HLA - DR4 (DRB1*04) Test
Short Name: HLA-DR4 Test
Also known as: HLA-DRB1*04 Test, DR4 Gene Test, Human Leukocyte Antigen DR4 Test
HLA - DR4 (DRB1*04) Test test available at DNA Labs India for ₹6,000. Uses Reverse SSOP - Luminex on Whole blood samples. Results in Reports available within 10-12 days via online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To determine the presence of the HLA-DRB1*04 allele, which is associated with a higher risk of developing autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. This information aids in diagnosis, prognosis, treatment planning, and preventive measures for individuals with a family history or symptoms of these conditions.
- Test Code
- 792
- Price
- ₹6,000
- Sample Type
- Whole blood
- Result Time
- Reports available within 10-12 days via online portal, email, or WhatsApp.
- Fasting Required
- No
- Method
- Reverse SSOP - Luminex
Sample Collection
No special preparation required. Inform your doctor about any medications or supplements you are taking.
Method: Blood draw by phlebotomy
Laboratory Analysis
A healthcare professional will draw blood from a vein in your arm using standard phlebotomy techniques.
Report Delivery
Apply pressure to the puncture site to prevent bruising. Resume normal activities unless advised otherwise.
Timeline: Reports available within 10-12 days via online portal, email, or WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
To determine the presence of the HLA-DRB1*04 allele, which is associated with a higher risk of developing autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. This information aids in diagnosis, prognosis, treatment planning, and preventive measures for individuals with a family history or symptoms of these conditions.
How to Prepare
- Collect 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube.
- Ship refrigerated. DO NOT FREEZE.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for assessing genetic susceptibility to autoimmune conditions, aiding in early diagnosis and personalized management plans."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Frozen samples
- Clotted or hemolyzed blood
- Incorrect container or insufficient volume
Understanding Your Results
Positive
Presence of HLA-DRB1*04 allele. Increased risk for conditions like rheumatoid arthritis. Recommend clinical correlation and monitoring.
Negative
Absence of HLA-DRB1*04 allele. Lower genetic risk, but does not rule out autoimmune diseases. Consider other diagnostic tests if symptoms persist.
Consult a doctor if you experience symptoms of autoimmune diseases (e.g., persistent joint pain, fatigue, skin rashes) or have a family history of such conditions. Also, seek guidance after receiving test results to understand implications and next steps.
Limitations
- ⚠This test does not diagnose autoimmune diseases alone; must be used with clinical evaluation.
- ⚠False positives or negatives can occur due to technical issues.
- ⚠Results may vary based on laboratory methods and sample quality.
Risks & Considerations
- ●Minor bruising or pain at blood draw site
- ●Rare risk of infection or fainting
- ●No significant long-term risks
Interfering Factors
- ●Improper sample storage (e.g., freezing)
- ●Sample contamination
- ●Hemolyzed or lipemic blood samples
Compare With Similar Tests
| Test | HLA - DR4 (DRB1*04) Test | HLA-B27 Test | Anti-CCP Antibody Test | Rheumatoid Factor Test | HLA-DR3 Test |
|---|---|---|---|---|---|
| Comparison | HLA - DR4 (DRB1*04) Test | Detects HLA-B27 associated with ankylosing spondylitis; HLA-DR4 focuses on autoimmune arthritis risk. | Used for rheumatoid arthritis diagnosis; HLA-DR4 is a genetic risk marker, while Anti-CCP is an antibody test. | Measures antibodies in rheumatoid arthritis; HLA-DR4 assesses genetic predisposition, not current disease activity. | Another HLA allele associated with autoimmune diseases like type 1 diabetes; similar methodology but different genetic markers. |
Frequently Asked Questions
What is the HLA-DR4 test?
Why is HLA-DR4 testing important?
What symptoms may indicate a need for this test?
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What is the cost of the HLA-DR4 test at DNA Labs India?
Is fasting required for the HLA-DR4 test?
How long does it take to get the results?
What does a positive HLA-DR4 result mean?
Can a negative HLA-DR4 result rule out autoimmune diseases?
Are there any risks associated with the HLA-DR4 test?
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