FISH - t(8;14) or MYC/IGH for Burkitt & Non-Hodgkin Lymphoma Test
Short Name: FISH t(8;14) MYC/IGH
Also known as: FISH t(8;14) test, MYC/IGH rearrangement test, Burkitt lymphoma FISH test
FISH - t(8;14) or MYC/IGH for Burkitt & Non-Hodgkin Lymphoma Test test available at DNA Labs India for ₹6,000. Uses Fluorescence In Situ Hybridization (FISH) on Whole Blood or Bone Marrow samples. Results in Reports available within 4 working days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The FISH t(8;14) or MYC/IGH test is done to confirm the diagnosis of Burkitt and Non-Hodgkin Lymphoma by detecting specific genetic rearrangements. It helps monitor disease progression, evaluate treatment effectiveness, and assess genetic risk in high-risk patients, aiding in personalized treatment planning.
- Test Code
- 608
- Price
- ₹6,000
- Sample Type
- Whole Blood or Bone Marrow
- Result Time
- Reports available within 4 working days after sample receipt.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. Ensure patient consent and proper identification.
Method: Venipuncture for blood, aspiration for bone marrow
Laboratory Analysis
For blood: collect via venipuncture into green top tubes. For bone marrow: aspiration from posterior iliac crest. Label samples correctly.
Report Delivery
Ship samples at 18-22°C. Do not freeze. Ensure transport to lab within stability time.
Timeline: Reports available within 4 working days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The FISH t(8;14) or MYC/IGH test is done to confirm the diagnosis of Burkitt and Non-Hodgkin Lymphoma by detecting specific genetic rearrangements. It helps monitor disease progression, evaluate treatment effectiveness, and assess genetic risk in high-risk patients, aiding in personalized treatment planning.
How to Prepare
- Use 2 Green Top (Sodium Heparin) tubes
- Ship at 18-22°C, do not freeze
- Fill out Form 17 completely
- For bone marrow, use aseptic technique
- Maintain sample integrity during transport
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This FISH test is essential for confirming Burkitt lymphoma diagnosis and tailoring treatment, improving patient outcomes significantly."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample in incorrect container (not green top)
- Hemolyzed or clotted sample
- Insufficient volume
- Missing or incomplete Form 17
- Sample not shipped at specified temperature
Understanding Your Results
Positive (rearrangement detected)
Indicates presence of t(8;14) or MYC/IGH translocation, strongly suggestive of Burkitt Lymphoma or certain Non-Hodgkin Lymphomas. Consult oncologist for treatment.
Action: Immediate medical consultation for diagnosis confirmation and treatment planning.
Negative (no rearrangement detected)
No evidence of t(8;14) or MYC/IGH translocation. Does not rule out lymphoma; correlation with other tests recommended.
Action: Discuss with physician for additional diagnostics if symptoms persist.
Consult a doctor if you experience symptoms like swollen lymph nodes, unexplained weight loss, or night sweats, or if test results are positive or inconclusive.
Limitations
- ⚠May not detect all genetic abnormalities related to lymphoma
- ⚠False negatives possible if translocation is atypical
- ⚠Results should be correlated with clinical and histopathological findings
- ⚠Limited to detecting t(8;14) and related rearrangements
Risks & Considerations
- ●For blood collection: minor pain, bruising, or infection at puncture site
- ●For bone marrow biopsy: pain, bleeding, or rarely infection
- ●Minimal risk from FISH testing itself as it's a laboratory analysis
Interfering Factors
- ●Poor sample quality or hemolysis
- ●Contamination during collection or transport
- ●Improper sample storage (e.g., freezing)
- ●Insufficient sample volume
Compare With Similar Tests
| Test | FISH - t(8;14) or MYC/IGH for Burkitt & Non-Hodgkin Lymphoma Test | FISH for t(14;18) BCL2/IGH | Biopsy and Histopathology |
|---|---|---|---|
| Comparison | FISH - t(8;14) or MYC/IGH for Burkitt & Non-Hodgkin Lymphoma Test |
Frequently Asked Questions
What is the FISH t(8;14) or MYC/IGH test?
Why is this test recommended?
What sample is required for the test?
How is the test performed?
What do the results mean?
What is the cost of the test?
Is home collection available?
How long does it take to get results?
Are there any risks associated with the test?
Can this test detect other types of lymphoma?
How should I prepare for the test?
What happens if the test is positive?
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