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FISH - Eosinophilic Leukemia Panel Test

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FISH - Eosinophilic Leukemia Panel Test

Short Name: FISH Eosinophilic Leukemia Panel

Also known as: FISH for Eosinophilic Leukemia, Eosinophilia FISH Panel, Genetic Panel for Eosinophilia

FISH - Eosinophilic Leukemia Panel Test test available at DNA Labs India for ₹17,000. Uses Fluorescence In Situ Hybridization (FISH) on Whole Blood or Bone Marrow samples. Results in 4 Working days from sample receipt. Free home collection in 300+ cities across India.

FISHAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The FISH - Eosinophilic Leukemia Panel is designed to detect specific genetic mutations associated with eosinophilic leukemia. It targets genes including PDGFRA (4q12), PDGFRB (5q33), FGFR1 (8p12), and CBFB (inv16). Identifying these abnormalities helps in confirming the diagnosis, differentiating from other conditions, predicting disease progression, and selecting appropriate targeted therapies such as tyrosine kinase inhibitors.

Test Code
580
Price
₹17,000
Sample Type
Whole Blood or Bone Marrow
Result Time
4 Working days from sample receipt
Fasting Required
No
Method
Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

Ensure the Chromosome & FISH analysis Requisition Form (Form 17) is duly filled. No fasting required. Inform the healthcare provider about any medications or recent treatments.

Method: Venipuncture for blood; bone marrow aspiration for bone marrow

Step 2

Laboratory Analysis

For blood sample: Venipuncture will be performed to collect 5 mL of blood into Sodium Heparin tubes. For bone marrow: Aspiration will be done to collect 4 mL of marrow. The process is quick and may cause minimal discomfort.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Sample is shipped at 18-22°C; do not freeze. Avoid strenuous activity if bone marrow was aspirated. Results will be available in 4 working days.

Timeline: 4 Working days from sample receipt

Patient Instructions

1
Before the Test:No special preparation required. Ensure the Requisition Form is completed and sample is collected properly.
2
During the Test:Sample collection takes 10-20 minutes. For blood, a needle is inserted into a vein; for bone marrow, a needle is inserted into the hip bone.
3
After the Test:Mild soreness at the collection site may occur. Results are processed in the lab and delivered within 4 working days.

About This Test

Who Should Get This Test

The FISH - Eosinophilic Leukemia Panel is designed to detect specific genetic mutations associated with eosinophilic leukemia. It targets genes including PDGFRA (4q12), PDGFRB (5q33), FGFR1 (8p12), and CBFB (inv16). Identifying these abnormalities helps in confirming the diagnosis, differentiating from other conditions, predicting disease progression, and selecting appropriate targeted therapies such as tyrosine kinase inhibitors.

How to Prepare

  • Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
  • Use 2 Green Top (Sodium Heparin) tubes for sample collection
  • Ship at 18-22°C; do not freeze
  • Label samples with patient details and test name
  • For bone marrow collection, follow sterile technique

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This FISH panel is essential for diagnosing eosinophilic leukemia and identifying specific genetic abnormalities to guide targeted therapy and predict treatment response."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood or Bone Marrow
Sample Volume5 mL whole blood (min 3 mL) or 4 mL bone marrow (min 2 mL)
ContainerSodium Heparin tubes (Green Top)
Collection MethodVenipuncture for blood; bone marrow aspiration for bone marrow

Sample Stability

Room Temperature
Refrigerator
Frozen
Sample Rejection Criteria:
  • Sample not collected in Sodium Heparin tubes
  • Sample frozen or stored at incorrect temperature
  • Insufficient sample volume
  • Missing or incomplete Requisition Form (Form 17)
  • Hemolyzed or contaminated sample

Understanding Your Results

Results from the FISH - Eosinophilic Leukemia Panel indicate the presence or absence of specific genetic abnormalities. A positive result for any gene rearrangement or mutation supports the diagnosis of eosinophilic leukemia and may guide treatment. Negative results suggest no detectable abnormalities, but clinical correlation is essential.
📊

Positive for PDGFRA rearrangement

Indicates eosinophilic leukemia associated with PDGFRA mutation; may respond to specific TKIs like imatinib

📊

Positive for PDGFRB rearrangement

Suggests eosinophilic leukemia linked to PDGFRB mutation; targeted therapy options available

📊

Positive for FGFR1 rearrangement

Associated with aggressive eosinophilic leukemia; prognosis may vary

📊

Positive for CBFB (inv16)

Indicates acute myeloid leukemia with eosinophilia; treatment may differ

📊

Negative for all abnormalities

No detected mutations; further tests may be needed if clinical suspicion remains

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms such as persistent fatigue, unexplained fever, weight loss, enlarged lymph nodes, or night sweats. Also, seek medical advice if your blood tests show high eosinophil counts or if you have a family history of eosinophilic disorders. After receiving test results, discuss them with an oncologist for appropriate management.

Limitations

  • ⚠This test detects only specified genetic abnormalities; other mutations may not be identified
  • ⚠False negatives can occur if the sample has insufficient tumor cells
  • ⚠Not a standalone diagnostic tool; must be correlated with clinical and pathological findings
  • ⚠Limited to eosinophilic leukemia-associated genes; does not cover all leukemia types

Risks & Considerations

  • ●Mild pain or bruising at blood collection site
  • ●Rare risk of infection or excessive bleeding from bone marrow aspiration
  • ●Minimal discomfort during procedure

Interfering Factors

  • ●Contaminated or improperly stored samples
  • ●Use of fixatives other than Sodium Heparin
  • ●Low cellularity in bone marrow samples
  • ●Recent chemotherapy or radiation therapy affecting cell DNA

Compare With Similar Tests

TestFISH - Eosinophilic Leukemia Panel Test
ComparisonFISH - Eosinophilic Leukemia Panel Test

Frequently Asked Questions

What is the FISH - Eosinophilic Leukemia Panel Test?
It is a genetic test that uses FISH technology to detect specific gene abnormalities like PDGFRA, PDGFRB, FGFR1, and CBFB to diagnose eosinophilic leukemia.
What is the cost of the test?
The test costs INR 17000 at DNA Labs India, with free home collection available in many cities across India.
What are the symptoms that indicate this test?
Symptoms include fatigue, fever, weight loss, enlarged lymph nodes, night sweats, or unexplained high eosinophil counts in blood tests.
How is the sample collected?
A blood sample (5 mL) or bone marrow sample (4 mL) is collected in Sodium Heparin tubes and shipped at 18-22°C without freezing.
Is fasting required for this test?
No, fasting is not required for the FISH - Eosinophilic Leukemia Panel Test.
How long does it take to get results?
Results are typically available within 4 working days after sample collection.
What does a positive result mean?
A positive result indicates the presence of a genetic abnormality associated with eosinophilic leukemia, which helps in diagnosis and treatment planning.
Is home collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
Who should take this test?
Individuals with symptoms of leukemia, unexplained eosinophilia, or those under evaluation by an oncologist or hematologist.
What is the significance of the genes tested?
Genes like PDGFRA, PDGFRB, FGFR1, and CBFB are commonly mutated in eosinophilic leukemia, and their detection guides targeted therapy.
Are there any risks associated with this test?
Risks are minimal, including mild pain or bruising at the collection site; bone marrow aspiration carries a small risk of infection or bleeding.
How should I prepare for the test?
Fill the mandatory Requisition Form (Form 17) and inform your doctor about any medications. No other preparation is needed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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