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DNA Labs India

FISH - BCL6 (3q27) Gene Rearrangement Test

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FISH - BCL6 (3q27) Gene Rearrangement Test

Short Name: FISH BCL6 Test

Also known as: FISH BCL6 Test, BCL6 Gene Rearrangement Test, FISH for BCL6 Rearrangement

FISH - BCL6 (3q27) Gene Rearrangement Test test available at DNA Labs India for ₹7,020. Uses Fluorescence In Situ Hybridization (FISH) on Formalin Fixed Paraffin Embedded Tissue Block or Whole Blood or Bone Marrow samples. Results in Results are typically available within 4 working days after sample receipt at the laboratory.. Free home collection in 300+ cities across India.

Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect BCL6 gene rearrangements for diagnosing and sub-classifying B-cell lymphomas, aiding in treatment planning and prognosis assessment.

Test Code
574
Price
₹7,020
Sample Type
Formalin Fixed Paraffin Embedded Tissue Block or Whole Blood or Bone Marrow
Result Time
Results are typically available within 4 working days after sample receipt at the laboratory.
Fasting Required
No
Method
Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

Ensure the Chromosome & FISH analysis Requisition Form (Form 17) is duly filled and signed by the referring physician.

Method: Biopsy or Venipuncture

Step 2

Laboratory Analysis

For tissue: collect via biopsy under local anesthesia. For blood/bone marrow: standard collection procedures with anticoagulant.

Step 3

Report Delivery

Ship sample at specified temperatures within 48 hours. Do not freeze tissue blocks to prevent degradation.

Timeline: Results are typically available within 4 working days after sample receipt at the laboratory.

Patient Instructions

1
Before the Test:No specific preparation is required, but ensure the requisition form is completed and signed by the referring specialist.
2
During the Test:Sample collection will be performed by a trained healthcare professional. For biopsies, local anesthesia may be administered to minimize discomfort.
3
After the Test:Resume normal activities promptly. Mild soreness or bruising at the collection site may occur and typically resolves within a few days.

About This Test

Who Should Get This Test

To detect BCL6 gene rearrangements for diagnosing and sub-classifying B-cell lymphomas, aiding in treatment planning and prognosis assessment.

How to Prepare

  • Submit formalin fixed paraffin embedded tissue block with at least 10% tumor tissue.
  • Alternatively, provide 4 mL whole blood or 4 mL bone marrow in a Green Top (Sodium Heparin) tube.
  • Ship tissue blocks at room temperature; ship blood/bone marrow at 18-22°C.
  • Do not freeze the samples under any circumstances.
  • Include the duly filled Chromosome & FISH analysis Requisition Form (Form 17) with the sample.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"The FISH BCL6 test is essential for precise diagnosis and prognosis of B-cell lymphomas, helping tailor treatment plans for better patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeFormalin Fixed Paraffin Embedded Tissue Block or Whole Blood or Bone Marrow
Sample VolumeTissue block with 10% tumor tissue, or 4 mL whole blood, or 4 mL bone marrow
ContainerGreen Top (Sodium Heparin) tube or Formalin Fixed Paraffin Embedded Tissue Block
Collection MethodBiopsy or Venipuncture

Sample Stability

Tissue block: stable at room temperature for 48 hours when shipped promptly.
Blood/Bone Marrow: stable at 18-22°C for 48 hours.
Avoid exposure to extreme temperatures or freezing to ensure sample integrity.
Sample Rejection Criteria:
  • Sample without adequate tumor tissue content
  • Missing or improperly filled requisition form
  • Sample not shipped within specified temperature or time frame
  • Frozen tissue block samples that may compromise FISH analysis

Understanding Your Results

Results indicate the presence or absence of BCL6 gene rearrangements, which are key markers in B-cell lymphoma diagnosis and prognosis.
Positive result: BCL6 gene rearrangement detected, strongly associated with B-cell lymphomas like DLBCL or follicular lymphoma.
Negative result: No BCL6 gene rearrangement detected, suggesting other lymphoma subtypes or non-lymphoma conditions.
Results must be interpreted in the context of clinical history, histopathological findings, and other genetic tests for comprehensive diagnosis.
⚠️ When to Consult a Doctor:

Consult an oncologist immediately if symptoms like persistent swollen lymph nodes, fever, night sweats, or unexplained weight loss are present, or if test results are positive for BCL6 rearrangement.

Limitations

  • ⚠Test is specific to BCL6 rearrangements; other genetic alterations may require additional tests.
  • ⚠Results should be correlated with clinical findings, histopathology, and other diagnostic tests.

Risks & Considerations

  • ●Minor bleeding or infection at the biopsy site
  • ●Rare allergic reaction to anesthesia during biopsy
  • ●Discomfort or bruising from blood draw

Interfering Factors

  • ●Poor sample quality
  • ●Insufficient tumor tissue in sample
  • ●Improper sample handling or storage conditions

Frequently Asked Questions

What is the FISH BCL6 gene rearrangement test?
It is a genetic test that uses fluorescence in situ hybridization to detect rearrangements in the BCL6 gene, which are associated with B-cell lymphomas like DLBCL and follicular lymphoma.
Why is this test recommended by doctors?
Doctors recommend this test to diagnose, sub-classify, and assess prognosis in B-cell lymphomas, which helps in planning appropriate treatment strategies.
What types of samples are needed for the test?
The test requires formalin fixed paraffin embedded tissue blocks (with 10% tumor tissue), or 4 mL whole blood, or 4 mL bone marrow in a Sodium Heparin tube.
Is fasting required before giving a sample for this test?
No, fasting is not required. However, a duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
How much does the FISH BCL6 test cost in India?
The test costs INR 7020 at DNA Labs India, with free home sample collection available across many cities in India.
How long does it take to receive the test results?
Results are typically available within 4 working days after the sample is received at the laboratory.
Does DNA Labs India offer home sample collection for this test?
Yes, DNA Labs India provides free home sample collection for online bookings, available in numerous cities across India.
What symptoms might suggest the need for this genetic test?
Symptoms such as swollen lymph nodes, fever, night sweats, unexplained weight loss, fatigue, itching, shortness of breath, chest pain, or abdominal swelling may indicate the need for testing.
What does a positive BCL6 rearrangement result mean?
A positive result indicates the presence of BCL6 gene rearrangement, which is commonly associated with B-cell lymphomas and may influence treatment decisions and prognosis.
How should I proceed after receiving the test results?
Discuss the results with your oncologist or healthcare provider to understand their implications and plan any necessary follow-up tests or treatments.
Are there any risks involved in this test?
The test itself is low-risk; potential risks are related to sample collection, such as minor bleeding, infection, or discomfort at the biopsy or blood draw site.
How accurate is the FISH BCL6 gene rearrangement test?
FISH is a highly accurate and specific technique for detecting gene rearrangements, but results should always be interpreted alongside clinical and histopathological findings for comprehensive diagnosis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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