Comprehensive Tumor Panel (SNVs, Small Indels, Fusions) + TMB + MSI (526 Genes) Test
Short Name: Comprehensive Tumor Panel 526 Genes
Also known as: Tumor Profiling Panel, Cancer Genomic Panel, 526-Gene Tumor Sequencing
Comprehensive Tumor Panel (SNVs, Small Indels, Fusions) + TMB + MSI (526 Genes) Test test available at DNA Labs India for ₹79,000. Uses Next-Generation Sequencing (NGS) on FFPE Tissue Block samples. Results in 4 weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of this test is to identify genetic alterations in tumor cells to guide personalized cancer therapy. It helps in selecting targeted treatments, assessing immunotherapy eligibility based on TMB and MSI status, and providing prognostic information for treatment planning.
- Test Code
- 3440
- Price
- ₹79,000
- Sample Type
- FFPE Tissue Block
- Result Time
- 4 weeks from sample receipt
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Ensure the FFPE tissue block is properly prepared and labeled. Inform the patient about the biopsy procedure if not already done. No specific fasting or preparation is required for the patient.
Method: Biopsy or Surgical Resection
Laboratory Analysis
The tissue sample is collected via biopsy or surgical resection by a qualified healthcare professional. The sample is then fixed in formalin and embedded in paraffin to create an FFPE block.
Report Delivery
The FFPE block is stored at room temperature and transported to the lab under stable conditions. Patients can resume normal activities post-biopsy as per medical advice.
Timeline: 4 weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of this test is to identify genetic alterations in tumor cells to guide personalized cancer therapy. It helps in selecting targeted treatments, assessing immunotherapy eligibility based on TMB and MSI status, and providing prognostic information for treatment planning.
How to Prepare
- Obtain informed consent from the patient
- Collect adequate tumor tissue during biopsy or surgery
- Fix tissue in 10% neutral buffered formalin for 6-48 hours
- Embed in paraffin and prepare FFPE block
- Label the block with patient details and test requisition
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This comprehensive panel is crucial for personalizing cancer treatment by identifying specific genetic mutations, tumor mutation burden, and microsatellite instability status, which guide targeted therapy and immunotherapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor tissue (<20% cellularity)
- Degraded or necrotic tissue
- Improperly labeled or contaminated samples
- Non-FFPE samples (e.g., fresh frozen without prior agreement)
Understanding Your Results
May indicate eligibility for specific targeted therapies
Associated with better response to immune checkpoint inhibitors
Suggests potential benefit from immunotherapy, regardless of cancer type
Consider standard treatments or clinical trials; retesting may be advised if disease progresses
Consult your oncologist immediately after receiving the test results to discuss personalized treatment options, potential side effects, and next steps in your cancer care plan.
Limitations
- ⚠May not detect all types of genetic alterations, such as large rearrangements or copy number variations
- ⚠Results are dependent on tumor heterogeneity and sample quality
- ⚠Not validated for liquid biopsy or blood samples
- ⚠Interpretation requires correlation with clinical and pathological data
Risks & Considerations
- ●Minimal risks associated with biopsy procedure (e.g., bleeding, infection)
- ●No direct risks from the genetic test itself, as it is performed on already collected tissue
Interfering Factors
- ●Low tumor cell content in the sample (<20%)
- ●Degraded or insufficient DNA from FFPE tissue
- ●Contamination during sample processing
- ●Use of fixatives other than formalin
Compare With Similar Tests
| Test | Comprehensive Tumor Panel (SNVs, Small Indels, Fusions) + TMB + MSI (526 Genes) | BRCA1/2 Mutation Test | PD-L1 Immunohistochemistry | Single-Gene PCR Tests | Whole Exome Sequencing |
|---|---|---|---|---|---|
| Comparison | Comprehensive Tumor Panel (SNVs, Small Indels, Fusions) + TMB + MSI (526 Genes) | Focuses on specific genes for hereditary breast/ovarian cancer, while this panel covers 526 genes for broader profiling | Assesses protein expression for immunotherapy eligibility, whereas this panel includes TMB and MSI for comprehensive biomarker analysis | Detects one mutation at a time; this NGS panel analyzes multiple genes simultaneously for efficiency | Covers all coding genes but may have higher cost and longer turnaround; this panel is targeted for cancer-relevant genes |
Frequently Asked Questions
What is the Comprehensive Tumor Panel (SNVs, Small Indels, Fusions) + TMB + MSI (526 Genes)?
Who should consider taking this test?
How is the sample collected for this test?
What is the turnaround time for results?
What does TMB stand for and why is it important?
What is MSI and how does it affect treatment?
How can this test help in my cancer treatment?
Is the test covered by insurance?
What are the risks associated with this test?
How accurate is the Comprehensive Tumor Panel?
Can this test be done on blood samples instead of tissue?
What should I do after receiving the test results?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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