FISH - Sperm Aneuploidy Test
Short Name: Sperm Aneuploidy FISH Test
Also known as: Fluorescence In Situ Hybridization - Sperm Aneuploidy Test, FISH for Sperm Chromosomal Abnormalities
FISH - Sperm Aneuploidy Test test available at DNA Labs India for ₹10,000. Uses Fluorescence In Situ Hybridization (FISH) on Semen samples. Results in Report available in 4 days from sample submission.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the FISH - Sperm Aneuploidy Test is to detect aneuploidy in sperm cells for chromosomes 13, 18, 21, and sex chromosomes (X and Y), helping to diagnose genetic causes of male infertility or recurrent pregnancy loss.
- Test Code
- 600
- Price
- ₹10,000
- Sample Type
- Semen
- Result Time
- Report available in 4 days from sample submission.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
Prior to sample collection, ensure a duly filled Chromosome & FISH analysis Requisition Form (Form 17) is prepared. Abstain from ejaculation for 2-5 days to optimize sperm quality. Avoid alcohol, caffeine, and tobacco for at least 48 hours before collection.
Method: Semen collection
Laboratory Analysis
The sample is collected via masturbation into a sterile, screw-capped container provided by the lab. Maintain hygiene to prevent contamination. The container should be labeled correctly and kept at room temperature.
Report Delivery
After collection, seal the container securely and transport it to the lab at room temperature as per instructions. Avoid exposing the sample to extreme temperatures. Results will be processed and delivered within 4 days.
Timeline: Report available in 4 days from sample submission.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the FISH - Sperm Aneuploidy Test is to detect aneuploidy in sperm cells for chromosomes 13, 18, 21, and sex chromosomes (X and Y), helping to diagnose genetic causes of male infertility or recurrent pregnancy loss.
How to Prepare
- Abstain from ejaculation for 2-5 days before sample collection.
- Collect semen sample via masturbation into a sterile, screw-capped container.
- Ensure the container is labeled with patient details and date.
- Submit the sample with a duly filled Chromosome & FISH analysis Requisition Form (Form 17).
- Transport the sample at room temperature to the laboratory.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for couples facing recurrent miscarriages or infertility to identify chromosomal issues in sperm, guiding treatment options like IVF with genetic screening."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Improper sample container or leakage
- Missing or incomplete requisition form
- Sample stored incorrectly (e.g., refrigerated or frozen)
- Insufficient sample volume
- Contaminated or hemolyzed sample
Understanding Your Results
Normal (<1% aneuploidy for each chromosome)
Low risk of chromosomal abnormalities in sperm; genetic factors may not be the primary cause of infertility.
Mildly elevated (1-5% aneuploidy)
Possible increased risk; consider genetic counseling and further fertility evaluation.
Moderately to severely elevated (>5% aneuploidy)
Significant chromosomal issues; high risk of infertility or recurrent miscarriage; consult a fertility specialist for advanced options like PGD/PGS.
Consult a fertility specialist or geneticist if test results show elevated aneuploidy levels, if you have ongoing infertility despite normal results, or if you have questions about implications for assisted reproduction.
Limitations
- ⚠Detects only numerical abnormalities (aneuploidy), not structural chromosomal defects
- ⚠Limited to specific chromosomes (13, 18, 21, X, Y); does not screen all chromosomes
- ⚠Results may not predict absolute fertility outcomes
- ⚠Requires skilled laboratory personnel for accurate interpretation
- ⚠Cannot diagnose genetic disorders in offspring directly
Risks & Considerations
- ●No significant physical risks as it involves semen collection only
- ●Possible mild discomfort during sample collection
- ●Emotional stress from results
Interfering Factors
- ●Poor sample quality or contamination
- ●Incorrect sample storage or handling
- ●Recent illness or fever affecting sperm production
- ●Use of certain medications that may alter sperm chromosomes
- ●Technical errors in FISH probe application or analysis
Compare With Similar Tests
| Test | FISH - Sperm Aneuploidy Test | Standard Semen Analysis | Karyotyping | Preimplantation Genetic Testing (PGT) |
|---|---|---|---|---|
| Comparison | FISH - Sperm Aneuploidy Test |
Frequently Asked Questions
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