Immunosuppressant Drug Profile 2 Test
Short Name: ISP2 Test
Also known as: Cyclosporine and Sirolimus Test, Immunosuppressant Drug Monitoring
Immunosuppressant Drug Profile 2 Test test available at DNA Labs India for ₹9,500. Uses LC-MS/MS on Whole Blood samples. Results in Same-day reporting for samples received by 5 pm.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
To measure the blood levels of Cyclosporine and Sirolimus, immunosuppressant drugs used in organ transplant and autoimmune diseases, to ensure therapeutic range and prevent toxicity or rejection.
- Test Code
- 1094
- Price
- ₹9,500
- Sample Type
- Whole Blood
- Result Time
- Same-day reporting for samples received by 5 pm.
- Fasting Required
- No
- Method
- LC-MS/MS
Sample Collection
Inform the healthcare provider about the last dose time, amount, and any other medications. Provide date and time of sampling, dose taken, and time of dosing.
Method: Venipuncture
Laboratory Analysis
A healthcare professional will draw a small blood sample from a vein in your arm using standard venipuncture technique.
Report Delivery
Apply pressure to the site with a bandage to prevent bruising. Resume normal activities unless otherwise advised.
Timeline: Same-day reporting for samples received by 5 pm.
Patient Instructions
About This Test
Who Should Get This Test
To measure the blood levels of Cyclosporine and Sirolimus, immunosuppressant drugs used in organ transplant and autoimmune diseases, to ensure therapeutic range and prevent toxicity or rejection.
How to Prepare
- Collect 3 mL (2 mL min.) of whole blood in a Lavender Top (EDTA) tube
- Ideal sampling time: Just before the next dose (trough levels)
- Ship refrigerated to maintain sample stability
- Record date and time of sampling, dose taken, and time of dosing
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"This test is essential for monitoring immunosuppressant drug levels in transplant patients to optimize dosing, prevent rejection, and minimize toxicity."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Improper sample container or anticoagulant
- Sample not refrigerated if required
- Missing critical patient information like dosing time
Understanding Your Results
Drug levels are optimal; continue current dosing with regular monitoring.
Level: Within therapeutic range
Sub-therapeutic levels may risk treatment failure or rejection; consider dose increase under physician guidance.
Level: Below therapeutic range
Elevated levels may indicate toxicity risk; evaluate for side effects and consider dose reduction.
Level: Above therapeutic range
Consult your doctor immediately if you experience symptoms of toxicity (e.g., severe headache, vision changes, swelling) or signs of organ rejection (e.g., fever, pain at transplant site), or if results are outside the therapeutic range.
Limitations
- ⚠Measures only Cyclosporine and Sirolimus; does not cover other immunosuppressant drugs
- ⚠Results must be interpreted alongside clinical symptoms and other laboratory findings
- ⚠Therapeutic ranges are patient-specific and require physician consultation
Risks & Considerations
- ●Minor bruising or pain at the blood draw site
- ●Rare risk of infection or fainting
- ●No significant long-term risks associated with this test
Interfering Factors
- ●Other medications or herbal supplements that interact with immunosuppressants
- ●Liver or kidney function impairment
- ●Time of sample collection relative to dosing
- ●Dietary factors, such as grapefruit juice intake
- ●Patient compliance with dosing schedule
Compare With Similar Tests
| Test | Immunosuppressant Drug Profile 2 Test | Immunosuppressant Drug Profile 1 Test | Therapeutic Drug Monitoring Panel |
|---|---|---|---|
| Comparison | Immunosuppressant Drug Profile 2 Test |
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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