Glioma Panel(MGMT, IDH1&2, FISH 1p19q) Test
Short Name: Glioma Panel
Also known as: Glioma Molecular Panel, MGMT Methylation, IDH1/2 Mutation, 1p/19q Codeletion Panel
Glioma Panel(MGMT, IDH1&2, FISH 1p19q) Test test available at DNA Labs India for ₹36,000. Uses MLPA, FISH, Sanger Sequencing on Tumor tissue (paraffin-embedded block) samples. Results in Reports are typically available within 2-3 weeks after the laboratory receives the sample.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this panel is to provide a comprehensive molecular profile of gliomas to guide diagnosis, prognosis, and treatment planning. It helps differentiate between tumor types, predict response to chemotherapy and radiation, and identify potential targeted therapy options.
- Test Code
- 6104
- CPT Code
- CPT: 81445, 88367, 88368
- ICD Code
- ICD-10: C71.9
- Price
- ₹36,000
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Reports are typically available within 2-3 weeks after the laboratory receives the sample.
- Fasting Required
- No
- Method
- MLPA, FISH, Sanger Sequencing
Sample Collection
A doctor's prescription is required. Inform your doctor about any medications you are taking. No fasting is needed. The test is performed on tumor tissue obtained from biopsy or surgery.
Method: Biopsy or surgical resection specimen
Laboratory Analysis
The sample is collected during a biopsy or surgical procedure. The tissue is placed in a fixative (formalin) and sent to the laboratory.
Report Delivery
No special precautions are needed after sample collection. You can resume normal activities. The report will be available in 2-3 weeks.
Timeline: Reports are typically available within 2-3 weeks after the laboratory receives the sample.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this panel is to provide a comprehensive molecular profile of gliomas to guide diagnosis, prognosis, and treatment planning. It helps differentiate between tumor types, predict response to chemotherapy and radiation, and identify potential targeted therapy options.
How to Prepare
- Tissue sample must be in a paraffin block or unstained slides
- Sample should be accompanied by a pathology report
- Label the container with patient name and ID
- Transport at ambient temperature
- Avoid freezing the sample
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This panel is essential for tailoring glioma treatment. MGMT methylation predicts chemotherapy response, IDH1/2 mutations indicate better prognosis, and 1p/19q codeletion guides oligodendroglioma management. Early testing can significantly impact patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor content (<20%)
- Sample not fixed properly
- Sample with extensive necrosis
- Incorrect labeling or missing requisition form
Understanding Your Results
MGMT methylated
Higher likelihood of response to temozolomide and radiation; consider alkylating chemotherapy
MGMT unmethylated
Lower response to temozolomide; alternative therapies may be considered
IDH1/2 mutant
Better prognosis; may be eligible for IDH inhibitors in clinical trials
IDH1/2 wild type
Typically associated with primary glioblastoma; more aggressive course
1p/19q codeletion
Confirms oligodendroglioma; predicts favorable response to PCV chemotherapy and radiation
No 1p/19q codeletion
Suggests astrocytic lineage; management differs
Consult your oncologist if you have been diagnosed with a glioma and have not undergone molecular testing. Also, seek medical advice if you experience new or worsening neurological symptoms such as persistent headaches, seizures, or weakness.
Limitations
- ⚠This panel does not detect all possible glioma-related mutations
- ⚠MGMT methylation testing by MLPA may not capture all methylation sites
- ⚠FISH may miss small deletions or complex rearrangements
- ⚠Results should be interpreted in conjunction with histopathology and imaging
- ⚠Not a screening test for healthy individuals
Risks & Considerations
- ●No direct risks from the test itself, as it is performed on tissue already removed
- ●Risks associated with biopsy or surgery (e.g., bleeding, infection) are explained by the surgeon
Interfering Factors
- ●Inadequate tumor tissue sample
- ●Decalcification of bone specimens may degrade DNA
- ●Prolonged formalin fixation (>24 hours) can fragment DNA
- ●Necrotic tissue may yield false-negative results
- ●Previous chemotherapy or radiation may alter molecular markers
Compare With Similar Tests
| Test | Glioma Panel(MGMT, IDH1&2, FISH 1p19q) | MGMT Methylation Only | IDH1/2 Mutation Only | FISH 1p19q Only | Comprehensive Glioma Panel |
|---|---|---|---|---|---|
| Comparison | Glioma Panel(MGMT, IDH1&2, FISH 1p19q) |
Frequently Asked Questions
What is the cost of the Glioma Panel (MGMT, IDH1&2, FISH 1p19q) at DNA Labs India?
What sample is required for this test?
Is fasting required before the test?
How long does it take to get the results?
What is the significance of MGMT methylation?
What does IDH1/2 mutation mean?
What is 1p/19q codeletion?
Do I need a doctor's prescription for this test?
Is home sample collection available?
Can this test be done on a blood sample?
What is the difference between this panel and individual tests?
Are the results confidential?
Related Tests
B-Cell Rearrangement Detection Test
₹22,000Acute Lymphoblastic Leukemia (ALL) Cytogenetics Panel Test
₹20,000Epstein-Barr Virus Early RNA (EBER-ISH) In-Situ-Hybridization Test
₹6,000OncoPro NCCN Lung Cancer Panel with PD-L1 Test
₹140,400Acute Myeloid Leukemia (AML) Cytogenetics Panel Test
₹23,000AML ETO t(8;21) Gene Rearrangement PCR Qualitative Test
₹6,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.