Histone Antibodies Test
Short Name: Histone Antibodies
Also known as: Anti-histone Antibodies Test, Histone Antibody Test
Histone Antibodies Test test available at DNA Labs India for ₹1,580. Uses Enzyme Immunoassay on Serum samples. Results in Same day if sample received by Thursday 9 am; otherwise, report delivery within 24-48 hours.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To detect the presence of histone antibodies in the blood, aiding in the diagnosis of autoimmune diseases such as systemic lupus erythematosus (SLE) and drug-induced lupus, and to monitor treatment effectiveness.
- Test Code
- 755
- Price
- ₹1,580
- Sample Type
- Serum
- Result Time
- Same day if sample received by Thursday 9 am; otherwise, report delivery within 24-48 hours.
- Fasting Required
- Yes (12 hours)
- Method
- Enzyme Immunoassay
Sample Collection
Overnight fasting is preferred. Inform your doctor about any medications or supplements.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist.
Report Delivery
Apply pressure to the site to stop bleeding. Resume normal activities unless otherwise advised.
Timeline: Same day if sample received by Thursday 9 am; otherwise, report delivery within 24-48 hours.
Patient Instructions
About This Test
Who Should Get This Test
To detect the presence of histone antibodies in the blood, aiding in the diagnosis of autoimmune diseases such as systemic lupus erythematosus (SLE) and drug-induced lupus, and to monitor treatment effectiveness.
How to Prepare
- Collect 2 mL blood in SST tube
- Ship refrigerated or frozen
- Overnight fasting preferred for accurate results
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Histone antibodies are present in 80-95% of drug-induced lupus cases and 20-50% of idiopathic SLE, making this test crucial for accurate diagnosis and monitoring of autoimmune conditions. Early detection can prevent long-term damage and improve patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient volume
- Improper storage conditions
Understanding Your Results
Positive
Suggestive of autoimmune disease; further testing and clinical evaluation recommended
Negative
Unlikely to have histone antibody-associated conditions; but does not rule out other autoimmune disorders
If you experience symptoms like fatigue, joint pain, rashes, or if your test result is positive, consult a rheumatologist or immunologist for further evaluation and management.
Limitations
- ⚠May be positive in other autoimmune diseases
- ⚠Not specific for SLE alone
- ⚠Requires clinical correlation for diagnosis
Risks & Considerations
- ●Minor bruising or pain at the needle site
- ●Rarely, fainting or dizziness during blood draw
Interfering Factors
- ●Recent vaccinations
- ●Active infections
- ●Medications affecting the immune system
Frequently Asked Questions
What is the Histone Antibodies Test?
Why might I need this test?
What are the symptoms of autoimmune diseases related to histone antibodies?
How is the test performed?
What is the cost of the Histone Antibodies Test?
Is fasting required for this test?
What does a positive result mean?
What is the turnaround time for results?
Is home sample collection available?
Can this test be used to monitor treatment?
Are there any risks associated with the test?
How accurate is the Histone Antibodies Test?
Related Tests
ANCA (Antineutrophil Cytoplasmic Antibodies) IFA Test
₹1,989ANCA (Anti Neutrophil Cytoplasmic Antibodies) Positive Reflex to ANCA-MPO & ANCA-PR3 Test
₹5,000ANCA (Antineutrophil Cytoplasmic Antibodies) IFA in Dilutions Test
₹5,000Anti-ss DNA Antibody Test
₹3,500ANCA (Anti-Neutrophil Cytoplasmic Antibodies) Extended Profile IgG Test
₹9,500Anti-ds DNA Antibody Crithidia IFA in Dilutions Test
₹4,500Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.