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DNA Labs India

FISH - ROS1 (6q22) Rearrangement Test

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FISH - ROS1 (6q22) Rearrangement Test

Short Name: ROS1 FISH Test

Also known as: ROS1 Rearrangement FISH Test, FISH for ROS1 Gene, ROS1 FISH Analysis

FISH - ROS1 (6q22) Rearrangement Test test available at DNA Labs India for ₹8,500. Uses Fluorescence in situ hybridization (FISH) on Formalin fixed paraffin embedded tissue block samples. Results in 4 Working days. Free home collection in 300+ cities across India.

Diagnostic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To detect rearrangements in the ROS1 gene on chromosome 6q22 in tumor samples, aiding in the diagnosis and management of non-small cell lung cancer, and guiding targeted therapy decisions.

Test Code
607
Price
₹8,500
Sample Type
Formalin fixed paraffin embedded tissue block
Result Time
4 Working days
Fasting Required
No
Method
Fluorescence in situ hybridization (FISH)
Step 1

Sample Collection

Ensure the tissue block is properly labeled and accompanied by a filled Chromosome & FISH analysis Requisition Form (Form 17).

Method: Tissue biopsy collection

Step 2

Laboratory Analysis

Collection is performed during biopsy or surgery. No special procedure for the test itself.

Step 3

Report Delivery

Transport the FFPE tissue block at room temperature to the laboratory.

Timeline: 4 Working days

Patient Instructions

1
Before the Test:No specific preparation required. Ensure tissue sample is available and form is submitted.
2
During the Test:The test is performed in the laboratory using FISH technology. No patient involvement during the test.
3
After the Test:Results are reported to the referring physician. Follow-up based on results.

About This Test

Who Should Get This Test

To detect rearrangements in the ROS1 gene on chromosome 6q22 in tumor samples, aiding in the diagnosis and management of non-small cell lung cancer, and guiding targeted therapy decisions.

How to Prepare

  • Submit formalin-fixed paraffin-embedded tissue block
  • Ensure tissue block contains at least 10% tumor tissue
  • Complete and attach Form 17 (Chromosome & FISH analysis Requisition Form)
  • Ship at room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"The FISH - ROS1 test is essential for identifying patients with ROS1-rearranged lung cancer, enabling personalized treatment with targeted therapies like crizotinib, which can significantly improve outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeFormalin fixed paraffin embedded tissue block
Sample VolumeNot specified
ContainerFFPE tissue block
Collection MethodTissue biopsy collection

Sample Stability

Store at room temperature
Stable for extended periods when fixed in FFPE
Sample Rejection Criteria:
  • Insufficient tumor tissue (<10%)
  • Missing or incomplete Form 17
  • Improperly fixed or degraded tissue

Understanding Your Results

Results indicate whether ROS1 gene rearrangement is present or absent in the tumor sample.
📊

Positive

ROS1 gene rearrangement detected. Patient may be eligible for targeted therapy with ROS1 inhibitors.

📊

Negative

No ROS1 gene rearrangement detected. Consider other molecular testing or therapies.

📊

Inconclusive

Test could not determine rearrangement. Repeat test or use alternative methods.

⚠️ When to Consult a Doctor:

If you have symptoms of lung cancer such as persistent cough, chest pain, or weight loss, consult an oncologist. After test results, discuss with your doctor for treatment options.

Limitations

  • ⚠May not detect all variants of ROS1 rearrangements
  • ⚠Requires adequate tumor sample
  • ⚠Not suitable for liquid biopsy

Risks & Considerations

  • ●Minimal risk as it involves existing tissue sample
  • ●Standard biopsy risks if applicable

Interfering Factors

  • ●Poor tissue quality
  • ●Insufficient tumor content
  • ●Improper fixation of tissue

Compare With Similar Tests

TestFISH - ROS1 (6q22) Rearrangement TestALK Rearrangement TestEGFR Mutation TestKRAS Mutation TestPD-L1 Expression Test
ComparisonFISH - ROS1 (6q22) Rearrangement TestSimilar FISH-based test for ALK gene in lung cancer.Molecular test for EGFR mutations, often done in parallel.Detects KRAS mutations, another common target in NSCLC.Assesses PD-L1 for immunotherapy eligibility.

Frequently Asked Questions

What is the FISH - ROS1 (6q22) Rearrangement Test?
This test detects rearrangements in the ROS1 gene using fluorescence in situ hybridization (FISH) to diagnose lung cancer and guide targeted therapy.
Why is the FISH ROS1 test performed?
It is performed to identify ROS1 gene rearrangements in lung cancer patients, which can indicate eligibility for targeted treatments like crizotinib.
How much does the FISH ROS1 test cost at DNA Labs India?
The test costs INR 8500, with home sample collection available in many cities across India.
What sample is required for the test?
A formalin-fixed paraffin-embedded (FFPE) tissue block with at least 10% tumor content is required.
How is the FISH ROS1 test performed?
The test uses fluorescent probes to bind to the ROS1 gene in tumor cells, and rearrangements are visualized under a microscope.
What does a positive FISH ROS1 result mean?
A positive result indicates ROS1 gene rearrangement, suggesting the patient may benefit from ROS1 inhibitor therapies.
What does a negative FISH ROS1 result mean?
A negative result means no ROS1 rearrangement was detected, and other molecular tests or treatments may be considered.
Is home collection available for the FISH ROS1 test?
Yes, DNA Labs India offers free home sample collection for online bookings in many cities across India.
How long does it take to get FISH ROS1 test results?
Results are typically available within 4 working days after sample receipt.
Is the FISH ROS1 test painful?
The test itself is not painful as it involves analysis of an existing tissue sample collected during biopsy or surgery.
Are there any risks associated with the FISH ROS1 test?
The test poses minimal risk since it uses an existing tissue sample. Risks are primarily from the biopsy procedure if applicable.
Who should get the FISH ROS1 test?
Patients with non-small cell lung cancer, especially adenocarcinoma, or those suspected of having ROS1 rearrangements should consider this test.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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