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FISH for Pre or Postnatal Diagnosis Chromosome 13 22 Test

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FISH for Pre or Postnatal Diagnosis Chromosome 13 22 Test

Short Name: FISH Chr 13/22

Also known as: FISH Chromosome 13/22, Prenatal FISH 13/22, Postnatal FISH 13/22

FISH for Pre or Postnatal Diagnosis Chromosome 13 22 Test test available at DNA Labs India for ₹7,000. Uses Fluorescence in situ Hybridization (FISH) on Amniotic fluid, Chorionic villi, Cord blood, Peripheral blood samples. Results in Reports are typically available within 10-12 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

Molecular CytogeneticsPrenatal (fetus) or Postnatal (newborn)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The primary purpose of FISH for chromosomes 13 and 22 is to detect numerical abnormalities (aneuploidies) that may cause genetic disorders. It is often used as a rapid screening tool when there is clinical suspicion of trisomy 13 or 22 based on ultrasound findings, maternal age, or previous history. The test provides quick results compared to traditional karyotyping, which is essential for prenatal decisions. It also helps in confirming postnatal diagnoses in newborns with dysmorphic features or congenital anomalies.

Test Code
6286
CPT Code
88271
ICD Code
Z36.89
Price
₹7,000
Sample Type
Amniotic fluid, Chorionic villi, Cord blood, Peripheral blood
Result Time
Reports are typically available within 10-12 days after the sample reaches the laboratory.
Fasting Required
No
Method
Fluorescence in situ Hybridization (FISH)
Step 1

Sample Collection

No special preparation required. For prenatal samples, the procedure (amniocentesis/CVS) will be performed by a qualified obstetrician. For postnatal blood samples, no fasting is needed.

Method: Venipuncture or amniocentesis/CVS by trained professional

Step 2

Laboratory Analysis

For blood samples, standard venipuncture is performed. For amniocentesis/CVS, a sterile procedure is done under ultrasound guidance. The process is quick and generally well-tolerated.

Step 3

Report Delivery

After blood collection, apply pressure to the puncture site. For prenatal procedures, rest for a short period and follow the doctor's advice. Report any unusual symptoms such as bleeding or fever.

Timeline: Reports are typically available within 10-12 days after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:No special preparation. For prenatal sampling, the doctor will explain the procedure and obtain consent.
2
During the Test:For blood: a simple blood draw. For amniocentesis/CVS: a needle is inserted into the amniotic sac or placenta under ultrasound guidance.
3
After the Test:You may resume normal activities. For prenatal procedures, avoid strenuous activity for 24 hours and watch for complications.

About This Test

Who Should Get This Test

The primary purpose of FISH for chromosomes 13 and 22 is to detect numerical abnormalities (aneuploidies) that may cause genetic disorders. It is often used as a rapid screening tool when there is clinical suspicion of trisomy 13 or 22 based on ultrasound findings, maternal age, or previous history. The test provides quick results compared to traditional karyotyping, which is essential for prenatal decisions. It also helps in confirming postnatal diagnoses in newborns with dysmorphic features or congenital anomalies.

How to Prepare

  • Prenatal samples must be collected by a qualified obstetrician
  • Blood samples should be collected in EDTA vacutainer
  • Amniotic fluid should be collected in a sterile container
  • Samples should be transported to the lab at room temperature within 48 hours
  • Do not refrigerate or freeze samples

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"FISH testing for chromosomes 13 and 22 is a rapid and reliable method for detecting aneuploidies in prenatal and postnatal samples. Early diagnosis allows for informed counseling and timely management."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeAmniotic fluid, Chorionic villi, Cord blood, Peripheral blood
Sample Volume5-10 mL blood or 10-15 mL amniotic fluid
ContainerEDTA vacutainer (blood) or sterile tube (amniotic fluid)
Collection MethodVenipuncture or amniocentesis/CVS by trained professional

Sample Stability

Room Temperature
Refrigerated
Frozen
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Samples received after 48 hours at room temperature
  • Improperly labeled samples
  • Maternal cell contamination in prenatal samples

Understanding Your Results

The FISH test for chromosomes 13 and 22 provides a rapid assessment of the copy number of these chromosomes. Results are reported as normal (2 copies) or abnormal (1, 3, or more copies). An abnormal result indicates aneuploidy, which may be associated with clinical conditions.
📊

Normal (2 copies each)

No evidence of trisomy 13 or 22. However, other chromosomal abnormalities cannot be excluded.

📊

Trisomy 13 (3 copies)

Indicates Patau syndrome, associated with severe intellectual disability, cleft lip/palate, heart defects, and early death.

📊

Trisomy 22 (3 copies)

Rare, often lethal in early pregnancy; survivors may have severe developmental delay and congenital anomalies.

📊

Monosomy (1 copy)

Rare, usually lethal; may be seen in mosaic form.

⚠️ When to Consult a Doctor:

If you receive an abnormal FISH result, it is essential to consult with a genetic counselor or a specialist in maternal-fetal medicine to discuss the implications, further testing options, and management strategies.

Limitations

  • ⚠FISH only detects targeted chromosomal regions; it does not detect structural rearrangements or other chromosomal abnormalities
  • ⚠Mosaic trisomy may be missed if the abnormal cell line is below the detection threshold
  • ⚠Results should be confirmed by karyotyping or chromosomal microarray for definitive diagnosis
  • ⚠Not a substitute for comprehensive genetic counseling

Risks & Considerations

  • ●For amniocentesis/CVS: small risk of miscarriage (0.1-0.3%)
  • ●Bleeding or infection at the puncture site
  • ●Discomfort or cramping

Interfering Factors

  • ●Maternal cell contamination in prenatal samples
  • ●Poor sample quality or insufficient cells
  • ●Inadequate fixation or hybridization
  • ●Recent blood transfusion (for postnatal blood samples)

Compare With Similar Tests

TestFISH for Pre or Postnatal Diagnosis Chromosome 13 22KaryotypingChromosomal Microarray (CMA)NIPT (Non-Invasive Prenatal Testing)
ComparisonFISH for Pre or Postnatal Diagnosis Chromosome 13 22

Frequently Asked Questions

What is FISH for chromosome 13 and 22?
FISH (Fluorescence in situ Hybridization) is a molecular technique that uses fluorescent probes to detect specific DNA sequences on chromosomes. This test specifically looks for extra or missing copies of chromosomes 13 and 22, which can cause genetic disorders.
Why is this test done prenatally?
Prenatal FISH is performed to quickly detect aneuploidies like Trisomy 13 or 22 in a fetus, especially when ultrasound findings or maternal age suggest an increased risk. Early diagnosis helps in making informed decisions about pregnancy management.
What is the cost of the test?
The test costs INR 7000 at DNA Labs India. This includes the test and interpretation by a genetic counselor. Free home sample collection is available for online bookings.
What sample is required?
For prenatal diagnosis, amniotic fluid, chorionic villi, or cord blood may be used. For postnatal diagnosis, a peripheral blood sample is taken.
Is fasting required?
No, fasting is not required for this test.
How long does it take to get results?
Results are typically available within 10-12 days after the sample is received by the laboratory.
Is the test safe for the fetus?
The FISH test itself is non-invasive, but the sample collection (amniocentesis/CVS) carries a small risk of miscarriage (0.1-0.3%). This risk is discussed with your doctor before the procedure.
What does an abnormal result mean?
An abnormal result indicates an extra or missing copy of chromosome 13 or 22. For example, Trisomy 13 (Patau syndrome) is associated with severe birth defects. Your genetic counselor will explain the implications.
Can this test detect all chromosomal abnormalities?
No, FISH only detects abnormalities in the specific chromosomes tested (13 and 22). Other chromosomal issues may require karyotyping or microarray.
Do I need a doctor's prescription?
Yes, a doctor's prescription is required. Additionally, a duly filled Prenatal Genetic Testing Consent Form (Form 18) and Chromosome & FISH analysis Requisition Form (Form 17) are mandatory.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in over 200 cities across India. You can book online and a phlebotomist will visit your location.
How accurate is the FISH test?
FISH is highly accurate for detecting the targeted aneuploidies, with sensitivity and specificity above 95%. However, results should be confirmed with karyotyping or CMA for definitive diagnosis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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