Comprehensive Tumor Panel 270 Genes+ PDL1 Test
Short Name: CTP 270 + PDL1
Also known as: Tumor Profiling Panel, Cancer Gene Panel 270, PD-L1 Expression Test
Comprehensive Tumor Panel 270 Genes+ PDL1 Test test available at DNA Labs India for ₹49,380. Uses Next-Generation Sequencing (NGS), Immunohistochemistry (IHC) for PDL1 on Tumor tissue biopsy samples. Results in Results are typically available within 4 weeks from the time the sample is received at the lab. You will be notified via email or SMS when the report is ready.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Comprehensive Tumor Panel 270 Genes + PDL1 is to identify actionable genetic alterations in tumor DNA that can guide treatment decisions. It helps in: 1) Detecting mutations in oncogenes and tumor suppressor genes, 2) Assessing PDL1 expression to predict immunotherapy response, 3) Identifying potential targets for FDA-approved targeted therapies, 4) Discovering resistance mechanisms to current treatments, 5) Providing prognostic information, 6) Matching patients to clinical trials, and 7) Informing hereditary cancer risk assessment when germline testing is included.
- Test Code
- 6289
- CPT Code
- 81479
- ICD Code
- C80.1
- Price
- ₹49,380
- Sample Type
- Tumor tissue biopsy
- Result Time
- Results are typically available within 4 weeks from the time the sample is received at the lab. You will be notified via email or SMS when the report is ready.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Immunohistochemistry (IHC) for PDL1
Sample Collection
No special preparation is required. However, inform your doctor about all medications you are taking, especially immunosuppressants or anticoagulants, as they may affect the biopsy procedure.
Method: Biopsy (surgical or core needle)
Laboratory Analysis
The biopsy procedure is performed under local or general anesthesia. A small sample of tumor tissue is removed using a needle or during surgery. You may feel slight discomfort, but it is generally well-tolerated.
Report Delivery
After the biopsy, you may experience mild soreness or bleeding at the site. Follow your doctor's instructions for wound care. Avoid strenuous activities for 24 hours. Contact your doctor if you have excessive bleeding, fever, or signs of infection.
Timeline: Results are typically available within 4 weeks from the time the sample is received at the lab. You will be notified via email or SMS when the report is ready.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Comprehensive Tumor Panel 270 Genes + PDL1 is to identify actionable genetic alterations in tumor DNA that can guide treatment decisions. It helps in: 1) Detecting mutations in oncogenes and tumor suppressor genes, 2) Assessing PDL1 expression to predict immunotherapy response, 3) Identifying potential targets for FDA-approved targeted therapies, 4) Discovering resistance mechanisms to current treatments, 5) Providing prognostic information, 6) Matching patients to clinical trials, and 7) Informing hereditary cancer risk assessment when germline testing is included.
How to Prepare
- Tissue sample must be placed in a sterile container with 10% neutral buffered formalin
- The sample should be sent to the lab within 24 hours of collection
- For FFPE blocks, ensure proper labeling with patient ID and site of biopsy
- Avoid freezing the tissue unless specifically instructed
- Include a pathology report if available
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This panel is essential for identifying actionable mutations and PDL1 status, guiding targeted therapy and immunotherapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample with insufficient tumor cells (<20% tumor content)
- Sample not properly fixed or decalcified
- Sample without proper labeling
- Sample received in inappropriate transport medium
- Hemolyzed or contaminated samples
Understanding Your Results
EGFR mutation (e.g., L858R, exon 19 deletion)
Sensitivity to EGFR tyrosine kinase inhibitors (e.g., erlotinib, osimertinib)
BRAF V600E mutation
Potential benefit from BRAF inhibitors (e.g., vemurafenib, dabrafenib)
PDL1 TPS ≥50%
High likelihood of response to PD-1/PD-L1 inhibitors (e.g., pembrolizumab)
MSI-H
Eligibility for immune checkpoint inhibitors regardless of tumor type
TMB ≥10 mutations/Mb
Higher response rates to immunotherapy
Consult your oncologist immediately if you have been diagnosed with cancer and are considering targeted therapy or immunotherapy. Also, if you have a family history of cancer, discuss the need for genetic counseling and testing.
Limitations
- ⚠This panel does not detect all possible genetic alterations (e.g., large rearrangements may be missed)
- ⚠PDL1 expression can be heterogeneous within a tumor, leading to sampling bias
- ⚠Results are not diagnostic of cancer; they are for treatment guidance
- ⚠Germline mutations are not routinely reported unless specifically requested
- ⚠The test is not a substitute for histopathological diagnosis
Risks & Considerations
- ●Bleeding at the biopsy site
- ●Infection
- ●Pneumothorax (if lung biopsy)
- ●Damage to nearby organs (rare)
- ●Anesthesia-related complications
Interfering Factors
- ●Insufficient tumor content in the biopsy sample
- ●Poor DNA quality due to prolonged formalin fixation
- ●Decalcification of bone samples may degrade DNA
- ●Recent chemotherapy or radiation may affect mutation detection
- ●Low tumor cellularity (<20%) may lead to false negatives
Compare With Similar Tests
| Test | Comprehensive Tumor Panel 270 Genes+ PDL1 | Targeted Gene Panel (50 genes) | Whole Exome Sequencing | PDL1 IHC only |
|---|---|---|---|---|
| Comparison | Comprehensive Tumor Panel 270 Genes+ PDL1 |
Frequently Asked Questions
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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