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HLA - DR (Class II) Typing Test

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HLA - DR (Class II) Typing Test

Short Name: HLA-DR Class II Typing

Also known as: HLA-DRB1 Typing, Class II HLA Typing

HLA - DR (Class II) Typing Test test available at DNA Labs India for ₹8,658. Uses Reverse SSOP - Luminex on Whole Blood samples. Results in Results are typically available within 10-12 days after sample receipt.. Free home collection in 300+ cities across India.

Immunological Typing Test🏠 Home Collection

Overview

The primary purpose of the HLA-DR Class II Typing Test is to evaluate immune system compatibility for organ transplantation and to identify genetic markers associated with autoimmune diseases. It aids in ensuring donor-recipient matches to minimize rejection risks and supports diagnosis and management of conditions like multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.

Test Code
787
Price
₹8,658
Sample Type
Whole Blood
Result Time
Results are typically available within 10-12 days after sample receipt.
Fasting Required
No
Method
Reverse SSOP - Luminex
Step 1

Sample Collection

Obtain a doctor's prescription on letterhead with stamped photographs of recipient and donor. Complete the Consent form for HLA Typing for Solid organ transplant (Form 33). No special preparation required otherwise.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard venipuncture procedure to collect whole blood into specified tubes.

Step 3

Report Delivery

Ship refrigerated; do not freeze. Keep sample stable as per instructions.

Timeline: Results are typically available within 10-12 days after sample receipt.

Patient Instructions

1
Before the Test:Ensure mandatory documentation is prepared. No fasting or special preparation needed.
2
During the Test:Blood sample collected via venipuncture into appropriate tubes.
3
After the Test:No immediate restrictions; follow-up as per physician instructions.

About This Test

Who Should Get This Test

The primary purpose of the HLA-DR Class II Typing Test is to evaluate immune system compatibility for organ transplantation and to identify genetic markers associated with autoimmune diseases. It aids in ensuring donor-recipient matches to minimize rejection risks and supports diagnosis and management of conditions like multiple sclerosis, rheumatoid arthritis, and type 1 diabetes.

How to Prepare

  • Use 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube
  • Ship refrigerated; DO NOT FREEZE
  • Include doctor's prescription and consent form as required

Doctor's Notes

"The classic MHC Class II HLA DR antigens are integral participants in the immune response to intracellular infections, tumors, and allografts. They show a high degree of allelic variation, which is crucial for assessing transplant compatibility and autoimmune disease risk."

Test Parameters & Specifications

Sample TypeWhole Blood
Sample Volume4 mL (3 mL min.) in Lavender Top (EDTA) tube OR 6 mL (3 mL min.) in Yellow Top (ACD) tube
ContainerLavender Top (EDTA) tube or Yellow Top (ACD) tube
Collection MethodVenipuncture

Sample Stability

Room TemperatureNot Applicable
Refrigerator96 hours
FrozenNot Applicable
Sample Rejection Criteria:
  • Sample not collected in specified container
  • Insufficient sample volume
  • Missing required documentation (prescription and consent form)
  • Sample hemolyzed or contaminated

Understanding Your Results

Results are interpreted based on the detection of specific HLA-DR alleles, which indicate compatibility for transplants or genetic predisposition to autoimmune diseases. Positive detection of certain alleles may increase risk, but clinical correlation is essential.
Review detected HLA-DR alleles with respect to donor-recipient match
Correlate with clinical history and other diagnostic tests for autoimmune conditions
Consult with transplant specialist or immunologist for detailed guidance
Note that results are categorical and may require follow-up testing
⚠️ When to Consult a Doctor:

Consult a healthcare provider after receiving results to discuss implications for transplantation or autoimmune disease management. Immediate consultation is advised if the test is part of an ongoing transplant evaluation.

Limitations

  • May not detect all rare HLA alleles
  • Results are for compatibility and predisposition, not definitive diagnosis of diseases
  • Requires mandatory documentation for solid organ transplants

Risks & Considerations

  • Minor bruising or pain at blood draw site
  • Rare risk of infection
  • No significant long-term risks

Interfering Factors

  • Hemolysis or improper sample handling
  • Contamination during collection
  • Incorrect sample storage conditions

Compare With Similar Tests

TestHLA - DR (Class II) Typing TestHLA-A, B, C TypingHLA-DQ TypingComprehensive HLA Panel
ComparisonHLA - DR (Class II) Typing Test

Frequently Asked Questions

What is the HLA-DR Class II Typing Test?
It is an immunological test that identifies specific HLA-DR alleles to assess compatibility for organ transplants and genetic risk for autoimmune diseases.
Why is this test important for organ transplants?
It helps ensure donor-recipient compatibility to reduce the risk of transplant rejection by evaluating immune system matches.
What diseases are associated with HLA-DR typing?
Autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and type 1 diabetes have genetic links to certain HLA-DR alleles.
How is the test performed?
A blood sample is collected and analyzed using methods like Reverse SSOP - Luminex to detect HLA-DR alleles.
What documents are required for the test?
A doctor's prescription on letterhead with stamped photographs of recipient and donor, and a Consent form for HLA Typing for Solid organ transplant (Form 33) are mandatory.
How long does it take to get results?
Results are typically available within 10-12 days after the sample is received at the laboratory.
Is home collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings across various cities in India.
What is the cost of the test?
The test costs INR 8658.0 at DNA Labs India, with special discounted pricing available.
Are there any risks associated with the test?
Risks are minimal and include minor bruising or discomfort at the blood draw site, similar to standard blood tests.
Can the test be used for autoimmune disease diagnosis?
No, it is not a diagnostic test but helps identify genetic predisposition; diagnosis requires clinical evaluation and other tests.
What is the difference between Class I and Class II HLA typing?
Class I HLA antigens (e.g., HLA-A, B, C) are involved in immune responses to viruses, while Class II (e.g., HLA-DR) are key for transplant compatibility and autoimmune associations.
How should I prepare for the test?
No special preparation is required, but ensure all mandatory documentation is ready prior to sample collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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