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FISH - NTRK 2 Gene Rearrangement Assay Test

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FISH - NTRK 2 Gene Rearrangement Assay Test

Also known as: NTRK2 FISH Test, NTRK2 Rearrangement Assay

FISH - NTRK 2 Gene Rearrangement Assay Test test available at DNA Labs India for ₹7,020. Uses Fluorescence In Situ Hybridization (FISH) on Formalin fixed paraffin embedded tissue block or three 4 micron sections on Poly L Lysine coated slides. samples. Results in Report available in 4 working days.. Free home collection in 300+ cities across India.

Oncology🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect rearrangements in the NTRK2 gene associated with various cancers for diagnosis and treatment planning.

Test Code
589
Price
₹7,020
Sample Type
Formalin fixed paraffin embedded tissue block or three 4 micron sections on Poly L Lysine coated slides.
Result Time
Report available in 4 working days.
Fasting Required
No
Method
Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

Complete the Genomics Clinical Information Requisition Form (Form 20).

Method: Biopsy or tissue sample collection

Step 2

Laboratory Analysis

Sample collection via biopsy or surgical procedure.

Step 3

Report Delivery

Sample is processed and analyzed in the lab for FISH analysis.

Timeline: Report available in 4 working days.

Patient Instructions

1
Before the Test:Consult with your oncologist and complete necessary forms, including the Genomics Clinical Information Requisition Form (Form 20).
2
During the Test:Sample collection procedure, typically via biopsy or surgery, to obtain tissue for analysis.
3
After the Test:Wait for lab analysis and results, then follow up with your doctor for interpretation and next steps.

About This Test

Who Should Get This Test

To detect rearrangements in the NTRK2 gene associated with various cancers for diagnosis and treatment planning.

How to Prepare

  • Submit formalin fixed paraffin embedded tissue block or three 4 micron sections on Poly L Lysine coated slides.
  • Ship at room temperature.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This test is crucial for identifying patients who may benefit from targeted therapy with NTRK inhibitors like Larotrectinib or Entrectinib, which have shown high response rates in various cancers."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeFormalin fixed paraffin embedded tissue block or three 4 micron sections on Poly L Lysine coated slides.
ContainerTissue block or slides
Collection MethodBiopsy or tissue sample collection

Sample Stability

Room temperature: Stable for shipping
Refrigerator: Not required
Frozen: Not recommended
Sample Rejection Criteria:
  • Improper sample type
  • Damaged slides
  • Missing requisition form

Understanding Your Results

Results indicate the presence or absence of NTRK2 gene rearrangements, which guide treatment decisions for cancer patients.
📊

Positive

NTRK2 gene rearrangement detected, indicating potential for targeted therapy with NTRK inhibitors like Larotrectinib or Entrectinib.

📊

Negative

No NTRK2 gene rearrangement detected. Further evaluation may be needed based on clinical symptoms.

⚠️ When to Consult a Doctor:

If symptoms such as abnormal growths or neurological issues persist, or if recommended by your oncologist for cancer diagnosis.

Limitations

  • ⚠Limited to detection of rearrangements, not point mutations
  • ⚠Requires high-quality tissue samples

Risks & Considerations

  • ●Minimal risks associated with sample collection, such as infection or bleeding
  • ●Potential for false positives or negatives in rare cases

Interfering Factors

  • ●Poor sample preservation
  • ●Inadequate tissue quantity
  • ●Contamination

Frequently Asked Questions

What is the FISH - NTRK 2 Gene Rearrangement Assay Test?
It is a genetic test that uses fluorescence in situ hybridization (FISH) to detect rearrangements in the NTRK2 gene, which can be associated with various cancers.
What is the NTRK2 gene and its function?
The NTRK2 gene produces the TrkB protein, involved in nervous system development and function. Alterations can lead to cancer.
What symptoms indicate the need for this test?
Symptoms include abnormal growths or tumors, neurological issues, developmental delays, or other signs of cancer linked to NTRK2 gene changes.
How is the test performed?
The test is performed on a tissue sample using FISH technology. Fluorescent probes bind to specific parts of the gene to detect rearrangements under a microscope.
What sample type is required?
Submit formalin fixed paraffin embedded tissue block or three 4 micron sections on Poly L Lysine coated slides, shipped at room temperature.
What is the cost of the test?
The cost is INR 7020.0 at DNA Labs India, with free home sample collection available.
How long does it take to get results?
Reports are typically available within 4 working days after sample receipt.
Is home sample collection available?
Yes, DNA Labs India offers free home collection for online bookings across India.
What cancers are associated with NTRK2 rearrangements?
Associated cancers include glioblastomas, pilocytic astrocytomas, head and neck squamous cell carcinoma, and lung adenocarcinoma.
What treatment options are available if the test is positive?
Positive results may indicate eligibility for targeted therapy with NTRK inhibitors like Larotrectinib or Entrectinib, which have high response rates.
Is the test covered by insurance?
Coverage depends on your insurance plan. Contact your provider or DNA Labs India for details.
Who should I consult for this test?
Consult your oncologist or a specialist in clinical genetics for referral and interpretation of results.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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