphoma, but other genetic abnormalities may still be present.
Positive
BCL6 rearrangement detected. This is associated with aggressive lymphomas such as DLBCL and may influence treatment decisions. Further testing may be recommended.
Consult your oncologist or hematologist if you experience persistent symptoms such as enlarged lymph nodes, unexplained fever, night sweats, weight loss, or fatigue. Early diagnosis and treatment can significantly improve outcomes.
Limitations
- ⚠FISH only detects specific rearrangements; other genetic abnormalities may be missed
- ⚠Requires adequate tumor tissue; small biopsies may be insufficient
- ⚠Results should be interpreted in conjunction with histopathology and clinical findings
- ⚠Not a standalone diagnostic test for lymphoma
Risks & Considerations
- ●Minor bleeding or infection at the biopsy site
- ●Discomfort during the biopsy procedure
- ●Rare risk of tissue damage
Interfering Factors
- ●Poor tissue quality or necrosis
- ●Insufficient tumor cells in the sample
- ●Decalcification of bone marrow samples
- ●Fixation artifacts
Compare With Similar Tests
| Test | FISH: BCL6 (3q27) Gene Rearrangement | FISH MYC (8q24) Gene Rearrangement | FISH BCL2 (18q21) Gene Rearrangement | FISH IGH (14q32) Gene Rearrangement |
|---|---|---|---|---|
| Comparison | FISH: BCL6 (3q27) Gene Rearrangement |
Frequently Asked Questions
What is the cost of the FISH BCL6 (3q27) gene rearrangement test at DNA Labs India?
What sample is required for the FISH BCL6 test?
How long does it take to get the results?
Is fasting required before the test?
What is the purpose of the BCL6 FISH test?
Is a doctor's prescription necessary?
Can home sample collection be arranged?
What does a positive BCL6 rearrangement result mean?
Are there any risks associated with the biopsy?
Is the test covered by insurance?
Can the test be done on a blood sample?
What is the turnaround time for reports?
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