FISH - MYCN Amplification Test
Short Name: MYCN Amplification FISH
Also known as: Fluorescence In Situ Hybridization for MYCN Gene Amplification
FISH - MYCN Amplification Test test available at DNA Labs India for ₹12,000. Uses FISH on Formalin fixed paraffin embedded (FFPE) tissue block samples. Results in Results available within 4 working days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The FISH - MYCN Amplification Test is a laboratory test that is used to detect the amplification of the MYCN gene in neuroblastoma and other solid tumors. This amplification is associated with aggressive disease and poor outcome, and detection helps in stratifying patients for aggressive treatment.
- Test Code
- 587
- Price
- ₹12,000
- Sample Type
- Formalin fixed paraffin embedded (FFPE) tissue block
- Result Time
- Results available within 4 working days after sample receipt.
- Fasting Required
- No
- Method
- FISH
Sample Collection
A certified phlebotomist visits your home or you visit our nearest center. The process takes under 5 minutes.
Method: Biopsy sample
Laboratory Analysis
Your sample is analyzed using FISH in our laboratory.
Report Delivery
A certified pathologist reviews and signs your report. You receive it as a secure PDF via email and WhatsApp.
Timeline: Results available within 4 working days after sample receipt.
About This Test
Who Should Get This Test
The FISH - MYCN Amplification Test is a laboratory test that is used to detect the amplification of the MYCN gene in neuroblastoma and other solid tumors. This amplification is associated with aggressive disease and poor outcome, and detection helps in stratifying patients for aggressive treatment.
How to Prepare
- Submit formalin fixed paraffin embedded (FFPE) tissue block
- Ship at room temperature
- Ensure tissue block contains at least 10% tumor tissue
- Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
- Tissue block with less than 10% tumor content
- Incompletely filled or missing requisition form
- Improperly preserved sample
Understanding Your Results
Positive for MYCN amplification
Indicates aggressive disease, poor outcome, and likely need for intensive treatment.
Negative for MYCN amplification
Suggests lower risk; other factors should be considered for prognosis and therapy.
If a child exhibits symptoms such as abdominal swelling, chest pain, or unexplained weight loss, consult a doctor immediately for evaluation and possible diagnostic testing.
Limitations
- ⚠Limited to detection of MYCN gene amplification only
- ⚠Requires adequate tumor tissue (minimum 10%)
- ⚠False negatives possible due to tumor heterogeneity
Risks & Considerations
- ●Minimal risks from biopsy procedure, such as infection or bleeding
- ●No direct risks from the FISH test itself
Interfering Factors
- ●Poor sample fixation
- ●Insufficient tumor tissue in the sample
- ●Sample contamination
Frequently Asked Questions
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