FISH for Pre or Postnatal Diagnosis Chromosome 13 23 Test
Short Name: FISH Chr 13/23
Also known as: FISH Chromosome 13/23, Prenatal FISH for Trisomy 13 and Sex Chromosomes, FISH Aneuploidy Detection
FISH for Pre or Postnatal Diagnosis Chromosome 13 23 Test test available at DNA Labs India for ₹7,000. Uses Fluorescence in situ Hybridization (FISH) on Amniotic fluid, Chorionic villus sample (CVS), or Peripheral blood samples. Results in Reports are typically available within 10-12 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of FISH for chromosomes 13 and 23 is to detect aneuploidies (abnormal number of chromosomes) that can lead to significant developmental and health issues. Specifically, it identifies Trisomy 13 (Patau syndrome), a severe condition characterized by intellectual disability, heart defects, and other organ malformations. Additionally, it detects sex chromosome abnormalities such as Turner syndrome (monosomy X), Klinefelter syndrome (XXY), Triple X syndrome (XXX), and XYY syndrome. Early detection through prenatal testing allows parents and healthcare providers to prepare for the medical and supportive needs of the child, or to make informed decisions about the pregnancy. In postnatal cases, FISH can help diagnose genetic conditions in individuals presenting with developmental delays, infertility, or other clinical features suggestive of chromosomal abnormalities.
- Test Code
- 6288
- CPT Code
- 88271
- ICD Code
- Z36.89
- Price
- ₹7,000
- Sample Type
- Amniotic fluid, Chorionic villus sample (CVS), or Peripheral blood
- Result Time
- Reports are typically available within 10-12 days after sample collection.
- Fasting Required
- No
- Method
- Fluorescence in situ Hybridization (FISH)
Sample Collection
Duly filled Prenatal Genetic Testing Consent Form (Form 18) & Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. No fasting required.
Method: Venipuncture or amniocentesis/CVS by qualified professional
Laboratory Analysis
For prenatal samples, amniocentesis or CVS is performed by an obstetrician under ultrasound guidance. For blood samples, a standard venipuncture is done.
Report Delivery
No specific precautions. Patients may resume normal activities. For prenatal procedures, rest and monitoring for any complications are advised.
Timeline: Reports are typically available within 10-12 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of FISH for chromosomes 13 and 23 is to detect aneuploidies (abnormal number of chromosomes) that can lead to significant developmental and health issues. Specifically, it identifies Trisomy 13 (Patau syndrome), a severe condition characterized by intellectual disability, heart defects, and other organ malformations. Additionally, it detects sex chromosome abnormalities such as Turner syndrome (monosomy X), Klinefelter syndrome (XXY), Triple X syndrome (XXX), and XYY syndrome. Early detection through prenatal testing allows parents and healthcare providers to prepare for the medical and supportive needs of the child, or to make informed decisions about the pregnancy. In postnatal cases, FISH can help diagnose genetic conditions in individuals presenting with developmental delays, infertility, or other clinical features suggestive of chromosomal abnormalities.
How to Prepare
- Ensure all required forms are completed and signed
- For amniocentesis, the procedure is done after 15 weeks of gestation
- For CVS, the procedure is done between 10-13 weeks of gestation
- Blood samples should be collected in EDTA tube and transported at room temperature
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"FISH for chromosomes 13 and 23 is a rapid and reliable method for detecting common aneuploidies, especially in high-risk pregnancies. Early diagnosis allows for informed decision-making and appropriate management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Incorrect labeling or missing consent forms
- Samples received after 48 hours of collection
Understanding Your Results
3 signals for chromosome 13
Indicates Patau syndrome, associated with severe developmental delay and multiple congenital anomalies
1 signal for X, 0 for Y
Monosomy X, associated with short stature, ovarian dysfunction, and cardiac anomalies
2 signals for X, 1 for Y
Extra X chromosome in males, associated with infertility, learning difficulties, and gynecomastia
3 signals for X, 0 for Y
Extra X chromosome in females, often mild or asymptomatic
1 signal for X, 2 for Y
Extra Y chromosome in males, usually tall stature and normal intelligence
Consult your healthcare provider if you have any concerns about your pregnancy or your child's development. Genetic counseling is recommended before and after the test to understand the implications of the results.
Limitations
- ⚠FISH only detects specific aneuploidies for the tested chromosomes; it does not detect structural abnormalities or other chromosomal imbalances
- ⚠Results should be confirmed by conventional karyotyping or chromosomal microarray analysis
- ⚠Low-level mosaicism may not be detected
- ⚠Not a substitute for comprehensive genetic counseling
Risks & Considerations
- ●For amniocentesis/CVS: small risk of miscarriage (0.1-0.3%)
- ●Bleeding or infection at the puncture site
- ●Fetal injury (rare)
Interfering Factors
- ●Maternal cell contamination in prenatal samples (amniotic fluid, CVS)
- ●Inadequate sample volume or poor DNA quality
- ●Mosaic chromosomal abnormalities (may be missed if low-level)
- ●Recent blood transfusion (for blood samples) can cause false results
Compare With Similar Tests
| Test | FISH for Pre or Postnatal Diagnosis Chromosome 13 23 | FISH | Karyotyping |
|---|---|---|---|
| Comparison | FISH for Pre or Postnatal Diagnosis Chromosome 13 23 |
Frequently Asked Questions
What is FISH for Chromosome 13 and 23?
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What sample is needed?
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Are there any risks associated with the test?
Can this test detect all chromosomal abnormalities?
Do I need genetic counseling?
Is home sample collection available?
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