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DNA Labs India

Desmoglein (DSG) 1 & 3 Antibody Test

DNA Labs India | ISO 9001:2015 Certified

Desmoglein (DSG) 1 & 3 Antibody Test

Short Name: DSG 1 & 3 Antibody

Also known as: DSG 1 Antibody Test, DSG 3 Antibody Test, Desmoglein Antibody Test

Desmoglein (DSG) 1 & 3 Antibody Test test available at DNA Labs India for ₹13,000. Uses Immunofluorescence Assay (IFA) on Serum samples. Results in Reports available same day by 6 pm if sample received by 9 am on Tuesday or Friday.. Free home collection in 300+ cities across India.

Antibody Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose autoimmune skin disorders such as pemphigus vulgaris and pemphigus foliaceus by detecting antibodies against desmoglein proteins.

Test Code
487
Price
₹13,000
Sample Type
Serum
Result Time
Reports available same day by 6 pm if sample received by 9 am on Tuesday or Friday.
Fasting Required
Yes (8 hours)
Method
Immunofluorescence Assay (IFA)
Step 1

Sample Collection

Overnight fasting is preferred for accurate results. Avoid eating or drinking anything except water for 8-12 hours before the test.

Method: Blood draw

Step 2

Laboratory Analysis

A healthcare professional will draw blood from a vein in your arm using a sterile needle.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Avoid heavy lifting or strenuous activity for a few hours.

Timeline: Reports available same day by 6 pm if sample received by 9 am on Tuesday or Friday.

Patient Instructions

1
Before the Test:Overnight fasting is preferred. Inform your doctor about any medications or health conditions.
2
During the Test:A blood sample will be collected from your arm vein. The procedure takes a few minutes.
3
After the Test:You can resume normal activities immediately. Apply pressure to the site if needed.

About This Test

Who Should Get This Test

To diagnose autoimmune skin disorders such as pemphigus vulgaris and pemphigus foliaceus by detecting antibodies against desmoglein proteins.

How to Prepare

  • Collect 2 mL blood in a Serum Separator Tube (SST)
  • Centrifuge and separate serum
  • Ship refrigerated or frozen for stability

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is essential for diagnosing pemphigus and other autoimmune blistering diseases. Early detection can lead to better management and treatment outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume2 mL (1 mL min.)
ContainerSST (Serum Separator Tube)
Collection MethodBlood draw

Sample Stability

Room Temperature: 6 hours
Refrigerator: 1 week
Frozen: 2 weeks
Sample Rejection Criteria:
  • Insufficient sample volume
  • Improper storage or transport conditions
  • Hemolyzed or clotted sample

Understanding Your Results

Results are interpreted based on the presence or absence of desmoglein antibodies. Positive results indicate an autoimmune response against skin proteins, which can help diagnose specific conditions.
📊

Negative

No significant antibodies detected; low likelihood of pemphigus. Consult a doctor if symptoms persist.

📊

Positive for Desmoglein 1 Antibodies

May indicate pemphigus foliaceus. Further evaluation by a dermatologist is recommended.

📊

Positive for Desmoglein 3 Antibodies

May indicate pemphigus vulgaris. Seek immediate medical attention for treatment planning.

📊

Positive for both Desmoglein 1 and 3 Antibodies

Suggests a combination or severe form of pemphigus. Urgent specialist consultation is advised.

⚠️ When to Consult a Doctor:

Consult a dermatologist or immunologist if the test is positive, or if you experience persistent symptoms like blisters, sores, or oral lesions, for proper diagnosis and treatment.

Limitations

  • ⚠May not detect all antibody subtypes
  • ⚠False positives possible in other autoimmune conditions
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minor bruising at the puncture site
  • ●Slight risk of infection
  • ●Dizziness or lightheadedness

Interfering Factors

  • ●Hemolyzed samples
  • ●Lipemic samples
  • ●Recent blood transfusion

Frequently Asked Questions

What is the Desmoglein 1 & 3 Antibody Test?
It is a blood test that detects antibodies against desmoglein proteins, which are associated with autoimmune skin disorders like pemphigus.
Why is this test performed?
To diagnose conditions such as pemphigus vulgaris and pemphigus foliaceus, which cause blistering and sores on the skin or mucous membranes.
How should I prepare for the test?
Overnight fasting is preferred for 8-12 hours. Avoid food and drinks except water before sample collection.
What is the cost of the test in India?
The cost is INR 13000, with free home sample collection available in many cities across India.
How is the sample collected?
A healthcare professional draws 2 mL of blood from a vein in your arm using a sterile needle and collects it in a Serum Separator Tube (SST).
When will I get the results?
Results are typically available same day by 6 pm if the sample is received by 9 am on Tuesday or Friday.
What do positive results mean?
Positive results indicate the presence of desmoglein antibodies, suggesting an autoimmune skin disorder. Consult a doctor for diagnosis and treatment.
Are there any risks associated with the test?
The test is safe with minimal risks, such as minor bruising or slight infection at the puncture site.
Is home collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
Does insurance cover this test?
Coverage depends on your insurance plan. Check with your provider to understand out-of-pocket expenses.
What conditions can this test diagnose?
It helps diagnose autoimmune blistering disorders like pemphigus vulgaris and pemphigus foliaceus.
How accurate is this test?
The test is highly accurate for detecting desmoglein antibodies, but results should be interpreted alongside clinical symptoms by a healthcare provider.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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