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Inv(16) (AML M4Eo) Test

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Inv(16) (AML M4Eo) Test

Also known as: AML M4Eo, Inv(16) abnormality, Chromosome 16 inversion

Inv(16) (AML M4Eo) Test test available at DNA Labs India for ₹5,250. Uses FISH (Fluorescence In Situ Hybridization) on Bone Marrow / Peripheral blood samples. Results in Results are typically available within 3-4 days after sample receipt.. Free home collection in 300+ cities across India.

Oncology🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To detect the Inv(16) chromosomal abnormality associated with AML M4Eo for accurate diagnosis, treatment planning, and monitoring of acute myeloid leukemia.

Test Code
3061
Price
₹5,250
Sample Type
Bone Marrow / Peripheral blood
Result Time
Results are typically available within 3-4 days after sample receipt.
Fasting Required
No
Method
FISH (Fluorescence In Situ Hybridization)
Step 1

Sample Collection

Obtain a doctor's prescription. Inform the healthcare provider about any medications or medical conditions.

Method: Bone marrow aspiration or venipuncture

Step 2

Laboratory Analysis

Sample collected via bone marrow aspiration or venipuncture using a sodium heparin vacutainer. Procedure may cause minor discomfort.

Step 3

Report Delivery

Apply pressure to the collection site to prevent bleeding. Monitor for signs of infection or excessive bleeding.

Timeline: Results are typically available within 3-4 days after sample receipt.

Patient Instructions

1
Before the Test:Ensure a doctor's prescription is available. No fasting required, but follow any specific instructions from your healthcare provider.
2
During the Test:Sample collection takes a few minutes. Bone marrow aspiration may involve local anesthesia.
3
After the Test:Resume normal activities unless advised otherwise. Wait for the report and follow up with your doctor.

About This Test

Who Should Get This Test

To detect the Inv(16) chromosomal abnormality associated with AML M4Eo for accurate diagnosis, treatment planning, and monitoring of acute myeloid leukemia.

How to Prepare

  • Ensure proper sample labeling with patient details
  • Use sodium heparin vacutainer as specified
  • Transport sample at ambient temperature to the lab promptly

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early detection of Inv(16) through FISH testing is crucial for accurate diagnosis and personalized treatment in AML M4Eo, improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBone Marrow / Peripheral blood
Sample Volume2ml
ContainerSodium Heparin Vacutainer
Collection MethodBone marrow aspiration or venipuncture

Sample Stability

Stable at ambient temperature for up to 24 hours
Avoid freezing or excessive heat exposure
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Incorrect container or anticoagulant used
  • Insufficient sample volume

Understanding Your Results

Results indicate the presence or absence of the Inv(16) chromosomal abnormality, which is key for diagnosing AML M4Eo.
📊

Positive

Inv(16) detected, strongly associated with AML M4Eo. Consult an oncologist for treatment options.

📊

Negative

No Inv(16) detected. Clinical correlation with other tests may be needed if symptoms persist.

⚠️ When to Consult a Doctor:

If you experience symptoms like fatigue, fever, or easy bruising, or if test results are positive, consult an oncologist immediately for further evaluation and management.

Limitations

  • ⚠Test specifically detects Inv(16); other AML abnormalities may require additional tests
  • ⚠Requires expert interpretation by a pathologist
  • ⚠False negatives possible in low-abundance cases

Risks & Considerations

  • ●Minimal risk from sample collection, such as bruising or infection at the site
  • ●Rare allergic reactions to local anesthesia in bone marrow aspiration

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection
  • ●Delayed sample processing

Compare With Similar Tests

TestInv(16) (AML M4Eo)Bone Marrow BiopsyCytogenetic Analysis
ComparisonInv(16) (AML M4Eo)Provides cellular detail but may not detect specific chromosomal abnormalities like Inv(16).Broad chromosomal analysis; FISH for Inv(16) is more targeted and sensitive.

Frequently Asked Questions

What is Inv(16) (AML M4Eo)?
Inv(16) is a chromosomal abnormality where chromosome 16 is inverted, commonly associated with acute myeloid leukemia (AML) subtype M4Eo.
What are the symptoms of Inv(16) (AML M4Eo)?
Symptoms include fatigue, weakness, shortness of breath, pale skin, fever, chills, easy bruising and bleeding, swollen lymph nodes, joint pain, and abdominal swelling.
How is Inv(16) (AML M4Eo) diagnosed?
Diagnosis involves blood tests, bone marrow biopsy, and specific testing like FISH to detect the Inv(16) abnormality.
What is the cost of Inv(16) (AML M4Eo) test in India?
At DNA Labs India, the cost is INR 5250, with free home sample collection available across India.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities across India.
How long does it take to get the results?
Results are typically available within 3-4 days after sample collection.
Do I need a doctor's prescription for this test?
Yes, a doctor's prescription is required, except for surgery, pregnancy cases, or people planning to travel abroad.
What sample type is required for the test?
The test requires bone marrow or peripheral blood samples collected in a sodium heparin vacutainer.
What is the testing method used?
The test uses FISH (Fluorescence In Situ Hybridization) to detect the Inv(16) chromosomal abnormality.
Are there any risks associated with the test?
Risks are minimal and may include bruising, infection, or discomfort at the sample collection site.
How can I prepare for the test?
No special preparation is needed, but ensure you have a doctor's prescription and inform the healthcare provider about any medications.
What should I do if my test results are positive?
If positive, consult an oncologist immediately for further evaluation, diagnosis, and treatment planning.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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