FISH - t(12;21) or LSI TEL/AML1 Test
Short Name: FISH TEL/AML1 Test
Also known as: LSI TEL/AML1 Test, t(12;21) FISH Test, TEL-AML1 Fusion Test
FISH - t(12;21) or LSI TEL/AML1 Test test available at DNA Labs India for ₹6,000. Uses Fluorescence In Situ Hybridization (FISH) on Whole Blood or Bone Marrow samples. Results in 4 Working days from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the FISH - t(12;21) or LSI TEL/AML1 Test is to identify the presence of the TEL/AML1 fusion gene, which is associated with Acute Lymphoblastic Leukemia (ALL). This information helps in diagnosing ALL, determining its subtype, assessing prognosis, and guiding treatment decisions. It is particularly valuable in pediatric cases where this rearrangement is common.
- Test Code
- 605
- Price
- ₹6,000
- Sample Type
- Whole Blood or Bone Marrow
- Result Time
- 4 Working days from sample receipt
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation is required, but ensure the Chromosome & FISH analysis Requisition Form (Form 17) is duly filled and accompanies the sample.
Method: Venipuncture for blood; Bone Marrow Aspiration for marrow
Laboratory Analysis
Sample is collected via venipuncture for blood or bone marrow aspiration. The procedure is performed by a trained phlebotomist or healthcare professional.
Report Delivery
Apply pressure to the collection site to prevent bruising. Follow any post-procedure instructions provided by the healthcare provider.
Timeline: 4 Working days from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the FISH - t(12;21) or LSI TEL/AML1 Test is to identify the presence of the TEL/AML1 fusion gene, which is associated with Acute Lymphoblastic Leukemia (ALL). This information helps in diagnosing ALL, determining its subtype, assessing prognosis, and guiding treatment decisions. It is particularly valuable in pediatric cases where this rearrangement is common.
How to Prepare
- Ship samples at 18-22°C
- DO NOT FREEZE the samples
- Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
- Use 2 Green Top (Sodium Heparin) tubes for sample collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"The FISH TEL/AML1 test is essential for identifying the t(12;21) translocation in Acute Lymphoblastic Leukemia, which helps in prognosis and tailoring treatment strategies for better patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Clotted sample
- Insufficient sample volume
- Missing or incomplete requisition form
- Improper sample storage or shipping conditions
Understanding Your Results
Positive
Presence of TEL/AML1 fusion signals indicates the t(12;21) translocation, which is associated with a subtype of B-cell ALL with generally favorable prognosis.
Negative
No TEL/AML1 fusion signals detected. This does not rule out ALL; further testing such as karyotyping or PCR may be recommended.
Consult your doctor immediately if you experience symptoms of ALL such as persistent fever, fatigue, bone pain, easy bruising, or bleeding. Also, consult for interpretation of test results and to discuss treatment options.
Limitations
- ⚠FISH may not detect cryptic or variant rearrangements
- ⚠False negatives possible with low cellularity or sample quality
- ⚠Requires specific probes and experienced personnel for interpretation
Risks & Considerations
- ●Minor bruising or pain at the blood draw site
- ●Soreness or infection risk at bone marrow aspiration site (if applicable)
- ●No significant risks from the FISH procedure itself
Interfering Factors
- ●Sample contamination
- ●Degraded DNA or RNA
- ●Improper fixation of cells
- ●Technical errors during FISH procedure
Compare With Similar Tests
| Test | FISH - t(12;21) or LSI TEL/AML1 Test | Karyotyping | PCR for ALL Markers | Immunophenotyping |
|---|---|---|---|---|
| Comparison | FISH - t(12;21) or LSI TEL/AML1 Test |
Frequently Asked Questions
What is the FISH - t(12;21) or LSI TEL/AML1 Test?
Why is this test performed?
What samples are required for the test?
How is the test procedure done?
What is the cost of the FISH TEL/AML1 Test?
Is home collection available for this test?
How long does it take to receive the test results?
What does a positive test result indicate?
What should I do if my test result is negative?
Are there any risks or side effects from the test?
How accurate is the FISH test for detecting t(12;21)?
Can this test be used to monitor treatment response in ALL?
Related Tests
B-Cell Rearrangement Detection Test
₹22,000Acute Lymphoblastic Leukemia (ALL) Cytogenetics Panel Test
₹20,000Epstein-Barr Virus Early RNA (EBER-ISH) In-Situ-Hybridization Test
₹6,000OncoPro NCCN Lung Cancer Panel with PD-L1 Test
₹140,400Acute Myeloid Leukemia (AML) Cytogenetics Panel Test
₹23,000AML ETO t(8;21) Gene Rearrangement PCR Qualitative Test
₹6,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.