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DNA Labs India

Centromere Antibody Test

DNA Labs India | ISO 9001:2015 Certified

Centromere Antibody Test

Also known as: Anti-Centromere Antibody Test, ACA Test

Centromere Antibody Test test available at DNA Labs India for ₹1,580. Uses Enzyme Immunoassay on Serum samples. Results in Sample accepted Tuesday and Friday by 9 am; report delivered the same day.. Free home collection in 300+ cities across India.

Blood TestAdults🏠 Home Collection

🩺 Medically Reviewed By

Overview

The purpose of the Centromere Antibody Test is to aid in the diagnosis of autoimmune diseases, particularly those associated with anti-centromere antibodies, such as scleroderma and CREST syndrome. It helps clinicians confirm the presence of these antibodies, guide treatment plans, and monitor disease progression, contributing to improved patient outcomes through early intervention.

Test Code
280
Price
₹1,580
Sample Type
Serum
Result Time
Sample accepted Tuesday and Friday by 9 am; report delivered the same day.
Fasting Required
Yes (8 hours)
Method
Enzyme Immunoassay
Step 1

Sample Collection

Overnight fasting is preferred. Inform your doctor about any medications or supplements you are taking.

Method: Venipuncture

Step 2

Laboratory Analysis

A healthcare professional will collect a blood sample from a vein in your arm using standard venipuncture procedures.

Step 3

Report Delivery

Apply pressure to the puncture site with a cotton ball or bandage to stop bleeding. You can resume normal activities immediately.

Timeline: Sample accepted Tuesday and Friday by 9 am; report delivered the same day.

Patient Instructions

1
Before the Test:Fast overnight for 8-12 hours if advised. Avoid alcohol and certain medications as per your doctor's instructions.
2
During the Test:A blood sample will be drawn from a vein in your arm. The procedure is quick and typically causes minimal discomfort.
3
After the Test:Results are usually available the same day. Discuss the results with your doctor for interpretation and next steps.

About This Test

Who Should Get This Test

The purpose of the Centromere Antibody Test is to aid in the diagnosis of autoimmune diseases, particularly those associated with anti-centromere antibodies, such as scleroderma and CREST syndrome. It helps clinicians confirm the presence of these antibodies, guide treatment plans, and monitor disease progression, contributing to improved patient outcomes through early intervention.

How to Prepare

  • Overnight fasting (8-12 hours) is preferred for accurate results.
  • Sample: 2 mL (minimum 1 mL) serum from 1 SST (Serum Separator Tube).
  • Ship the sample refrigerated or frozen to maintain stability.
  • Ensure proper labeling and handling to avoid sample rejection.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early detection of centromere antibodies is crucial for managing autoimmune conditions like scleroderma, as it allows for timely intervention and symptom control."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume2 mL (minimum 1 mL)
ContainerSST (Serum Separator Tube)
Collection MethodVenipuncture

Sample Stability

Room Temperature: Not recommended (NA)
Refrigerator (2-8°C): 72 hours
Frozen (-20°C): 2 weeks
Sample Rejection Criteria:
  • Incorrect sample type or container
  • Insufficient sample volume
  • Hemolyzed or lipemic samples
  • Improper storage or delayed transport

Understanding Your Results

The Centromere Antibody Test results help in diagnosing autoimmune diseases. Interpretation should be done by a qualified healthcare professional in conjunction with clinical findings.
Positive Result: Indicates the presence of anti-centromere antibodies, which is suggestive of autoimmune conditions like scleroderma or CREST syndrome. Further evaluation is recommended.
Negative Result: No significant levels of centromere antibodies detected. However, clinical correlation is necessary as it does not completely rule out autoimmune diseases.
Equivocal Result: Borderline or indeterminate results may require repeat testing or additional diagnostic tests.
⚠️ When to Consult a Doctor:

Consult a doctor if you experience persistent symptoms such as Raynaud's phenomenon, skin hardening, joint pain, or other signs of autoimmune disorders, regardless of test results.

Limitations

  • Not diagnostic alone; results must be correlated with clinical symptoms and other tests.
  • May yield false positives in some autoimmune conditions.
  • Does not specify the severity or subtype of autoimmune disease.

Risks & Considerations

  • Minor bruising or swelling at the puncture site
  • Slight pain or discomfort during blood draw
  • Rare risk of infection or dizziness

Interfering Factors

  • Hemolyzed samples
  • Lipemic samples
  • Recent blood transfusion
  • Certain medications (e.g., immunosuppressants)

Frequently Asked Questions

What is the Centromere Antibody Test?
The Centromere Antibody Test is a blood test that detects anti-centromere antibodies, which are often associated with autoimmune diseases like scleroderma and CREST syndrome.
Why is the Centromere Antibody Test performed?
This test is performed to help diagnose autoimmune conditions, especially when symptoms such as Raynaud's phenomenon or skin hardening are present, aiding in early treatment.
What symptoms indicate the need for a Centromere Antibody Test?
Symptoms include Raynaud's phenomenon, skin tightening, swelling of fingers/toes, joint pain, shortness of breath, difficulty swallowing, and heartburn.
How is the Centromere Antibody Test conducted?
It is a simple blood test where a sample is drawn from a vein and analyzed using enzyme immunoassay to detect antibodies.
What do positive Centromere Antibody Test results mean?
A positive result suggests the presence of anti-centromere antibodies, which is indicative of autoimmune diseases such as scleroderma. Further evaluation by a doctor is recommended.
Is fasting required before the Centromere Antibody Test?
Yes, overnight fasting (8-12 hours) is preferred for accurate results, but follow your doctor's specific instructions.
What is the cost of the Centromere Antibody Test?
The cost at DNA Labs India is INR 1579.5, which includes home sample collection and report delivery.
Where can I get the Centromere Antibody Test done?
DNA Labs India offers this test across India with free home collection in numerous cities, including Mumbai, Delhi, Bangalore, and more.
How long does it take to get the Centromere Antibody Test results?
Results are typically available the same day after sample collection, with reports delivered via online portal, email, or WhatsApp.
Are there any risks associated with the Centromere Antibody Test?
Risks are minimal and may include minor bruising at the puncture site or slight discomfort during blood draw. Serious complications are rare.
What other tests might be ordered along with the Centromere Antibody Test?
Other tests such as ANA test, Scl-70 antibody test, or imaging studies like X-rays or MRIs may be ordered to confirm diagnosis.
Can the Centromere Antibody Test definitively diagnose scleroderma?
No, the test helps in diagnosis but is not definitive alone. Clinical correlation with symptoms and other tests is necessary for a confirmed diagnosis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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