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DNA Labs India

FISH - 14q32.3 or LSI IGH Gene Breakapart Test

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FISH - 14q32.3 or LSI IGH Gene Breakapart Test

Also known as: LSI IGH Gene Breakapart Test, IGH FISH Test

FISH - 14q32.3 or LSI IGH Gene Breakapart Test test available at DNA Labs India for ₹6,000. Uses FISH on Whole blood or Bone Marrow samples. Results in 4 days. Free home collection in 300+ cities across India.

FISH🏠 Home Collection

🩺 Medically Reviewed By

Overview

To detect IGH gene rearrangements on chromosome 14 for diagnosis and prognostic evaluation in leukemias.

Test Code
562
Price
₹6,000
Sample Type
Whole blood or Bone Marrow
Result Time
4 days
Fasting Required
No
Method
FISH
Step 1

Sample Collection

Ensure the Chromosome & FISH analysis Requisition Form (Form 17) is duly filled.

Method: Venipuncture or Bone Marrow Aspiration

Step 2

Laboratory Analysis

Sample collected via venipuncture for blood or bone marrow aspiration, as per physician guidance.

Step 3

Report Delivery

Sample must be stored and shipped at 18-22°C; do not freeze.

Timeline: 4 days

Patient Instructions

1
Before the Test:Consult with your physician, complete the requisition form, and arrange for sample collection.
2
During the Test:The sample is processed in the lab using FISH technique to analyze the IGH gene.
3
After the Test:Results are reviewed and reported; discuss findings with your doctor.

About This Test

Who Should Get This Test

To detect IGH gene rearrangements on chromosome 14 for diagnosis and prognostic evaluation in leukemias.

How to Prepare

  • Collect 5 mL whole blood or 4 mL bone marrow in 2 Green Top (Sodium Heparin) tubes.
  • Ship at 18-22°C. DO NOT FREEZE.
  • Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This FISH test is vital for detecting IGH gene rearrangements, aiding in accurate leukemia diagnosis and treatment decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood or Bone Marrow
Sample Volume5 mL whole blood or 4 mL Bone Marrow
ContainerGreen Top (Sodium Heparin) tubes
Collection MethodVenipuncture or Bone Marrow Aspiration

Sample Stability

Room Temperature: 48 hrs
Refrigerator: Not applicable
Frozen: Not applicable
Sample Rejection Criteria:
  • Incorrect sample type
  • Insufficient sample volume
  • Missing or incomplete requisition form
  • Frozen sample

Understanding Your Results

Results indicate whether IGH gene rearrangements are present, aiding in leukemia diagnosis.
Positive: IGH gene rearrangement detected, suggestive of leukemia; clinical correlation is essential.
Negative: No IGH gene rearrangement detected; further tests may be needed if symptoms persist.
Results should be interpreted by a hematologist or oncologist in conjunction with clinical findings.
⚠️ When to Consult a Doctor:

Consult a hematologist or oncologist if you experience symptoms like unexplained weight loss, fatigue, swollen lymph nodes, or if recommended by your physician.

Limitations

  • Detects only specific IGH gene rearrangements
  • May not identify all genetic variants
  • Requires specialized laboratory equipment

Risks & Considerations

  • Minimal risk from blood draw, such as bruising or infection
  • Bone marrow aspiration may cause minor pain or discomfort

Interfering Factors

  • Poor sample quality
  • Contamination during collection
  • Technical errors in FISH processing

Frequently Asked Questions

What is the FISH - 14q32.3 or LSI IGH Gene Breakapart Test?
It is a genetic test using Fluorescence In Situ Hybridization (FISH) to detect abnormalities in the IGH gene on chromosome 14, often used in leukemia diagnosis.
Why is this test performed?
To identify IGH gene rearrangements for diagnosing leukemias like acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML), and for prognostic assessment.
What are the symptoms of IGH gene abnormalities?
Common symptoms include unexplained weight loss, fatigue, swollen lymph nodes, night sweats, recurrent infections, bone pain, and anemia.
How is the test conducted?
The test analyzes blood or bone marrow samples using FISH technique to detect specific DNA sequences related to the IGH gene.
What sample is required for the test?
5 mL whole blood or 4 mL bone marrow collected in Green Top (Sodium Heparin) tubes.
Is fasting required before the test?
No, fasting is not required, but a duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
How long does it take to get results?
Reports are typically available within 4 days after sample collection.
What do positive and negative results mean?
Positive results indicate IGH gene rearrangement, suggesting leukemia; negative results mean no rearrangement detected. Clinical correlation is necessary.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw or discomfort from bone marrow aspiration.
Is home collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings across India.
What is the cost of the test?
The test costs INR 6000.0, with home collection included at no extra charge.
How should I prepare for the test?
Ensure the requisition form is filled, and follow sample collection instructions. No special preparation like fasting is needed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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