Del[17p(p53)] (MM, CLL) Test
Short Name: Del17p FISH
Also known as: 17p deletion, p53 deletion, Del(17p)
Del[17p(p53)] (MM, CLL) Test test available at DNA Labs India for ₹5,250. Uses Fluorescence In Situ Hybridization (FISH) on Bone Marrow / Peripheral Blood samples. Results in Results are typically available within 3-4 business days after the sample reaches the laboratory. You will be notified via email or WhatsApp when the report is ready.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Del[17p(p53)] test is to detect the deletion of the TP53 gene on chromosome 17, which is a critical prognostic and predictive biomarker in multiple myeloma and chronic lymphocytic leukemia. This test helps clinicians assess disease aggressiveness, guide treatment decisions, and monitor disease progression. In MM, Del(17p) is associated with high-risk cytogenetics, leading to shorter progression-free survival and overall survival. In CLL, Del(17p) predicts resistance to standard chemoimmunotherapy and indicates the need for targeted agents. The test is also used to evaluate minimal residual disease and to identify patients who may benefit from clinical trials or stem cell transplantation. Early detection of Del(17p) enables personalized treatment strategies, improving patient outcomes.
- Test Code
- 6085
- CPT Code
- 88271
- ICD Code
- D47.2
- Price
- ₹5,250
- Sample Type
- Bone Marrow / Peripheral Blood
- Result Time
- Results are typically available within 3-4 business days after the sample reaches the laboratory. You will be notified via email or WhatsApp when the report is ready.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation is required. A doctor's prescription is mandatory. Inform your physician about any ongoing medications or treatments.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
The sample is collected by a trained phlebotomist or oncologist. For bone marrow aspiration, a local anesthetic is applied. For peripheral blood, a standard venipuncture is performed.
Report Delivery
No specific aftercare is needed. You may resume normal activities immediately. The sample is transported to the laboratory under controlled conditions.
Timeline: Results are typically available within 3-4 business days after the sample reaches the laboratory. You will be notified via email or WhatsApp when the report is ready.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Del[17p(p53)] test is to detect the deletion of the TP53 gene on chromosome 17, which is a critical prognostic and predictive biomarker in multiple myeloma and chronic lymphocytic leukemia. This test helps clinicians assess disease aggressiveness, guide treatment decisions, and monitor disease progression. In MM, Del(17p) is associated with high-risk cytogenetics, leading to shorter progression-free survival and overall survival. In CLL, Del(17p) predicts resistance to standard chemoimmunotherapy and indicates the need for targeted agents. The test is also used to evaluate minimal residual disease and to identify patients who may benefit from clinical trials or stem cell transplantation. Early detection of Del(17p) enables personalized treatment strategies, improving patient outcomes.
How to Prepare
- Use Sodium Heparin Vacutainer for blood collection
- Bone marrow aspirate should be collected in a heparinized syringe
- Label the sample with patient ID and date of collection
- Transport the sample to the laboratory at ambient temperature (15-25°C) within 24 hours
- Do not refrigerate or freeze the sample
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Del(17p) is a high-risk cytogenetic abnormality in MM and CLL. Early detection via FISH is critical for risk stratification and treatment planning."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolyzed sample
- Incorrect container (e.g., EDTA tube)
- Sample received after 48 hours of collection
- Insufficient sample volume
- Unlabeled or mislabeled sample
Understanding Your Results
Negative
No deletion of TP53 gene detected. Standard risk disease. Conventional treatment may be effective.
Positive (low percentage, <20%)
Deletion present in a small fraction of cells. May indicate early clonal evolution. Close monitoring recommended.
Positive (high percentage, ≥20%)
Significant deletion of TP53 gene. High-risk disease. Targeted therapies or clinical trials should be considered.
Consult your oncologist if you have been diagnosed with MM or CLL and have not undergone Del(17p) testing. Also, consult if you experience new or worsening symptoms such as bone pain, fatigue, recurrent infections, or unexplained weight loss. Early detection of Del(17p) can significantly impact treatment decisions.
Limitations
- ⚠FISH only detects large deletions; point mutations in TP53 are not identified
- ⚠Results may be affected by the percentage of abnormal cells; a threshold of >5% is typically used
- ⚠Bone marrow sample is preferred over peripheral blood for higher sensitivity
- ⚠Test does not provide information on other chromosomal abnormalities
- ⚠Interpretation requires correlation with clinical and other laboratory findings
Risks & Considerations
- ●Bone marrow aspiration: risk of bleeding, infection, or discomfort at the site
- ●Blood draw: minimal risk of bruising or infection
- ●No radiation exposure from FISH testing
Interfering Factors
- ●Inadequate sample volume or poor quality DNA
- ●Hemolysis or clotting of blood sample
- ●Recent chemotherapy or radiation therapy may affect cell viability
- ●Low tumor cell burden in the sample may lead to false negative results
- ●Technical issues in FISH probe hybridization
Compare With Similar Tests
| Test | Del[17p(p53)] (MM, CLL) | FISH for del(13q) | TP53 mutation analysis | IgHV mutation status |
|---|---|---|---|---|
| Comparison | Del[17p(p53)] (MM, CLL) | Del(13q) is a favorable prognostic marker in CLL, while del(17p) is high-risk. Both are detected by FISH but have opposite prognostic implications. | FISH detects deletions, while sequencing identifies point mutations. Both are important as mutations can also inactivate p53. | IgHV mutation status is a prognostic marker in CLL, but it does not directly assess TP53. Combined testing provides comprehensive risk assessment. |
Frequently Asked Questions
What is Del[17p(p53)]?
Why is Del[17p(p53)] testing important?
What is the cost of Del[17p(p53)] test in India?
What sample is required for the test?
Do I need to fast before the test?
How long does it take to get results?
Is home sample collection available?
What does a positive Del(17p) result mean?
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Is the test covered by insurance?
What is the difference between FISH and karyotyping?
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