FISH - Multiple Myeloma with Positive Selection of CD138 Cells Test
FISH - Multiple Myeloma with Positive Selection of CD138 Cells Test test available at DNA Labs India for ₹16,500. Uses FISH on Bone Marrow or Whole Blood samples. Results in 4 Working days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the FISH - Multiple Myeloma with Positive Selection of CD138 Cells Test is to detect specific genetic abnormalities in plasma cells, including: *Del 13q14.3, *del 17p13.1, *t(11;14) CCND1/IGH, *t(4;14) FGFR3/IGH, *t(14;16) IGH/MAF, and *Gain 1q. These abnormalities are associated with multiple myeloma and help in assessing prognosis and guiding targeted therapy.
- Test Code
- 584
- Price
- ₹16,500
- Sample Type
- Bone Marrow or Whole Blood
- Result Time
- 4 Working days
- Fasting Required
- No
- Method
- FISH
Sample Collection
Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. No specific fasting required.
Method: Bone Marrow Aspiration or Venipuncture
Laboratory Analysis
Sample collection via bone marrow aspiration or venipuncture. For bone marrow, a needle is inserted into the bone; for blood, a standard blood draw is performed.
Report Delivery
Ship sample at 18-22°C. Do not freeze. Ensure proper labeling and transport to the laboratory.
Timeline: 4 Working days
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the FISH - Multiple Myeloma with Positive Selection of CD138 Cells Test is to detect specific genetic abnormalities in plasma cells, including: *Del 13q14.3, *del 17p13.1, *t(11;14) CCND1/IGH, *t(4;14) FGFR3/IGH, *t(14;16) IGH/MAF, and *Gain 1q. These abnormalities are associated with multiple myeloma and help in assessing prognosis and guiding targeted therapy.
How to Prepare
- Collect 4 mL (2 mL min.) bone marrow in a green top (Sodium Heparin) tube or 5 mL (3 mL min.) whole blood
- Maintain sample at room temperature (18-22°C)
- Do not freeze the sample
- Complete the Chromosome & FISH analysis Requisition Form (Form 17) before collection
- Transport sample to the laboratory within 48 hours of collection
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is essential for identifying high-risk genetic abnormalities in multiple myeloma, which guide personalized treatment decisions and prognosis assessment."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample collected in incorrect tube type
- Sample frozen or stored improperly
- Insufficient sample volume
- Missing or incomplete requisition form
Understanding Your Results
del 13q14.3, t(4;14), t(14;16), del 17p
t(11;14)
Gain 1q
No abnormalities detected
Consult a healthcare professional if you experience symptoms of multiple myeloma, such as persistent bone pain, fatigue, weight loss, or frequent infections. Also, if test results show abnormalities, seek guidance from an oncologist for treatment options.
Limitations
- ⚠May not detect all genetic abnormalities in multiple myeloma
- ⚠Requires specialized laboratory equipment and expertise
- ⚠Sensitivity is higher than conventional cytogenetics but not absolute
- ⚠Cost may be prohibitive for some patients without insurance coverage
Risks & Considerations
- ●Pain or discomfort at the collection site
- ●Risk of infection or bleeding, especially with bone marrow aspiration
- ●Rarely, allergic reactions to anesthesia
Interfering Factors
- ●Poor sample quality or contamination
- ●Improper storage or handling of the sample
- ●Presence of non-viable cells
Compare With Similar Tests
| Test | FISH - Multiple Myeloma with Positive Selection of CD138 Cells Test | Conventional Cytogenetics | Bone Marrow Biopsy | Serum Protein Electrophoresis | Other FISH Panels |
|---|---|---|---|---|---|
| Comparison | FISH - Multiple Myeloma with Positive Selection of CD138 Cells Test |
Frequently Asked Questions
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