Del[11q(ATM)] (MM, CLL) Test
Short Name: Del(11q) FISH
Also known as: Del(11q) FISH, ATM gene deletion test, 11q deletion analysis
Del[11q(ATM)] (MM, CLL) Test test available at DNA Labs India for ₹5,250. Uses Fluorescence In Situ Hybridization (FISH) on Bone Marrow / Peripheral blood samples. Results in Results are typically available within 3-4 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the Del[11q(ATM)] test is to detect the deletion of the ATM gene region on chromosome 11 in patients with multiple myeloma (MM) or chronic lymphocytic leukemia (CLL). This genetic abnormality is associated with poor prognosis and aggressive disease behavior. The test aids in risk stratification, helping oncologists determine the likely course of the disease and select appropriate treatment protocols. For example, in CLL, patients with 11q deletion may benefit from chemoimmunotherapy regimens or novel agents like ibrutinib. In MM, the presence of 11q deletion may influence the choice of induction therapy and maintenance strategies. Additionally, the test is used for monitoring minimal residual disease and detecting clonal evolution during the course of the disease. By identifying this genetic marker, clinicians can provide more personalized and targeted care, potentially improving patient outcomes.
- Test Code
- 6082
- CPT Code
- 88271, 88275
- ICD Code
- C90.0, C91.1
- Price
- ₹5,250
- Sample Type
- Bone Marrow / Peripheral blood
- Result Time
- Results are typically available within 3-4 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation is required. However, a doctor's prescription is mandatory. Inform your physician about any medications you are taking, especially anticoagulants or chemotherapy agents.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
A blood sample will be drawn from a vein in your arm, or a bone marrow aspirate may be collected from the hip bone. The procedure is quick and may cause minor discomfort.
Report Delivery
You can resume normal activities immediately. If a bone marrow biopsy was performed, you may experience soreness at the site, which should resolve within a few days. Apply ice if needed and avoid strenuous activity for 24 hours.
Timeline: Results are typically available within 3-4 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Del[11q(ATM)] test is to detect the deletion of the ATM gene region on chromosome 11 in patients with multiple myeloma (MM) or chronic lymphocytic leukemia (CLL). This genetic abnormality is associated with poor prognosis and aggressive disease behavior. The test aids in risk stratification, helping oncologists determine the likely course of the disease and select appropriate treatment protocols. For example, in CLL, patients with 11q deletion may benefit from chemoimmunotherapy regimens or novel agents like ibrutinib. In MM, the presence of 11q deletion may influence the choice of induction therapy and maintenance strategies. Additionally, the test is used for monitoring minimal residual disease and detecting clonal evolution during the course of the disease. By identifying this genetic marker, clinicians can provide more personalized and targeted care, potentially improving patient outcomes.
How to Prepare
- Use Sodium Heparin Vacutainer (2 ml) for blood sample
- For bone marrow, use appropriate anticoagulant as per lab protocol
- Label the sample with patient name, date, and time of collection
- Transport the sample to the laboratory at ambient temperature (15-25°C)
- Do not freeze the sample
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The 11q deletion is a high-risk cytogenetic abnormality in CLL and MM. Early detection via FISH helps in risk stratification and treatment planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed sample
- Incorrect anticoagulant used
- Sample received after 48 hours of collection
- Unlabeled or mislabeled sample
- Insufficient sample volume
Understanding Your Results
Negative
No deletion of the ATM gene region detected. Standard risk stratification applies.
Positive (low percentage)
Deletion present in a small fraction of cells. May indicate early clonal evolution or minimal residual disease. Close monitoring recommended.
Positive (high percentage)
Deletion present in a significant proportion of cells. High-risk disease. Aggressive treatment and targeted therapy may be considered.
Consult your oncologist if you have been diagnosed with CLL or MM and have not undergone cytogenetic testing. Also, if you experience new or worsening symptoms such as unexplained weight loss, night sweats, persistent fatigue, or bone pain, discuss the need for this test with your doctor.
Limitations
- ⚠FISH only detects specific known deletions; other mutations may not be identified
- ⚠Results may be affected by low tumor burden or sample quality
- ⚠Test does not provide information on gene expression or protein function
- ⚠Clinical correlation with other laboratory and imaging findings is essential
Risks & Considerations
- ●Minor bleeding or bruising at the puncture site
- ●Infection (rare, if proper sterile technique is not followed)
- ●Discomfort during bone marrow aspiration
Interfering Factors
- ●Inadequate sample volume or poor quality DNA
- ●Hemolysis or clotting of blood sample
- ●Recent blood transfusion (may dilute abnormal cells)
- ●Bone marrow fibrosis or hemodilution
- ●Prior chemotherapy or radiation therapy may affect results
Compare With Similar Tests
| Test | Del[11q(ATM)] (MM, CLL) | Del(17p) FISH | Trisomy 12 FISH | IgH Translocation Panel |
|---|---|---|---|---|
| Comparison | Del[11q(ATM)] (MM, CLL) | Del(17p) is another high-risk marker in CLL/MM, associated with TP53 loss. Both tests are often performed together for comprehensive risk assessment. | Trisomy 12 is a favorable prognostic marker in CLL, unlike Del(11q) which is unfavorable. Combined testing helps in risk stratification. | This panel detects translocations involving the immunoglobulin heavy chain gene, common in MM. It complements Del(11q) testing. |
Frequently Asked Questions
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