CLL NGS Panel (FISH +KT + IGVH Mutation Analysis+ NGS TP53 Mutation Analysis) Test
Short Name: CLL NGS Panel
Also known as: CLL Comprehensive Panel, CLL Mutation Panel, CLL FISH + IGVH + TP53 NGS
CLL NGS Panel (FISH +KT + IGVH Mutation Analysis+ NGS TP53 Mutation Analysis) Test test available at DNA Labs India for ₹39,000. Uses Cell Culture, FISH, PCR, NGS on Peripheral blood + FFPE block samples. Results in Reports are available within 3 weeks from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the CLL NGS Panel is to provide a comprehensive molecular and cytogenetic profile of Chronic Lymphocytic Leukemia to aid in diagnosis, prognosis, and therapeutic decision-making. It helps identify high-risk genetic aberrations such as TP53 mutations and del(17p) that predict resistance to standard chemotherapy, enabling oncologists to choose targeted therapies like ibrutinib or venetoclax. IGVH mutation status distinguishes between mutated (better prognosis) and unmutated (poorer prognosis) CLL. FISH and karyotyping reveal chromosomal abnormalities that influence disease progression. Overall, this panel supports personalized management of CLL patients.
- Test Code
- 6074
- CPT Code
- 81445
- ICD Code
- C91.1
- Price
- ₹39,000
- Sample Type
- Peripheral blood + FFPE block
- Result Time
- Reports are available within 3 weeks from sample receipt.
- Fasting Required
- No
- Method
- Cell Culture, FISH, PCR, NGS
Sample Collection
No special preparation required. A doctor's prescription is mandatory. Inform the lab about any ongoing medications or recent treatments.
Method: Venipuncture
Laboratory Analysis
Blood sample will be collected by venipuncture. For FFPE block, the tissue block will be obtained from the referring hospital.
Report Delivery
No restrictions. Resume normal activities.
Timeline: Reports are available within 3 weeks from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the CLL NGS Panel is to provide a comprehensive molecular and cytogenetic profile of Chronic Lymphocytic Leukemia to aid in diagnosis, prognosis, and therapeutic decision-making. It helps identify high-risk genetic aberrations such as TP53 mutations and del(17p) that predict resistance to standard chemotherapy, enabling oncologists to choose targeted therapies like ibrutinib or venetoclax. IGVH mutation status distinguishes between mutated (better prognosis) and unmutated (poorer prognosis) CLL. FISH and karyotyping reveal chromosomal abnormalities that influence disease progression. Overall, this panel supports personalized management of CLL patients.
How to Prepare
- Use Sodium Heparin and EDTA vacutainers as specified
- Ensure proper mixing of blood with anticoagulant
- Transport samples at room temperature (cool pack recommended for long transit)
- FFPE block should be shipped in a sealed container
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This comprehensive panel integrates FISH, karyotype, IGVH mutation status, and TP53 NGS to guide prognosis and therapy selection in CLL. Early molecular profiling is critical for risk-adapted management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted blood sample
- Hemolyzed sample
- Incorrect anticoagulant
- Insufficient volume
- Improperly labeled sample
Understanding Your Results
del(17p) or TP53 mutation
High-risk; poor response to chemoimmunotherapy; consider targeted agents (BTK inhibitors, BCL2 inhibitors)
del(11q)
Intermediate-high risk; may benefit from targeted therapy
Trisomy 12
Intermediate risk; variable prognosis
del(13q) as sole abnormality
Good prognosis; standard chemoimmunotherapy may be effective
Unmutated IGVH
Poor prognosis; more aggressive disease
Mutated IGVH
Better prognosis; indolent course
Complex karyotype
High-risk; associated with poorer outcomes
Consult your oncologist if you have been diagnosed with CLL or if you experience symptoms such as persistent fatigue, unexplained weight loss, night sweats, or enlarged lymph nodes. The results of this panel should be discussed with your doctor to plan appropriate treatment.
Limitations
- ⚠FISH only detects targeted abnormalities; other cryptic aberrations may be missed
- ⚠Karyotyping requires viable cells; culture failure may occur
- ⚠IGVH analysis may be inconclusive in cases with low B-cell count
- ⚠NGS TP53 analysis may miss large deletions or deep intronic variants
- ⚠Results should be interpreted in conjunction with clinical and pathological findings
Risks & Considerations
- ●Minimal risk of bruising or bleeding at venipuncture site
- ●Rare risk of infection
- ●No radiation exposure from blood sample
Interfering Factors
- ●Recent chemotherapy or radiation therapy may affect cell viability and karyotyping
- ●Insufficient sample volume or poor sample quality
- ●Clotted blood sample
- ●Delayed processing of sample
- ●Maternal cell contamination in FFPE blocks
Compare With Similar Tests
| Test | CLL NGS Panel (FISH +KT + IGVH Mutation Analysis+ NGS TP53 Mutation Analysis) | CLL FISH Panel | CLL Karyotyping | IGVH Mutation Analysis | TP53 NGS |
|---|---|---|---|---|---|
| Comparison | CLL NGS Panel (FISH +KT + IGVH Mutation Analysis+ NGS TP53 Mutation Analysis) |
Frequently Asked Questions
What is the cost of the CLL NGS Panel?
What sample is required for this test?
Is fasting required before the test?
How long does it take to get the report?
What is the purpose of IGVH mutation analysis?
What does TP53 mutation analysis detect?
Can this test be done without a doctor's prescription?
Is home sample collection available?
What is the significance of FISH in CLL?
What is the turnaround time for the test?
Are there any risks associated with the test?
How should the sample be transported?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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