Del[13q] (MM, CLL) Test
Short Name: Del[13q]
Also known as: 13q deletion, Del(13q) FISH, 13q14 deletion
Del[13q] (MM, CLL) Test test available at DNA Labs India for ₹5,250. Uses Fluorescence In Situ Hybridization (FISH) on Bone Marrow / Peripheral Blood samples. Results in Reports are typically available within 3-4 days after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Del[13q] (MM, CLL) test is to detect the deletion of chromosome 13q14 region, which is a key genetic marker in Multiple Myeloma and Chronic Lymphocytic Leukemia. This test aids in diagnosis, prognosis, risk stratification, and monitoring of these hematological malignancies. It helps oncologists determine the appropriate treatment strategy and predict patient outcomes.
- Test Code
- 6083
- CPT Code
- 88271, 88275
- ICD Code
- C90.0, C91.1
- Price
- ₹5,250
- Sample Type
- Bone Marrow / Peripheral Blood
- Result Time
- Reports are typically available within 3-4 days after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation is required. A doctor's prescription is mandatory. Inform your physician about any medications you are taking.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
A blood sample will be drawn from a vein in your arm, or a bone marrow biopsy will be performed by a healthcare professional. The procedure is quick and generally well-tolerated.
Report Delivery
You may resume normal activities immediately. If a bone marrow biopsy was performed, you may experience mild soreness at the site, which should resolve within a few days.
Timeline: Reports are typically available within 3-4 days after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Del[13q] (MM, CLL) test is to detect the deletion of chromosome 13q14 region, which is a key genetic marker in Multiple Myeloma and Chronic Lymphocytic Leukemia. This test aids in diagnosis, prognosis, risk stratification, and monitoring of these hematological malignancies. It helps oncologists determine the appropriate treatment strategy and predict patient outcomes.
How to Prepare
- Use Sodium Heparin Vacutainer (2 ml) for peripheral blood
- For bone marrow, collect in a heparinized syringe
- Label the sample with patient name, date, and time of collection
- Transport the sample to the laboratory at ambient temperature (15-25°C)
- Do not refrigerate or freeze the sample
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Del[13q] is a common cytogenetic abnormality in MM and CLL. Its detection aids in risk stratification and treatment planning. Early identification can guide targeted therapy and improve patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Hemolyzed sample
- Incorrect container
- Sample received after 24 hours
- Unlabeled or mislabeled sample
Understanding Your Results
No deletion of chromosome 13q detected. This is considered a normal result.
Deletion detected. In Multiple Myeloma, del(13q) is associated with a poorer prognosis and may influence treatment choices.
Deletion detected. In CLL, isolated del(13q) is generally associated with a favorable prognosis, but the presence of additional abnormalities may alter the outlook.
Consult your oncologist or hematologist if you have been diagnosed with MM or CLL and have not undergone genetic testing. Also, seek medical advice if you experience new or worsening symptoms such as bone pain, fatigue, recurrent infections, or unexplained weight loss.
Limitations
- ⚠FISH only detects specific deletions; other cytogenetic abnormalities may not be identified
- ⚠Results should be interpreted in conjunction with clinical findings and other tests
- ⚠Low-level mosaicism may be missed
- ⚠Bone marrow sample may not be representative if patchy involvement
Risks & Considerations
- ●Minimal risk of bleeding or infection at the blood draw site
- ●Bone marrow biopsy may cause temporary pain or bruising
- ●Rare risk of nerve damage during bone marrow aspiration
Interfering Factors
- ●Recent blood transfusion may dilute abnormal cells
- ●Inadequate sample volume or clotting
- ●Delayed processing of sample
- ●Prior chemotherapy may affect cell viability
Compare With Similar Tests
| Test | Del[13q] (MM, CLL) | FISH Panel for CLL | Cytogenetic Analysis (Karyotype) | Next-Generation Sequencing (NGS) |
|---|---|---|---|---|
| Comparison | Del[13q] (MM, CLL) | Del[13q] FISH is often part of a larger FISH panel that includes probes for 11q, 17p, and 12 trisomy. This panel provides a comprehensive risk assessment in CLL. | Karyotyping detects large chromosomal abnormalities but may miss small deletions like del(13q). FISH is more sensitive for specific deletions. | NGS can detect gene mutations and copy number variations, but FISH is faster and more cost-effective for targeted deletion detection. |
Frequently Asked Questions
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