Liquid Bx. Cell Free EGFR [T790M,L858R, Exon 19 Deletion] Test
Short Name: Liquid Biopsy EGFR
Also known as: Cell-Free EGFR Mutation Panel, Liquid Biopsy EGFR T790M, EGFR ctDNA Analysis
Liquid Bx. Cell Free EGFR [T790M,L858R, Exon 19 Deletion] Test test available at DNA Labs India for ₹15,000. Uses Droplet Digital PCR (ddPCR) on Peripheral Blood samples. Results in Reports are typically available within 5-7 days after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify EGFR gene mutations in patients with non-small cell lung cancer (NSCLC) using a simple blood sample. It helps in: 1. Determining eligibility for EGFR-targeted therapies (e.g., gefitinib, erlotinib, osimertinib). 2. Detecting the T790M resistance mutation in patients who have progressed on first-line TKIs. 3. Monitoring treatment response and disease progression through serial ctDNA analysis. 4. Providing a non-invasive alternative when tissue biopsy is not feasible or yields insufficient material. 5. Guiding personalized treatment decisions to improve patient outcomes.
- Test Code
- 6114
- CPT Code
- 81445
- ICD Code
- C34.9
- Price
- ₹15,000
- Sample Type
- Peripheral Blood
- Result Time
- Reports are typically available within 5-7 days after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Droplet Digital PCR (ddPCR)
Sample Collection
No special preparation is required. A doctor's prescription is necessary. Inform your doctor about any ongoing medications or treatments.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist. The procedure is quick and minimally invasive.
Report Delivery
You can resume normal activities immediately. No post-collection restrictions are necessary.
Timeline: Reports are typically available within 5-7 days after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify EGFR gene mutations in patients with non-small cell lung cancer (NSCLC) using a simple blood sample. It helps in: 1. Determining eligibility for EGFR-targeted therapies (e.g., gefitinib, erlotinib, osimertinib). 2. Detecting the T790M resistance mutation in patients who have progressed on first-line TKIs. 3. Monitoring treatment response and disease progression through serial ctDNA analysis. 4. Providing a non-invasive alternative when tissue biopsy is not feasible or yields insufficient material. 5. Guiding personalized treatment decisions to improve patient outcomes.
How to Prepare
- Use Streck Cell-Free DNA BCT for sample collection
- Ensure blood is collected in the provided tube and mixed gently
- Do not refrigerate or freeze the sample
- Transport the sample to the lab within 24 hours at ambient temperature
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Liquid biopsy is a breakthrough for NSCLC management, allowing real-time monitoring of EGFR mutations without invasive tissue biopsy. This test is particularly valuable for detecting T790M resistance mutations, guiding targeted therapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Incorrect tube used
- Sample received after 7 days of collection
- Label mismatch or missing patient information
Understanding Your Results
T790M Detected
Indicates acquired resistance to first-line EGFR TKIs; osimertinib may be recommended.
L858R Detected
Indicates sensitivity to EGFR TKIs such as gefitinib, erlotinib, or afatinib.
Exon 19 Deletion Detected
Indicates sensitivity to EGFR TKIs; associated with better response to therapy.
All Not Detected
No EGFR mutations detected in ctDNA; consider tissue biopsy or other molecular testing.
Consult your oncologist if you experience new or worsening symptoms such as persistent cough, shortness of breath, chest pain, or unexplained weight loss. Also, discuss the results of this test with your doctor to determine the appropriate treatment plan.
Limitations
- ⚠Liquid biopsy may not detect all EGFR mutations due to low ctDNA levels
- ⚠Results should be correlated with clinical and radiological findings
- ⚠Negative results do not rule out the presence of EGFR mutations; tissue biopsy may be needed
- ⚠Test is specific to the three mutations listed and does not cover other EGFR alterations
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the puncture site
- ●Rare risk of infection
- ●Dizziness or fainting during blood draw
Interfering Factors
- ●Hemolysis of blood sample may affect ctDNA quality
- ●Recent chemotherapy or radiation may reduce ctDNA levels
- ●Low tumor burden may lead to false-negative results
- ●Improper sample collection or storage can degrade ctDNA
- ●Presence of clonal hematopoiesis may cause false positives
Compare With Similar Tests
| Test | Liquid Bx. Cell Free EGFR [T790M,L858R, Exon 19 Deletion] | |
|---|---|---|
| Comparison | Liquid Bx. Cell Free EGFR [T790M,L858R, Exon 19 Deletion] |
Frequently Asked Questions
What is a liquid biopsy?
Why is the EGFR T790M mutation important?
How is this test different from a tissue biopsy?
Do I need to fast before the test?
How long does it take to get results?
Is home sample collection available?
What is the cost of the test?
Can this test be done without a doctor's prescription?
What does a 'Not Detected' result mean?
Are there any risks associated with the test?
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