Chromosome Analysis Products of Conception Reflex Testing to FISH for Aneuploidy Detection Test
Short Name: POC Reflex FISH Aneuploidy Detection
Also known as: POC Reflex Test, FISH Aneuploidy Detection, Chromosomal Analysis for Miscarriage Tissue
Chromosome Analysis Products of Conception Reflex Testing to FISH for Aneuploidy Detection Test test available at DNA Labs India for ₹8,500. Uses Culture, Microscopy, Karyotype, FISH on Curretted tissue in normal saline samples. Results in Reports available in 4-5 weeks from specimen receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect aneuploidy in products of conception to determine the genetic cause of miscarriage or pregnancy loss, aiding in diagnosis, genetic counseling, and management of future pregnancies.
- Test Code
- 306
- Price
- ₹8,500
- Sample Type
- Curretted tissue in normal saline
- Result Time
- Reports available in 4-5 weeks from specimen receipt.
- Fasting Required
- No
- Method
- Culture, Microscopy, Karyotype, FISH
Sample Collection
Ensure a duly filled Chromosome & FISH Analysis Requisition form (Form 17) is prepared. No fasting required. Inform the healthcare provider about any medications or medical history.
Method: Surgical collection by healthcare professional
Laboratory Analysis
Tissue collected via curettage by a healthcare professional. Specimen placed immediately in normal saline in a sterile container.
Report Delivery
Ship specimen immediately at 18-22°C. Specimen must reach the laboratory within 24 hours. Avoid freezing or using formalin.
Timeline: Reports available in 4-5 weeks from specimen receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect aneuploidy in products of conception to determine the genetic cause of miscarriage or pregnancy loss, aiding in diagnosis, genetic counseling, and management of future pregnancies.
How to Prepare
- Submit curretted tissue in normal saline
- Fetus not accepted
- Ship immediately at 18-22°C
- Specimens must reach LPL, New Delhi within 24 hours
- Formalin fixed specimen not acceptable
- Duly filled Chromosome & FISH Analysis Requisition form (Form 17) is mandatory
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"POC reflex testing with FISH is crucial for identifying chromosomal causes of recurrent miscarriage, aiding in genetic counseling and future pregnancy planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Formalin-fixed specimen
- Specimen not in normal saline
- Delayed transport beyond 24 hours
- Missing or incomplete requisition form
- Contaminated or insufficient tissue
Understanding Your Results
Normal karyotype (46, XX or 46, XY)
No chromosomal abnormalities detected; miscarriage may be due to other factors.
Aneuploidy detected (e.g., trisomy 21)
Genetic abnormality identified as likely cause of pregnancy loss; genetic counseling recommended.
Mosaicism present
Mixed cell population with normal and abnormal chromosomes; clinical significance varies.
Inconclusive or culture failure
Test unable to provide results; consider repeat testing or alternative methods.
Consult a doctor or genetic counselor if results show aneuploidy, recurrent miscarriage occurs, or for guidance on future pregnancy planning and management.
Limitations
- ⚠May not detect all genetic disorders, such as single-gene mutations
- ⚠Limited to aneuploidy detection for specific chromosomes via FISH
- ⚠Cannot identify balanced translocations or small copy number variants
- ⚠Results may be inconclusive if cell culture fails
Risks & Considerations
- ●No direct risks to the patient from the test itself
- ●Risks associated with sample collection procedure (e.g., infection, bleeding) are minimal and managed by healthcare provider
- ●Emotional impact of results; counseling support available
Interfering Factors
- ●Contaminated or improperly stored specimen
- ●Use of formalin-fixed tissue (not acceptable)
- ●Delayed specimen transport beyond 24 hours
- ●Insufficient tissue volume
Compare With Similar Tests
| Test | Chromosome Analysis Products of Conception Reflex Testing to FISH for Aneuploidy Detection Test | Non-Invasive Prenatal Testing (NIPT) | Amniocentesis | Chorionic Villus Sampling (CVS) | Standard Karyotyping |
|---|---|---|---|---|---|
| Comparison | Chromosome Analysis Products of Conception Reflex Testing to FISH for Aneuploidy Detection Test | NIPT screens for aneuploidy using maternal blood; POC testing analyzes fetal tissue post-loss for definitive diagnosis. | Amniocentesis tests amniotic fluid during pregnancy; POC testing is for after pregnancy loss. | CVS samples placental tissue early in pregnancy; POC testing examines expelled tissue post-miscarriage. | Both use chromosome analysis, but POC reflex adds FISH for targeted aneuploidy detection. |
Frequently Asked Questions
What is POC reflex testing?
Why is FISH used in this test?
What sample is required for this test?
Is fasting needed before the test?
How long does it take to get results?
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Can this test detect all genetic disorders?
What if the sample is formalin-fixed?
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