KRAS Codon 61 Mutation Detection Test
Short Name: KRAS Codon 61 Mutation Test
Also known as: KRAS Codon 61 Test, KRAS Mutation Detection, KRAS Gene Mutation Test
KRAS Codon 61 Mutation Detection Test test available at DNA Labs India for ₹8,500. Uses PCR on Fresh tissue in normal saline OR formalin fixed paraffin embedded block samples. Results in Reports available 15 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
This assay is useful for the detection of KRAS mutations which are associated with shorter progression-free survival in Colorectal cancers. Codon 12 and codon 13 are more prevalent while codon 61 forms less than 1% of KRAS mutations.
- Test Code
- 1145
- Price
- ₹8,500
- Sample Type
- Fresh tissue in normal saline OR formalin fixed paraffin embedded block
- Result Time
- Reports available 15 days after sample receipt.
- Fasting Required
- No
- Method
- PCR
Sample Collection
Ensure the NGS Test Requisition Form (Form 40) is duly filled. Coordinate with the healthcare provider for sample collection.
Method: Tissue biopsy
Laboratory Analysis
Collect tissue biopsy sample using sterile techniques. Place fresh tissue in normal saline or prepare formalin-fixed paraffin-embedded block.
Report Delivery
Ship fresh tissue refrigerated within 72 hours. For FFPE blocks, ensure at least 10% tumor tissue is present.
Timeline: Reports available 15 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
This assay is useful for the detection of KRAS mutations which are associated with shorter progression-free survival in Colorectal cancers. Codon 12 and codon 13 are more prevalent while codon 61 forms less than 1% of KRAS mutations.
How to Prepare
- Submit fresh tissue in normal saline OR formalin fixed paraffin embedded block.
- Ship fresh tissue refrigerated within 72 hours.
- Block should have at least 10% tumor tissue.
- Duly filled NGS Test Requisition Form (Form 40) is mandatory.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test is crucial for identifying KRAS codon 61 mutations, which help guide targeted therapy decisions in colorectal cancer management, improving treatment outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample with insufficient tumor content (<10%)
- Improperly labeled or missing requisition form
- Sample stored beyond stability period
Understanding Your Results
Positive (Mutation Detected)
KRAS codon 61 mutation is present, which may affect response to certain therapies like anti-EGFR treatments. Consider alternative targeted therapies.
Negative (Not Detected)
No KRAS codon 61 mutation detected. This may indicate eligibility for specific treatments, but clinical correlation is essential.
Consult a doctor if experiencing symptoms like abdominal pain, weight loss, or if diagnosed with colorectal cancer for treatment planning based on test results.
Limitations
- ⚠Only detects mutations at codon 61; does not cover other KRAS codons
- ⚠May not identify all types of KRAS mutations
- ⚠Results should be interpreted in conjunction with clinical findings
Risks & Considerations
- ●Minimal risks associated with tissue biopsy, such as infection or bleeding
- ●No direct risks from the genetic test itself
Interfering Factors
- ●Poor sample quality or insufficient tumor tissue
- ●Contamination during sample collection or processing
- ●Improper storage or handling of tissue samples
Compare With Similar Tests
| Test | KRAS Codon 61 Mutation Detection Test | KRAS Codon 12/13 Mutation Test | BRAF Mutation Test | EGFR Mutation Test | NRAS Mutation Test |
|---|---|---|---|---|---|
| Comparison | KRAS Codon 61 Mutation Detection Test |
Frequently Asked Questions
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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