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DNA Labs India

HLA Typing Test for Donor and Recipient Test

DNA Labs India | ISO 9001:2015 Certified

HLA Typing Test for Donor and Recipient Test

Short Name: HLA Typing Test

Also known as: HLA DNA High-Resolution Typing, Human Leukocyte Antigen Typing, Donor-Recipient HLA Matching

HLA Typing Test for Donor and Recipient Test test available at DNA Labs India for ₹16,000. Uses Next-Generation Sequencing (NGS) on Whole blood or buccal swab samples. Results in Reports are typically available within 12-15 days after sample receipt.. Free home collection in 300+ cities across India.

HLA Typing Test🏠 Home Collection

🩺 Medically Reviewed By

Overview

The purpose of HLA typing is to evaluate donor-recipient compatibility in organ transplantation, bone marrow transplants, and related medical procedures. By detecting specific HLA antigens, the test helps predict the likelihood of immune rejection, enabling better clinical decisions to improve transplant success and patient safety.

Test Code
808
Price
₹16,000
Sample Type
Whole blood or buccal swab
Result Time
Reports are typically available within 12-15 days after sample receipt.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Inform the lab of any recent transfusions or medications.

Method: Blood draw or buccal swab collection

Step 2

Laboratory Analysis

Collection by trained phlebotomist or personnel via blood draw or buccal swab.

Step 3

Report Delivery

Sample must be shipped refrigerated. Do not freeze. Handle with care to avoid contamination.

Timeline: Reports are typically available within 12-15 days after sample receipt.

Patient Instructions

1
Before the Test:No special preparation required. Ensure accurate patient identification.
2
During the Test:Sample collection and submission to the laboratory for NGS-based analysis.
3
After the Test:Await results and schedule a follow-up with your doctor to discuss findings.

About This Test

Who Should Get This Test

The purpose of HLA typing is to evaluate donor-recipient compatibility in organ transplantation, bone marrow transplants, and related medical procedures. By detecting specific HLA antigens, the test helps predict the likelihood of immune rejection, enabling better clinical decisions to improve transplant success and patient safety.

How to Prepare

  • Use specified tubes or sterile containers
  • Ship refrigerated at 2-8°C
  • Do not freeze the sample
  • Label samples accurately with patient details

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"HLA typing is essential for predicting transplant rejection and optimizing donor-recipient matching. High-resolution NGS ensures precise antigen detection, crucial for successful transplantation outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood or buccal swab
Sample Volume4 mL or 6 mL whole blood, or buccal swab
ContainerLavender Top (EDTA) tube or Yellow Top (ACD) tube or sterile container for buccal swab
Collection MethodBlood draw or buccal swab collection

Sample Stability

Room Temperature: Not applicable
Refrigerator: 96 hours
Frozen: Not applicable
Sample Rejection Criteria:
  • Hemolyzed or lipemic samples
  • Insufficient sample volume
  • Improper labeling or documentation
  • Sample stored at incorrect temperature

Understanding Your Results

HLA typing results indicate the specific HLA antigens detected. In transplantation, a closer match between donor and recipient HLA antigens is associated with reduced rejection risk and improved graft survival.
High-resolution matching at 4-digit level is recommended for bone marrow transplants
Results are compared to identify best possible donor-recipient pairs
Consult a transplant specialist for clinical correlation
Antibody screening may be needed alongside HLA typing for comprehensive assessment
⚠️ When to Consult a Doctor:

Consult your transplant specialist or immunologist to discuss HLA typing results and their implications for transplantation planning, especially if mismatches are detected.

Limitations

  • May not detect all rare or novel HLA alleles
  • Results require interpretation by a qualified clinician
  • Test accuracy depends on sample quality and laboratory expertise
  • Does not replace other compatibility tests like crossmatch

Risks & Considerations

  • Minimal risk from blood draw, such as bruising or discomfort
  • Very low risk of infection at collection site
  • No significant risks associated with buccal swab collection

Interfering Factors

  • Recent blood transfusions may affect results
  • Contaminated or improperly stored samples
  • Use of certain immunosuppressive medications
  • Sample hemolysis or insufficient volume

Compare With Similar Tests

TestHLA Typing Test for Donor and RecipientCrossmatch TestPanel Reactive Antibody (PRA) Test
ComparisonHLA Typing Test for Donor and RecipientCrossmatch tests serum compatibility for antibodies, while HLA typing assesses genetic compatibility of antigens.PRA measures preformed antibodies against HLA antigens, complementing HLA typing for transplant evaluation.

Frequently Asked Questions

What is HLA typing?
HLA typing is a diagnostic test that identifies Human Leukocyte Antigen (HLA) proteins on cell surfaces, crucial for immune system function and compatibility assessment in transplantation.
Why is HLA typing necessary for organ transplantation?
It helps match donor and recipient HLA antigens to minimize the risk of organ rejection and improve transplant success rates.
How is the HLA typing test performed?
The test uses Next-Generation Sequencing (NGS) on a blood or buccal swab sample to detect HLA alleles at high resolution.
What sample is required for the test?
A 4 mL or 6 mL whole blood sample in specific tubes or a buccal swab collected in a sterile container.
What is the cost of the HLA typing test?
The test costs INR 16000 at DNA Labs India, with free home sample collection available in multiple cities.
How long does it take to get the results?
Results are delivered within 12-15 days after sample collection.
Is home sample collection available?
Yes, free home sample collection is offered for online bookings across India.
What are the symptoms of HLA incompatibility?
Symptoms may include fever, chills, shortness of breath, chest pain, abdominal pain, and vomiting post-transplant.
How is HLA incompatibility diagnosed?
It is diagnosed through HLA typing, biopsy of transplanted organ, antibody screening tests, and immunofluorescence assays.
What does high-resolution HLA typing mean?
High-resolution typing specifies HLA alleles at a minimum of 4 digits, excluding non-expressed alleles, for precise matching in procedures like bone marrow transplants.
Is the test covered by insurance?
Coverage varies; check with your insurance provider. Many schemes may not cover this test, so it's advisable to verify.
How can I book the HLA typing test?
You can book the test online via DNA Labs India's website or contact their customer service for assistance.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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Your Data Privacy

Your medical data is protected under Indian law.

Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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