IgVH Hypermuation Analysis Confirmatory Test
Short Name: IgVH Mutation Test
Also known as: IgVH Mutation Status Test, IGHV Hypermutation Analysis, Immunoglobulin Variable Heavy Chain Mutation Test
IgVH Hypermuation Analysis Confirmatory Test test available at DNA Labs India for ₹25,000. Uses Next Generation Sequencing (NGS) on Whole Blood samples. Results in Report available within 10 days of sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the IgVH Hypermutation Analysis Confirmatory Test is to determine the mutational status of the IgVH gene in lymphocytes. This information helps in confirming the diagnosis of CLL or SLL, assessing prognosis, and making informed decisions about treatment. It also detects clonal expansions that may be missed by other methods.
- Test Code
- 856
- Price
- ₹25,000
- Sample Type
- Whole Blood
- Result Time
- Report available within 10 days of sample collection.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No special preparation required. Inform your doctor about any medications or health conditions.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm using standard venipuncture technique by a trained phlebotomist.
Report Delivery
Apply pressure to the puncture site and keep it bandaged. Resume normal activities immediately.
Timeline: Report available within 10 days of sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the IgVH Hypermutation Analysis Confirmatory Test is to determine the mutational status of the IgVH gene in lymphocytes. This information helps in confirming the diagnosis of CLL or SLL, assessing prognosis, and making informed decisions about treatment. It also detects clonal expansions that may be missed by other methods.
How to Prepare
- Collect 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube.
- Ship refrigerated. DO NOT FREEZE.
- Label tube with patient name and details.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The IgVH Hypermutation status is a key prognostic marker in CLL, helping to guide treatment decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient volume (<2 mL)
- Incorrect container type
- Improper labeling or missing details
Understanding Your Results
Typically favorable prognosis, slower disease progression. Often responds better to treatment.
Status: Mutated IgVH
Often associated with more aggressive disease, poorer outcome, and may require intensive therapy.
Status: Unmutated IgVH
Indicates complex disease biology, which may influence treatment decisions and monitoring.
Status: Bi-clonal/Multi-clonal expansion
If you experience symptoms such as enlarged lymph nodes, fatigue, weight loss, or night sweats, or if your test results are abnormal, consult your oncologist immediately for further evaluation and management.
Limitations
- ⚠Cannot detect all genetic mutations.
- ⚠Results should be correlated with clinical findings.
- ⚠Limited to IgVH analysis; other markers may be needed for comprehensive diagnosis.
Risks & Considerations
- ●Minor pain or bruising at the blood draw site.
- ●Very rare risk of infection or fainting.
Interfering Factors
- ●Hemolyzed or lipemic samples may affect results.
- ●Insufficient sample volume.
- ●Contamination during sample processing.
Compare With Similar Tests
| Test | IgVH Hypermuation Analysis Confirmatory Test | |||
|---|---|---|---|---|
| Comparison | IgVH Hypermuation Analysis Confirmatory Test |
Frequently Asked Questions
What is the IgVH Hypermutation Analysis Confirmatory Test?
Who should take this test?
How is the test performed?
What does a mutated IgVH result mean?
What does an unmutated IgVH result mean?
Is there any preparation required before the test?
How long does it take to get the results?
What is the cost of the test?
Is home collection available for this test?
Can this test detect all types of CLL?
What are the limitations of this test?
How does this test differ from other genetic tests for CLL?
Related Tests
B-Cell Rearrangement Detection Test
₹22,000Acute Lymphoblastic Leukemia (ALL) Cytogenetics Panel Test
₹20,000Epstein-Barr Virus Early RNA (EBER-ISH) In-Situ-Hybridization Test
₹6,000OncoPro NCCN Lung Cancer Panel with PD-L1 Test
₹140,400Acute Myeloid Leukemia (AML) Cytogenetics Panel Test
₹23,000AML ETO t(8;21) Gene Rearrangement PCR Qualitative Test
₹6,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.