FISH - C-MYC Amplification Test
Short Name: C-MYC Amplification FISH Test
Also known as: C-MYC gene amplification test, FISH for C-MYC, C-MYC FISH assay
FISH - C-MYC Amplification Test test available at DNA Labs India for ₹6,000. Uses FISH on Whole blood or bone marrow samples. Results in Report available in 4 days from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of the FISH - C-MYC Amplification Test is to detect the amplification of the C-MYC gene, which is a key biomarker associated with aggressive cancers, especially Burkitt lymphoma and other lymphomas. This test helps in confirming diagnoses, guiding treatment decisions, monitoring disease progression, and assessing response to therapy. By identifying genetic alterations, it supports personalized medicine approaches and improves clinical outcomes for cancer patients.
- Test Code
- 577
- Price
- ₹6,000
- Sample Type
- Whole blood or bone marrow
- Result Time
- Report available in 4 days from sample receipt
- Fasting Required
- No
- Method
- FISH
Sample Collection
Ensure the Chromosome & FISH analysis Requisition Form (Form 17) is duly filled. Avoid freezing samples. Confirm patient details and sample requirements with the healthcare provider.
Method: Blood draw or bone marrow aspiration
Laboratory Analysis
Collect 5 mL whole blood or 4 mL bone marrow in Green Top (Sodium Heparin) tubes using aseptic technique. Label tubes accurately with patient information.
Report Delivery
Ship samples at 18-22°C immediately. Do not freeze. Store at room temperature for up to 48 hours before analysis.
Timeline: Report available in 4 days from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the FISH - C-MYC Amplification Test is to detect the amplification of the C-MYC gene, which is a key biomarker associated with aggressive cancers, especially Burkitt lymphoma and other lymphomas. This test helps in confirming diagnoses, guiding treatment decisions, monitoring disease progression, and assessing response to therapy. By identifying genetic alterations, it supports personalized medicine approaches and improves clinical outcomes for cancer patients.
How to Prepare
- Fill the mandatory Chromosome & FISH analysis Requisition Form (Form 17)
- Collect blood or bone marrow in specified tubes
- Maintain sample at 18-22°C during transport
- Avoid freezing the sample
- Ship samples daily to arrive by 4 pm for processing
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Early detection of C-MYC amplification through FISH testing is crucial for diagnosing lymphomas and guiding targeted therapy, improving patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample in non-heparin tubes
- Insufficient sample volume
- Frozen or improperly stored samples
- Missing or incomplete requisition form
- Hemolyzed or contaminated samples
Understanding Your Results
Positive for C-MYC amplification
Amplification detected, associated with Burkitt lymphoma and other aggressive cancers. Clinical correlation and specialist consultation recommended.
Negative for C-MYC amplification
No amplification detected, but does not rule out other genetic abnormalities. Clinical context and additional tests may be needed.
Inconclusive
Insufficient sample or technical issues. Repeat testing or alternative diagnostics may be required.
Consult a doctor if you experience symptoms like unexplained weight loss, fatigue, persistent pain, or changes in bowel habits, especially with a family history of cancer. Also, consult if test results are positive or inconclusive for further evaluation and management.
Limitations
- ⚠Test only detects C-MYC amplification, not other mutations or rearrangements
- ⚠Requires adequate viable tissue or cell samples
- ⚠False negatives possible if amplification is low-level
- ⚠Not suitable for screening in asymptomatic individuals
Risks & Considerations
- ●Minimal risk from blood draw: bruising, infection, or pain at site
- ●Bone marrow aspiration may involve higher discomfort and rare complications like bleeding or infection
Interfering Factors
- ●Improper sample collection or handling
- ●Contamination of sample
- ●Use of incorrect anticoagulant (non-heparin tubes)
- ●Delayed sample shipment affecting stability
Frequently Asked Questions
What is the FISH - C-MYC Amplification Test?
What is the cost of the FISH - C-MYC Amplification Test at DNA Labs India?
What samples are required for this test?
Is fasting required before the test?
How long does it take to get the results?
What are the symptoms that may indicate the need for this test?
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What does a positive result mean?
Are there any risks associated with the test?
Can this test be used for cancer screening?
What should I do if my test results are inconclusive?
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