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FISH - Amnio Two Probes: Trisomy 13 & 21 Test

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FISH - Amnio Two Probes: Trisomy 13 & 21 Test

Short Name: FISH Amnio Trisomy 13 & 21

Also known as: Prenatal FISH Test for Trisomies 13 & 21, FISH for Down Syndrome and Patau Syndrome

FISH - Amnio Two Probes: Trisomy 13 & 21 Test test available at DNA Labs India for ₹7,500. Uses FISH (Fluorescence In Situ Hybridization) on Amniotic fluid samples. Results in Reports are available within 4 days via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.

DiagnosticFemaleFetal🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To be used as a prenatal screen, in conjunction with full chromosome analysis, to detect aneuploidy such as trisomies 13 and 21, and other conditions like monosomy X.

Test Code
573
Price
₹7,500
Sample Type
Amniotic fluid
Result Time
Reports are available within 4 days via online portal, email, or WhatsApp.
Fasting Required
No
Method
FISH (Fluorescence In Situ Hybridization)
Step 1

Sample Collection

Ensure prenatal genetic testing consent form (Form 18) and chromosome & FISH analysis requisition form (Form 17) are duly filled. Schedule procedure after 15 weeks gestation.

Method: Amniocentesis

Step 2

Laboratory Analysis

Amniocentesis is performed by a qualified healthcare provider under ultrasound guidance to collect amniotic fluid.

Step 3

Report Delivery

Monitor for any signs of complications such as bleeding or cramping. Rest as advised and follow up with your healthcare provider.

Timeline: Reports are available within 4 days via online portal, email, or WhatsApp.

Patient Instructions

1
Before the Test:Complete necessary forms and ensure gestation age is over 15 weeks. Discuss risks and benefits with your doctor.
2
During the Test:Ultrasound-guided amniocentesis procedure takes about 15-30 minutes.
3
After the Test:Rest for a day, avoid strenuous activities, and monitor for any adverse symptoms.

About This Test

Who Should Get This Test

To be used as a prenatal screen, in conjunction with full chromosome analysis, to detect aneuploidy such as trisomies 13 and 21, and other conditions like monosomy X.

How to Prepare

  • Sample must be taken after 15 weeks gestation
  • 10 mL of amniotic fluid collected in a sterile screw capped container
  • Ship at room temperature (18-22°C); do not freeze
  • Duly filled consent and requisition forms are mandatory

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is crucial for early detection of chromosomal abnormalities in high-risk pregnancies, enabling informed decisions and appropriate care planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeAmniotic fluid
Sample Volume10 mL (7 mL min.)
ContainerSterile screw capped container
Collection MethodAmniocentesis

Sample Stability

Room Temperature: 48 hours
Refrigerator: Not applicable
Frozen: Not applicable
Sample Rejection Criteria:
  • Insufficient sample volume (<7 mL)
  • Contaminated or improperly sealed container
  • Missing or incomplete consent/requisition forms
  • Sample received after 48 hours at room temperature

Understanding Your Results

Results indicate the presence or absence of trisomy 13 and 21 signals in the fetal cells from amniotic fluid.
Positive: 3 signals for a probe indicates trisomy (e.g., trisomy 13 or 21)
Negative: 2 signals for both probes indicates normal disomy
Inconclusive: May require repeat testing or full karyotype analysis
⚠️ When to Consult a Doctor:

If results are abnormal, or if you experience any symptoms or concerns during pregnancy, consult your healthcare provider immediately.

Limitations

  • ⚠Detects only trisomy 13 and 21; does not screen for other chromosomal abnormalities
  • ⚠Not a substitute for full karyotype analysis
  • ⚠Results may be inconclusive in rare cases

Risks & Considerations

  • ●Small risk of miscarriage (about 0.1-0.3%)
  • ●Possible infection or bleeding
  • ●Leakage of amniotic fluid

Interfering Factors

  • ●Poor sample quality or low cell count
  • ●Contamination of amniotic fluid sample
  • ●Maternal cell contamination

Compare With Similar Tests

TestFISH - Amnio Two Probes: Trisomy 13 & 21 TestNIPT (Non-Invasive Prenatal Testing)Amniocentesis for Full KaryotypeChorionic Villus Sampling (CVS)
ComparisonFISH - Amnio Two Probes: Trisomy 13 & 21 Test

Frequently Asked Questions

What is the FISH Amnio Two Probes test for Trisomy 13 & 21?
It is a prenatal diagnostic test using FISH technology to detect trisomy 13 (Patau syndrome) and trisomy 21 (Down syndrome) in fetal cells from amniotic fluid.
How is the test performed?
Amniocentesis is performed after 15 weeks gestation to collect amniotic fluid, which is then analyzed using FISH probes for specific chromosomes.
When is the test recommended?
Recommended for high-risk pregnancies, such as those with advanced maternal age, family history of genetic disorders, or abnormal ultrasound findings.
What are the risks of amniocentesis?
Risks include a small chance of miscarriage (0.1-0.3%), infection, bleeding, or amniotic fluid leakage.
How accurate is the FISH test?
FISH is highly accurate for detecting targeted trisomies, with sensitivity and specificity often above 99%, but results should be confirmed with full karyotype if needed.
What do the results mean?
Positive results indicate trisomy (three signals for a probe), while negative results show normal disomy (two signals). Inconclusive results may require further testing.
How long does it take to get results?
Results are typically available within 4 days after sample collection.
What is the cost of the test?
The test costs INR 7500 at DNA Labs India, which includes the testing procedure and genetic counseling.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across numerous cities in India.
Do I need to fast before the test?
No, fasting is not required. The test is scheduled based on gestation age, not dietary restrictions.
What should I do after the test?
Rest for a day, avoid strenuous activities, and monitor for any symptoms like fever or severe pain. Contact your doctor if concerned.
Can the test detect other genetic abnormalities?
No, this test specifically targets trisomy 13 and 21. For comprehensive screening, a full karyotype or other tests may be recommended.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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