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FISH - PDGFR Alpha (4q12) Gene Rearrangement Test

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FISH - PDGFR Alpha (4q12) Gene Rearrangement Test

Short Name: FISH PDGFR Alpha Test

Also known as: FIP1L1-PDGFRA Rearrangement Test, PDGFR Alpha FISH Test

FISH - PDGFR Alpha (4q12) Gene Rearrangement Test test available at DNA Labs India for ₹6,000. Uses FISH on Whole Blood or Bone Marrow samples. Results in 4 Working Days. Free home collection in 300+ cities across India.

DiagnosticAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect PDGFR alpha gene rearrangements for the diagnosis and management of associated cancers like chronic eosinophilic leukemia.

Test Code
593
Price
₹6,000
Sample Type
Whole Blood or Bone Marrow
Result Time
4 Working Days
Fasting Required
No
Method
FISH
Step 1

Sample Collection

Complete the Chromosome & FISH analysis Requisition Form (Form 17).

Method: Venipuncture for blood, Bone Marrow Aspiration for bone marrow

Step 2

Laboratory Analysis

Sample will be collected via venipuncture or bone marrow aspiration by a trained professional.

Step 3

Report Delivery

Apply pressure to the site to prevent bleeding. Follow standard post-procedure care.

Timeline: 4 Working Days

Patient Instructions

1
Before the Test:Ensure requisition form is completed. No fasting required.
2
During the Test:Sample collection takes about 15-30 minutes.
3
After the Test:Results will be available in 4 working days.

About This Test

Who Should Get This Test

To detect PDGFR alpha gene rearrangements for the diagnosis and management of associated cancers like chronic eosinophilic leukemia.

How to Prepare

  • Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
  • Sample: 5 mL whole blood or 4 mL bone marrow in sodium heparin tubes.
  • Ship at 18-22°C. Do not freeze.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This FISH test is essential for diagnosing PDGFR alpha rearrangements, which guide treatment decisions in certain leukemias."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood or Bone Marrow
Sample Volume5 mL (3 mL min.) whole blood OR 4 mL (2 mL min.) Bone Marrow
Container2 Green Top (Sodium Heparin) tubes
Collection MethodVenipuncture for blood, Bone Marrow Aspiration for bone marrow

Sample Stability

Room Temperature
Refrigerated
Frozen
Sample Rejection Criteria:
  • Incorrect sample type
  • Insufficient volume
  • Clotted sample
  • Missing requisition form

Understanding Your Results

Results indicate the presence or absence of PDGFR alpha gene rearrangements via FISH analysis.
📊

Positive

PDGFR alpha rearrangement detected. Associated with chronic eosinophilic leukemia or other myeloid neoplasms. Further testing and consultation with an oncologist recommended.

📊

Negative

No PDGFR alpha rearrangement detected. Clinical correlation advised if symptoms persist.

⚠️ When to Consult a Doctor:

If symptoms like unexplained weight loss, fatigue, or lumps persist, or if you have a family history of leukemia.

Limitations

  • ⚠Cannot detect all genetic variations
  • ⚠Requires fresh or appropriately preserved samples
  • ⚠False negatives possible in low cellularity samples

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare infection
  • ●Discomfort during bone marrow aspiration

Interfering Factors

  • ●Sample contamination
  • ●Inadequate sample volume
  • ●Poor cell viability

Compare With Similar Tests

TestFISH - PDGFR Alpha (4q12) Gene Rearrangement TestFISH - BCR-ABLPCR for PDGFR AlphaBone Marrow Biopsy
ComparisonFISH - PDGFR Alpha (4q12) Gene Rearrangement TestDetects BCR-ABL fusion for chronic myeloid leukemia, while PDGFR alpha is for chronic eosinophilic leukemia.PCR may be more sensitive for specific mutations, but FISH is standard for detecting rearrangements.Provides morphological assessment, complementary to genetic testing.

Frequently Asked Questions

What is the FISH - PDGFR Alpha (4q12) Gene Rearrangement Test?
It is a genetic test that uses Fluorescent In Situ Hybridization (FISH) to detect rearrangements in the PDGFR alpha gene, associated with cancers like chronic eosinophilic leukemia.
Why is this test performed?
To diagnose PDGFR alpha rearrangements in patients with suspected leukemia or related symptoms, guiding treatment decisions.
What sample is required for the test?
5 mL whole blood or 4 mL bone marrow in sodium heparin tubes.
How long does it take to get results?
Results are typically available within 4 working days.
What does a positive result mean?
A positive result indicates PDGFR alpha rearrangement is detected, associated with certain leukemias. Further evaluation by an oncologist is recommended.
What does a negative result mean?
A negative result means no rearrangement was detected. Clinical correlation is advised if symptoms persist.
Is the test covered by insurance?
Coverage varies; it may not be covered by all insurance plans. Consult your provider for details.
Are there any risks associated with the test?
Risks are minimal and include bruising, rare infection, or discomfort during sample collection.
How should I prepare for the test?
Complete the mandatory requisition form (Form 17). No fasting is required.
Can the test detect all types of leukemia?
It specifically detects PDGFR alpha rearrangements, which are linked to chronic eosinophilic leukemia and some other leukemias, but not all types.
What is the cost of the test?
The cost at DNA Labs India is INR 6000, inclusive of analysis and interpretation.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across numerous cities in India.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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