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FISH - t(8;21) or LSI ETO/AML1 Test

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FISH - t(8;21) or LSI ETO/AML1 Test

Short Name: FISH - t(8;21)

Also known as: LSI ETO/AML1 Test, t(8;21) FISH Test

FISH - t(8;21) or LSI ETO/AML1 Test test available at DNA Labs India for ₹6,000. Uses FISH on Whole blood or bone marrow samples. Results in Report available within 4 working days after sample collection.. Free home collection in 300+ cities across India.

Oncology🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect the t(8;21) translocation for diagnosing Acute Myeloid Leukemia (AML).

Test Code
561
Price
₹6,000
Sample Type
Whole blood or bone marrow
Result Time
Report available within 4 working days after sample collection.
Fasting Required
No
Method
FISH
Step 1

Sample Collection

Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.

Method: Blood draw or bone marrow aspiration

Step 2

Laboratory Analysis

Collection of whole blood or bone marrow sample by a trained healthcare professional.

Step 3

Report Delivery

Sample must be shipped at 18-22°C. Do not freeze.

Timeline: Report available within 4 working days after sample collection.

Patient Instructions

1
Before the Test:Ensure the Chromosome & FISH analysis Requisition Form (Form 17) is duly filled. No specific fasting is required.
2
During the Test:Blood draw or bone marrow aspiration procedure performed by a trained professional.
3
After the Test:Sample sent to the laboratory. Report is available within 4 working days.

About This Test

Who Should Get This Test

To detect the t(8;21) translocation for diagnosing Acute Myeloid Leukemia (AML).

How to Prepare

  • 5 mL (3 mL min.) whole blood OR 4 mL (2 mL min.) bone marrow from 2 Green Top (Sodium Heparin) tubes
  • Ship at 18-22°C. DO NOT FREEZE
  • Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"The (8;21) translocation occurs in approximately 5% of AML & is usually associated with a high rate of complete remission and longer overall survival in AML subtype M2."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood or bone marrow
Sample Volume5 mL whole blood or 4 mL bone marrow
Container2 Green Top (Sodium Heparin) tubes
Collection MethodBlood draw or bone marrow aspiration

Sample Stability

Room Temperature: 48 hrs
Refrigerator: NA
Frozen: NA
Sample Rejection Criteria:
  • Improper sample collection
  • Missing or incomplete requisition form
  • Hemolyzed, clotted, or insufficient sample volume

Understanding Your Results

Results indicate the presence or absence of t(8;21) translocation, which is critical for diagnosing AML subtype M2.
📊

Negative

No t(8;21) translocation detected. Further tests may be needed if symptoms persist.

📊

Positive

t(8;21) translocation detected, confirming AML associated with this genetic abnormality. Consult an oncologist for treatment planning.

⚠️ When to Consult a Doctor:

If you experience symptoms like fatigue, bleeding, or have been diagnosed with AML, consult an oncologist or hematologist immediately.

Limitations

  • ⚠FISH test is specific for t(8;21) translocation and may not detect other genetic abnormalities
  • ⚠Results depend on sample adequacy and laboratory conditions

Risks & Considerations

  • ●Pain or discomfort at the collection site
  • ●Risk of infection or bleeding, especially with bone marrow aspiration

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Improper sample storage

Compare With Similar Tests

TestFISH - t(8;21) or LSI ETO/AML1 TestFISH - BCR/ABLCytogenetics AnalysisBone Marrow Biopsy
ComparisonFISH - t(8;21) or LSI ETO/AML1 Test

Frequently Asked Questions

What is the FISH - t(8;21) or LSI ETO/AML1 Test?
It is a genetic test using FISH to detect the translocation between chromosomes 8 and 21, associated with Acute Myeloid Leukemia (AML).
What does this test detect?
It detects the presence of t(8;21) translocation, which is a genetic abnormality linked to AML subtype M2.
What symptoms may indicate the need for this test?
Symptoms include fatigue, shortness of breath, pale skin, easy bruising or bleeding, fever, weight loss, and bone pain.
How is the test performed?
The test involves collecting a blood or bone marrow sample and analyzing it using FISH technology in a laboratory.
What sample is required for the test?
5 mL of whole blood or 4 mL of bone marrow collected in Sodium Heparin tubes.
Is fasting required for this test?
No, fasting is not required, but a duly filled requisition form (Form 17) is mandatory.
How much does the test cost?
The test costs INR 6000, with free home sample collection available across India.
How long does it take to get the results?
Results are typically available within 4 working days after sample collection.
What does a positive result mean?
A positive result confirms the presence of t(8;21) translocation, indicating AML associated with this genetic abnormality.
What should I do if my result is positive?
Consult an oncologist or hematologist immediately for diagnosis confirmation and treatment planning.
Are there any risks associated with the test?
Risks include pain or discomfort at the collection site and minimal risk of infection or bleeding.
Where can I get this test done?
DNA Labs India offers this test with free home collection in numerous cities. You can book online or contact us for more information.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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