FISH - Amnio Three Probes: Trisomy 18 X & Y Test
Short Name: FISH Trisomy 18 XY Test
Also known as: FISH for Trisomy 18, FISH X & Y Probes Test
FISH - Amnio Three Probes: Trisomy 18 X & Y Test test available at DNA Labs India for ₹10,500. Uses FISH, Fluorescence In Situ Hybridization on Amniotic fluid samples. Results in Reports are ready within 4 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to provide rapid prenatal diagnosis for trisomy 18 and sex chromosome abnormalities, such as monosomy X, to guide clinical management and informed decision-making during pregnancy.
- Test Code
- 569
- Price
- ₹10,500
- Sample Type
- Amniotic fluid
- Result Time
- Reports are ready within 4 days after sample collection.
- Fasting Required
- No
- Method
- FISH, Fluorescence In Situ Hybridization
Sample Collection
Patient must be after 15 weeks gestation. Duly filled Prenatal Genetic Testing Consent Form (Form 18) and Chromosome & FISH Analysis Requisition Form (Form 17) are mandatory. Discuss risks and benefits with the healthcare provider.
Method: Amniocentesis
Laboratory Analysis
Amniocentesis is performed under ultrasound guidance. A thin needle is inserted through the abdomen to withdraw 10-20 mL of amniotic fluid. The procedure takes about 10-15 minutes.
Report Delivery
Monitor for signs of infection, leakage, or contractions. Avoid strenuous activity for 24 hours. Report any symptoms like fever, severe pain, or fluid leakage to the doctor immediately.
Timeline: Reports are ready within 4 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to provide rapid prenatal diagnosis for trisomy 18 and sex chromosome abnormalities, such as monosomy X, to guide clinical management and informed decision-making during pregnancy.
How to Prepare
- Sample must be taken after 15 weeks gestation
- Collect 10 mL (7 mL min.) of amniotic fluid in a sterile screw capped container
- Ship at 18-22°C; do not freeze
- Complete mandatory forms: Prenatal Genetic Testing Consent Form (Form 18) and Chromosome & FISH Analysis Requisition Form (Form 17)
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This FISH test provides rapid and accurate prenatal diagnosis for trisomy 18 and sex chromosome issues, aiding in early decision-making for high-risk pregnancies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample frozen
- Inadequate volume
- Non-sterile container
- Missing consent or requisition forms
- Sample collected before 15 weeks gestation
Understanding Your Results
Normal: Two copies of chromosome 18, normal sex chromosomes
No aneuploidy detected for targeted chromosomes
Trisomy 18 Detected
Three copies of chromosome 18; consistent with Edwards syndrome
Sex Chromosome Abnormality Detected
Abnormalities such as monosomy X (Turner syndrome) or extra X/Y chromosomes
Inconclusive
Insufficient cells or technical issues; repeat testing may be needed
Consult a doctor if results are abnormal, if you experience complications after amniocentesis, or for genetic counseling to understand implications and options.
Limitations
- ⚠Only detects targeted abnormalities (trisomy 18 and sex chromosomes)
- ⚠Not a substitute for full chromosome karyotype analysis
- ⚠May not detect mosaicism or structural abnormalities
- ⚠Requires invasive procedure with associated risks
Risks & Considerations
- ●Risk of miscarriage (approximately 0.1-0.3%)
- ●Infection at puncture site
- ●Leakage of amniotic fluid
- ●Mild cramping or spotting
- ●Needle injury to fetus (rare)
Interfering Factors
- ●Contaminated or inadequate sample
- ●Improper sample storage (e.g., frozen)
- ●Maternal cell contamination
- ●Low fetal cell count
Compare With Similar Tests
| Test | FISH - Amnio Three Probes: Trisomy 18 X & Y Test | Chorionic Villus Sampling (CVS) | Non-Invasive Prenatal Testing (NIPT) | Amniocentesis Karyotype | FISH for Other Chromosomes |
|---|---|---|---|---|---|
| Comparison | FISH - Amnio Three Probes: Trisomy 18 X & Y Test |
Frequently Asked Questions
What is the FISH - Amnio Three Probes: Trisomy 18 X & Y Test?
When is this test recommended?
How is the sample collected?
What is the cost of the test?
How long does it take to get results?
Are there any risks associated with the test?
Is home sample collection available?
What does a positive result mean?
Can this test detect all chromosomal issues?
Do I need to fast before the test?
What documents are required for the test?
Is the test covered by insurance?
Related Tests
Chromosome Analysis Cord Blood Test
₹4,000Chromosome Analysis Products of Conception Reflex Testing to FISH for Aneuploidy Detection Test
₹8,500Chromotouch Chromosome SNP Microarray Optima Products of Conception Test
₹18,500FISH - Amnio Two Probes: Trisomy 13 & 21 Test
₹7,500FISH - SRY Gene Test
₹7,371FISH - Trisomy 21 / Down Syndrome Test
₹6,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.