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DNA Labs India

FISH - RET Gene (10q11.2) Rearrangement Test

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FISH - RET Gene (10q11.2) Rearrangement Test

Short Name: RET FISH Test

Also known as: RET Gene Rearrangement Analysis, RET FISH Test

FISH - RET Gene (10q11.2) Rearrangement Test test available at DNA Labs India for ₹10,500. Uses FISH on Formalin fixed paraffin embedded tissue block samples. Results in 4 Working days. Free home collection in 300+ cities across India.

Molecular DiagnosticAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of the FISH - RET Gene Rearrangement Test is to detect rearrangements in the RET gene, which are implicated in the development of certain cancers like thyroid and lung cancer. This test aids in accurate diagnosis, classification of cancer types, and informs the use of targeted therapies to improve patient outcomes.

Test Code
599
Price
₹10,500
Sample Type
Formalin fixed paraffin embedded tissue block
Result Time
4 Working days
Fasting Required
No
Method
FISH
Step 1

Sample Collection

Ensure a duly filled Chromosome & FISH analysis Requisition Form (Form 17) is provided. No specific patient preparation is required.

Method: Tissue biopsy collection

Step 2

Laboratory Analysis

Tissue biopsy is collected from the suspected tumor site by a healthcare professional.

Step 3

Report Delivery

The tissue block is shipped to the lab at room temperature for processing.

Timeline: 4 Working days

Patient Instructions

1
Before the Test:Ensure the requisition form is completed and the tissue sample is collected as per instructions.
2
During the Test:The FISH procedure involves labeling DNA probes to detect RET gene rearrangements under a microscope.
3
After the Test:Results are analyzed and reported within the turnaround time.

About This Test

Who Should Get This Test

The purpose of the FISH - RET Gene Rearrangement Test is to detect rearrangements in the RET gene, which are implicated in the development of certain cancers like thyroid and lung cancer. This test aids in accurate diagnosis, classification of cancer types, and informs the use of targeted therapies to improve patient outcomes.

How to Prepare

  • Submit Formalin fixed paraffin embedded tissue block.
  • Ship at room temperature.
  • Tissue block must contain at least 10% tumor tissue.
  • Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"RET gene rearrangements are critical for diagnosing certain cancers and predicting response to targeted therapies. Early detection through FISH testing can guide personalized treatment plans."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeFormalin fixed paraffin embedded tissue block
ContainerFormalin fixed paraffin embedded tissue block
Collection MethodTissue biopsy collection
Sample Rejection Criteria:
  • Tissue block with less than 10% tumor tissue may be rejected.
  • Inadequate or improperly preserved samples.

Understanding Your Results

Results indicate whether RET gene rearrangements are present, which can guide cancer diagnosis and treatment strategies.
📊

Positive for RET rearrangement

Detection of RET gene rearrangement suggests association with cancers like thyroid or lung cancer. This may indicate eligibility for targeted therapies and warrants further clinical evaluation.

📊

Negative for RET rearrangement

No RET gene rearrangement detected. Clinical correlation with other diagnostic findings is recommended.

⚠️ When to Consult a Doctor:

If you experience symptoms such as thyroid nodules, persistent cough, or difficulty breathing, or if diagnosed with cancer, consult an oncologist or healthcare professional for evaluation and potential testing.

Limitations

  • ⚠Test is specific to RET gene rearrangements and may not detect other genetic alterations.
  • ⚠Requires adequate tumor tissue in the sample for accurate results.

Risks & Considerations

  • ●Minimal risks associated with tissue biopsy collection, such as infection or bleeding at the biopsy site.
  • ●No direct risks from the FISH test itself.

Frequently Asked Questions

What is the FISH - RET Gene Rearrangement Test?
It is a diagnostic test using Fluorescence In Situ Hybridization to detect rearrangements in the RET gene, which are associated with cancers like thyroid and lung cancer.
Why is this test recommended?
It is recommended for diagnosing RET gene rearrangements in patients with symptoms or history of thyroid or lung cancer, aiding in treatment planning.
What are the symptoms of RET gene rearrangement?
Symptoms may include thyroid nodules, hoarseness, difficulty breathing or swallowing, persistent cough, and chest pain.
How is the test performed?
The test involves analyzing a formalin-fixed paraffin-embedded tissue block using FISH technology to identify RET gene rearrangements.
What sample is required for the test?
A tissue block containing at least 10% tumor tissue is required, shipped at room temperature with a completed requisition form.
Is fasting required before the test?
No, fasting is not required for this test.
What is the cost of the test?
The cost at DNA Labs India is INR 10500, with home sample collection available across India.
How long does it take to get the results?
Results are typically available within 4 working days after sample receipt.
What does a positive result mean?
A positive result indicates the presence of RET gene rearrangement, which may be associated with certain cancers and guide targeted therapy options.
Are there any risks associated with the test?
Risks are minimal and mainly related to the tissue biopsy procedure, such as infection or bleeding. The FISH test itself is non-invasive.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across numerous cities in India.
How should I prepare for the test?
Ensure the requisition form is duly filled, and the tissue sample is collected and shipped as per instructions. No special preparation is needed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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