JAK2 Gene Leukemia, acute myelogenous NGS Genetic Test
Short Name: JAK2 AML NGS
Also known as: JAK2 Mutation Analysis, JAK2 NGS Panel, Acute Myelogenous Leukemia Genetic Test
JAK2 Gene Leukemia, acute myelogenous NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect JAK2 gene mutations in patients suspected of having acute myelogenous leukemia or related myeloproliferative disorders. It helps in confirming diagnosis, assessing disease severity, guiding targeted therapy, and monitoring treatment response. NGS technology allows simultaneous analysis of multiple genes, providing a comprehensive mutational profile.
- Test Code
- 5995
- CPT Code
- 81445
- ICD Code
- C92.00
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically delivered within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation required. Inform your doctor about any medications or supplements you are taking.
Method: Venipuncture or FTA card spot
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. If using FTA card, a drop of blood will be placed on the card.
Report Delivery
You can resume normal activities immediately. No restrictions.
Timeline: Reports are typically delivered within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect JAK2 gene mutations in patients suspected of having acute myelogenous leukemia or related myeloproliferative disorders. It helps in confirming diagnosis, assessing disease severity, guiding targeted therapy, and monitoring treatment response. NGS technology allows simultaneous analysis of multiple genes, providing a comprehensive mutational profile.
How to Prepare
- For blood sample: Use EDTA vacutainer, fill to indicated mark, mix gently.
- For FTA card: Apply blood drops to the designated circles, air dry for 30 minutes.
- Label the sample with patient name, date, and time of collection.
- Transport sample to the lab at ambient temperature within 24 hours.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"JAK2 mutations are critical in myeloproliferative neoplasms and AML. NGS provides comprehensive detection of JAK2 and associated mutations, guiding targeted therapy and prognosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Improper labeling
- Sample received after prolonged transit time
Understanding Your Results
JAK2 V617F Positive
Indicates presence of JAK2 mutation, commonly associated with myeloproliferative neoplasms and some AML cases. May guide targeted therapy.
JAK2 Exon 12 Positive
Rare mutation, also associated with myeloproliferative disorders. Clinical significance similar to V617F.
No JAK2 Mutation Detected
No mutation in JAK2 gene found. Other genetic causes should be considered.
Consult your oncologist if you experience persistent fatigue, unexplained fever, easy bruising, or abnormal blood counts. Early diagnosis and treatment are crucial.
Limitations
- ⚠NGS may not detect very large deletions or rearrangements
- ⚠Mutations in genes not covered by the panel will not be identified
- ⚠Results should be interpreted in conjunction with clinical and pathological findings
- ⚠Low-level mutations may be below detection limit
Risks & Considerations
- ●Minimal risk of bleeding or bruising at the puncture site
- ●Slight dizziness or fainting during blood draw
Interfering Factors
- ●Clotted or hemolyzed blood samples may affect DNA quality
- ●Insufficient DNA quantity or quality
- ●Recent blood transfusion may dilute patient's cells
- ●Contamination during sample collection
Compare With Similar Tests
| Test | JAK2 Gene Leukemia, acute myelogenous NGS Genetic Test | JAK2 V617F PCR | JAK2 Exon 12 PCR | Bone Marrow Biopsy |
|---|---|---|---|---|
| Comparison | JAK2 Gene Leukemia, acute myelogenous NGS Genetic Test | Targeted PCR detects only V617F mutation, while NGS covers multiple exons and other genes. | PCR for exon 12 only, less comprehensive than NGS. | Invasive procedure, provides morphological and genetic information, but NGS is non-invasive and more sensitive. |
Frequently Asked Questions
What is the JAK2 gene and how is it related to leukemia?
What is the cost of the JAK2 Gene Leukemia NGS Genetic Test at DNA Labs India?
What sample is required for this test?
How long does it take to get the results?
Is fasting required before the test?
What does NGS technology mean?
Will I receive raw data files with my report?
Can this test detect all JAK2 mutations?
What is the difference between this NGS test and a regular PCR test?
Is home sample collection available in my city?
How should I prepare for the test?
What is the clinical significance of a positive JAK2 mutation result?
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