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FOXO1 Break Apart FISH Alveolar Rhabdomyosarcoma Diagnostic Test

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FOXO1 Break Apart FISH Alveolar Rhabdomyosarcoma Diagnostic Test

Short Name: FOXO1 FISH ARMS Diagnostic

Also known as: FOXO1 FISH Test, Alveolar Rhabdomyosarcoma Genetic Test

FOXO1 Break Apart FISH Alveolar Rhabdomyosarcoma Diagnostic Test test available at DNA Labs India for ₹9,000. Uses FISH (Fluorescence In Situ Hybridization) on Tumor tissue samples. Results in 7-8 days. Free home collection in 300+ cities across India.

OncologyChildren and Young Adults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the FOXO1 Break Apart FISH test is to detect specific genetic rearrangements in the FOXO1 gene, which are hallmark features of Alveolar Rhabdomyosarcoma. This aids in accurate diagnosis, subtype classification, and informs targeted therapy decisions.

Test Code
3015
Price
₹9,000
Sample Type
Tumor tissue
Result Time
7-8 days
Fasting Required
No
Method
FISH (Fluorescence In Situ Hybridization)
Step 1

Sample Collection

Ensure a doctor's prescription is available. No specific fasting or preparation is required for tissue biopsy, but follow biopsy site care instructions.

Method: Biopsy

Step 2

Laboratory Analysis

A biopsy procedure will be performed by a healthcare professional to obtain tumor tissue. Local anesthesia may be used.

Step 3

Report Delivery

Apply pressure to the biopsy site to prevent bleeding. Keep the area clean and dry. Monitor for signs of infection.

Timeline: 7-8 days

Patient Instructions

1
Before the Test:No special preparation needed. Ensure biopsy sample is available and doctor's prescription is provided.
2
During the Test:The test involves FISH analysis on tumor tissue samples in a laboratory setting. No patient involvement during testing.
3
After the Test:Results are typically available in 7-8 days. Discuss results with your doctor for next steps.

About This Test

Who Should Get This Test

The purpose of the FOXO1 Break Apart FISH test is to detect specific genetic rearrangements in the FOXO1 gene, which are hallmark features of Alveolar Rhabdomyosarcoma. This aids in accurate diagnosis, subtype classification, and informs targeted therapy decisions.

How to Prepare

  • Obtain tumor tissue via biopsy or surgical excision
  • Preserve tissue in paraffin-embedded blocks
  • Label samples with patient details and test request
  • Transport at ambient temperature to the lab

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"The FOXO1 Break Apart FISH test is essential for precise diagnosis and tailored treatment planning in Alveolar Rhabdomyosarcoma, improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumor tissue
ContainerParaffin-embedded tissue block
Collection MethodBiopsy

Sample Stability

Paraffin-embedded tissue
Sample Rejection Criteria:
  • Insufficient tumor tissue
  • Degraded or necrotic samples
  • Incorrect sample labeling or documentation

Understanding Your Results

Results indicate whether FOXO1 gene rearrangements are present, which are characteristic of Alveolar Rhabdomyosarcoma. Positive results support diagnosis, while negative results may require further testing.
📊

Positive for FOXO1 rearrangement

Strongly suggestive of Alveolar Rhabdomyosarcoma. Correlate with clinical and histopathological data for confirmation.

📊

Negative for FOXO1 rearrangement

FOXO1 rearrangement not detected. Consider other rhabdomyosarcoma subtypes or additional genetic tests.

📊

Inconclusive

Test could not determine rearrangement status. Repeat testing or alternative methods may be needed.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms like persistent lumps, pain, breathing difficulties, or unexplained weight loss, especially in children or young adults. Early consultation is crucial for timely diagnosis and treatment.

Limitations

  • ⚠Test is specific to FOXO1 rearrangements; may not detect other genetic alterations
  • ⚠Requires sufficient tumor cellularity in the sample
  • ⚠Results should be correlated with clinical and histopathological findings

Risks & Considerations

  • ●Minimal risks associated with biopsy, such as infection, bleeding, or pain at the biopsy site
  • ●No direct risks from the FISH test itself as it is performed on tissue samples

Interfering Factors

  • ●Inadequate tumor tissue sample
  • ●Poor tissue preservation
  • ●Technical errors in FISH processing

Frequently Asked Questions

What is the FOXO1 Break Apart FISH test?
It is a diagnostic test that uses Fluorescence In Situ Hybridization to detect rearrangements in the FOXO1 gene, commonly associated with Alveolar Rhabdomyosarcoma.
Who should get this test?
Individuals, especially children and young adults, with symptoms like persistent lumps, pain, or difficulty breathing, or those with suspected soft tissue sarcoma based on clinical evaluation.
How is the sample collected?
The test requires a tumor tissue sample, typically obtained via biopsy or surgical excision, which is then preserved as a paraffin-embedded block.
Is fasting required before the test?
No, fasting is not required as the test involves tissue analysis, not blood or urine samples.
What is the cost of the test?
The FOXO1 Break Apart FISH test costs INR 9000 at DNA Labs India, with home sample collection available.
How long does it take to get results?
Results are typically available within 7-8 days after sample receipt.
What does a positive result mean?
A positive result indicates the presence of FOXO1 gene rearrangements, which strongly supports a diagnosis of Alveolar Rhabdomyosarcoma.
What if the result is negative?
A negative result means no FOXO1 rearrangement was detected. Your doctor may recommend additional tests to rule out other conditions.
Is the test covered by insurance?
Coverage varies by insurance plan. It is advisable to check with your provider or government schemes like PMJAY or CGHS for details.
Are there any risks associated with the test?
The test itself has no direct risks, but the biopsy procedure for sample collection may involve minor risks like infection or bleeding.
Can this test be done at home?
Home sample collection is available for the tissue biopsy, but the biopsy procedure must be performed by a healthcare professional. The test analysis is done in the lab.
How accurate is the FOXO1 Break Apart FISH test?
FISH is a highly accurate method for detecting gene rearrangements, but results should be interpreted alongside clinical and histopathological findings for definitive diagnosis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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