FISH for HER-2 Neu Test
Short Name: FISH HER2/ERBB2
Also known as: HER-2 FISH Test, ERBB2 Amplification Test, Fluorescence In Situ Hybridization for HER-2
FISH for HER-2 Neu Test test available at DNA Labs India for ₹14,000. Uses FISH on Formalin fixed paraffin embedded tissue block samples. Results in Reports are typically available within 10-12 days from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To determine the HER-2 gene amplification status in breast cancer cells for assessing eligibility for targeted therapy and guiding treatment planning.
- Test Code
- 582
- Price
- ₹14,000
- Sample Type
- Formalin fixed paraffin embedded tissue block
- Result Time
- Reports are typically available within 10-12 days from sample receipt.
- Fasting Required
- No
- Method
- FISH
Sample Collection
Ensure the tissue block is properly labeled and accompanied by the filled Chromosome & FISH analysis Requisition Form (Form 17). No specific patient preparation required.
Method: Biopsy or Surgery
Laboratory Analysis
Tissue is obtained via biopsy or surgery during medical procedures performed by healthcare professionals.
Report Delivery
Store tissue block at room temperature and ship promptly to the laboratory. Avoid freezing or improper storage conditions.
Timeline: Reports are typically available within 10-12 days from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To determine the HER-2 gene amplification status in breast cancer cells for assessing eligibility for targeted therapy and guiding treatment planning.
How to Prepare
- Submit a Formalin fixed paraffin embedded tissue block
- Ship at room temperature
- Tissue block must contain at least 10% tumor tissue
- Include duly filled Chromosome & FISH analysis Requisition Form (Form 17)
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The FISH test for HER-2 is crucial for determining eligibility for Herceptin therapy in breast cancer patients, enabling personalized treatment plans."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor tissue (<10%)
- Improper fixation or embedding
- Missing or incomplete requisition form
- Degraded or damaged tissue sample
Understanding Your Results
HER-2 gene amplification detected, suggesting eligibility for HER-2 targeted therapies like Herceptin.
Action: Consult oncologist for personalized treatment options.
Status: Positive (Amplified)
No HER-2 gene amplification detected, indicating alternative treatment approaches may be needed.
Action: Discuss other therapeutic strategies with healthcare provider.
Status: Negative (Non-amplified)
After receiving test results, promptly consult your oncologist to discuss the implications for treatment, especially if positive for HER-2 amplification.
Limitations
- ⚠Only applicable for invasive breast cancer components
- ⚠Requires sufficient tumor tissue (minimum 10%)
- ⚠Not a standalone diagnostic; should be correlated with clinical findings
- ⚠Results may vary based on laboratory expertise and equipment
Risks & Considerations
- ●Minimal risks associated with biopsy or surgery procedures, such as infection or bleeding, performed by healthcare providers.
Interfering Factors
- ●Tissue quality and fixation
- ●Insufficient tumor cell percentage (<10%)
- ●Improper sample handling or shipping
- ●Technical errors in FISH procedure
Compare With Similar Tests
| Test | FISH for HER-2 Neu | Immunohistochemistry (IHC) for HER-2 | Breast Cancer Gene Panel (e.g., BRCA1/2) |
|---|---|---|---|
| Comparison | FISH for HER-2 Neu | FISH is more accurate for detecting gene amplification, while IHC measures protein expression. FISH is often used to confirm equivocal IHC results. | Gene panels assess multiple genetic mutations, whereas FISH specifically targets HER-2 amplification for therapy guidance. |
Frequently Asked Questions
What is FISH for HER-2 Neu?
Why is this test important for breast cancer?
How is the test performed?
What does a positive result mean?
What does a negative result mean?
What is the cost of the FISH for HER-2 Neu test?
Is home sample collection available?
How long does it take to get results?
What sample is required for the test?
Are there any special instructions for sample collection?
Can this test be used for other cancers besides breast cancer?
Is the test covered by insurance?
Related Tests
B-Cell Rearrangement Detection Test
₹22,000Acute Lymphoblastic Leukemia (ALL) Cytogenetics Panel Test
₹20,000Epstein-Barr Virus Early RNA (EBER-ISH) In-Situ-Hybridization Test
₹6,000OncoPro NCCN Lung Cancer Panel with PD-L1 Test
₹140,400Acute Myeloid Leukemia (AML) Cytogenetics Panel Test
₹23,000AML ETO t(8;21) Gene Rearrangement PCR Qualitative Test
₹6,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.