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FISH - NTRK 3 Gene Rearrangement Assay Test

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FISH - NTRK 3 Gene Rearrangement Assay Test

Short Name: NTRK3 FISH Test

Also known as: NTRK3 Gene Rearrangement FISH, FISH Assay for NTRK3 Rearrangements

FISH - NTRK 3 Gene Rearrangement Assay Test test available at DNA Labs India for ₹7,020. Uses FISH on Formalin-fixed paraffin-embedded tissue block or three 4-micron sections on Poly-L-Lysine coated slides samples. Results in 4 Working Days. Free home collection in 300+ cities across India.

DiagnosticAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect NTRK3 gene rearrangements in cancer patients to guide targeted therapy decisions and improve treatment efficacy.

Test Code
591
Price
₹7,020
Sample Type
Formalin-fixed paraffin-embedded tissue block or three 4-micron sections on Poly-L-Lysine coated slides
Result Time
4 Working Days
Fasting Required
No
Method
FISH
Step 1

Sample Collection

Ensure the Genomics Clinical Information Requisition Form (Form 20) is duly filled and accompany the sample.

Method: Tissue Biopsy

Step 2

Laboratory Analysis

Standard tissue biopsy procedure; collect formalin-fixed paraffin-embedded tissue block or sections as specified.

Step 3

Report Delivery

Label the sample correctly and transport at room temperature to the lab promptly.

Timeline: 4 Working Days

Patient Instructions

1
Before the Test:No specific preparation is required, but ensure the requisition form is completed and the sample is properly collected.
2
During the Test:The sample is processed in the lab using FISH technology to visualize NTRK3 gene rearrangements.
3
After the Test:The report will be available within 4 working days and can be accessed online or via email/WhatsApp.

About This Test

Who Should Get This Test

The purpose of this test is to detect NTRK3 gene rearrangements in cancer patients to guide targeted therapy decisions and improve treatment efficacy.

How to Prepare

  • Submit formalin-fixed paraffin-embedded tissue block or three 4-micron sections on Poly-L-Lysine coated slides
  • Ship at room temperature
  • Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"NTRK3 rearrangements are targetable mutations in various cancers. FISH testing is crucial for identifying patients who may benefit from NTRK inhibitors like Larotrectinib or Entrectinib, leading to high response rates."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeFormalin-fixed paraffin-embedded tissue block or three 4-micron sections on Poly-L-Lysine coated slides
ContainerTissue Block or Slides
Collection MethodTissue Biopsy

Sample Stability

Room temperature: Stable for shipping
Refrigerator: Not recommended
Frozen: Not applicable
Sample Rejection Criteria:
  • Insufficient sample volume
  • Degraded or improperly fixed tissue
  • Missing requisition form

Understanding Your Results

The test result indicates whether NTRK3 gene rearrangements are present, which can influence cancer treatment strategies.
📊

Positive

NTRK3 gene rearrangement detected; patient may be eligible for NTRK inhibitor therapy such as Larotrectinib or Entrectinib.

📊

Negative

No NTRK3 gene rearrangement detected; standard cancer treatments should be considered based on other factors.

⚠️ When to Consult a Doctor:

Consult your doctor if you have symptoms of cancer (e.g., unexplained weight loss, persistent pain), a family history of cancer, or if you are diagnosed with a cancer type associated with NTRK3 rearrangements.

Limitations

  • ⚠May not detect all types of NTRK3 rearrangements
  • ⚠Requires adequate tissue sample quality
  • ⚠Results are qualitative and may need confirmation with other methods

Risks & Considerations

  • ●Minimal risks associated with tissue biopsy procedure, such as infection or bleeding at the biopsy site

Interfering Factors

  • ●Tissue degradation
  • ●Inadequate sample fixation
  • ●Contamination during collection

Compare With Similar Tests

TestFISH - NTRK 3 Gene Rearrangement Assay TestNGS Panel for NTRK FusionsPCR-based Assays
ComparisonFISH - NTRK 3 Gene Rearrangement Assay Test

Frequently Asked Questions

What is the FISH NTRK3 Gene Rearrangement Assay Test?
It is a genetic test using Fluorescence In Situ Hybridization (FISH) to detect NTRK3 gene rearrangements in cancer tissues, helping guide targeted therapy.
Who should consider taking this test?
Patients diagnosed with cancers like lung cancer, colorectal cancer, glioblastomas, or secretory breast carcinoma, especially if standard treatments are ineffective.
How is the sample collected for this test?
A tissue biopsy is performed to obtain a formalin-fixed paraffin-embedded tissue block or sections, which are then sent to the lab.
What does a positive result mean?
A positive result indicates the presence of NTRK3 gene rearrangements, suggesting eligibility for NTRK inhibitor therapies such as Larotrectinib or Entrectinib.
What does a negative result mean?
A negative result means no NTRK3 rearrangements were detected; other treatment options should be discussed with your doctor.
Is fasting required before this test?
No, fasting is not required as the test is performed on tissue samples.
How long does it take to get the results?
Results are typically available within 4 working days after sample receipt.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across many cities in India for online bookings.
What is the cost of this test?
The test costs INR 7020, with discounts available for online bookings.
Are there any risks associated with this test?
The test itself has no direct risks, but the biopsy procedure may involve minor risks like infection or bleeding.
Can this test be used for other cancers?
Yes, it can be used for various cancers linked to NTRK3 rearrangements, including glioblastomas and leukemia.
How should I prepare for sample collection?
Ensure the Genomics Clinical Information Requisition Form (Form 20) is filled out and accompany the sample during collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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