Liquid Bx. Cell Free PAN RAS (KRAS,NRAS) Test
Short Name: Liquid PAN RAS
Also known as: Cell-Free PAN RAS Mutation Panel, Liquid Biopsy KRAS NRAS, ctDNA RAS Panel
Liquid Bx. Cell Free PAN RAS (KRAS,NRAS) Test test available at DNA Labs India for ₹27,000. Uses Droplet Digital PCR on Peripheral Blood samples. Results in Reports are available within 5-7 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Liquid Bx. Cell Free PAN RAS (KRAS,NRAS) test is to identify mutations in the KRAS and NRAS genes from circulating tumor DNA (ctDNA). This helps in: 1) Early detection of cancer, 2) Guiding targeted therapy decisions, 3) Monitoring treatment response, 4) Detecting minimal residual disease, 5) Identifying acquired resistance to anti-EGFR therapy. The test is non-invasive, reducing the need for tissue biopsies, and provides real-time molecular information.
- Test Code
- 6116
- CPT Code
- 81479
- ICD Code
- Z12.9
- Price
- ₹27,000
- Sample Type
- Peripheral Blood
- Result Time
- Reports are available within 5-7 days after sample collection.
- Fasting Required
- No
- Method
- Droplet Digital PCR
Sample Collection
No special preparation is required. However, a doctor's prescription is mandatory. Inform your doctor about any medications you are taking.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. The procedure is quick and minimally invasive.
Report Delivery
You can resume normal activities immediately. No restrictions are required.
Timeline: Reports are available within 5-7 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Liquid Bx. Cell Free PAN RAS (KRAS,NRAS) test is to identify mutations in the KRAS and NRAS genes from circulating tumor DNA (ctDNA). This helps in: 1) Early detection of cancer, 2) Guiding targeted therapy decisions, 3) Monitoring treatment response, 4) Detecting minimal residual disease, 5) Identifying acquired resistance to anti-EGFR therapy. The test is non-invasive, reducing the need for tissue biopsies, and provides real-time molecular information.
How to Prepare
- Use Streck tube for collection
- Fill tube to the indicated mark
- Mix gently by inverting 8-10 times
- Do not refrigerate or freeze
- Transport at ambient temperature (15-25°C)
- Ensure sample reaches lab within 72 hours
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Liquid biopsy for RAS mutations is a breakthrough in personalized oncology, enabling non-invasive monitoring and early detection of resistance."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Hemolyzed sample
- Incorrect tube used
- Sample older than 72 hours
- Insufficient volume
Understanding Your Results
KRAS/NRAS mutation detected
Presence of RAS mutation; may predict resistance to anti-EGFR therapy (e.g., cetuximab, panitumumab) in colorectal cancer.
Action: Discuss alternative targeted therapies or chemotherapy options with oncologist.
KRAS/NRAS mutation not detected
No mutation found in tested hotspots; patient may be eligible for anti-EGFR therapy.
Action: Consider anti-EGFR therapy if clinically indicated.
Inconclusive
Insufficient ctDNA or technical issue; repeat test or consider tissue biopsy.
Action: Repeat test after 2-4 weeks or proceed with tissue biopsy.
Consult your oncologist if you have symptoms like unexplained weight loss, persistent fatigue, blood in stool or urine, persistent pain, or lumps. Also, if you have a family history of cancer, discuss screening options.
Limitations
- ⚠May not detect mutations if ctDNA is below detection limit
- ⚠Not a standalone diagnostic test for cancer
- ⚠Results should be correlated with clinical and radiological findings
- ⚠Cannot detect all RAS mutations (only common hotspots)
- ⚠Not recommended for hematological malignancies
Risks & Considerations
- ●Minimal risk of bruising at puncture site
- ●Rare risk of infection
- ●Fainting or dizziness during blood draw
Interfering Factors
- ●Hemolysis of blood sample
- ●Insufficient blood volume
- ●Sample not collected in Streck tube
- ●Delay in processing beyond 72 hours
- ●High background cfDNA from non-tumor sources
Compare With Similar Tests
| Test | Liquid Bx. Cell Free PAN RAS (KRAS,NRAS) | Tissue Biopsy RAS Testing | Liquid Biopsy (this test) |
|---|---|---|---|
| Comparison | Liquid Bx. Cell Free PAN RAS (KRAS,NRAS) |
Frequently Asked Questions
What is the cost of the Liquid Bx. Cell Free PAN RAS (KRAS,NRAS) test?
What is the sample type required?
Is fasting required before the test?
How long does it take to get results?
Is a doctor's prescription necessary?
What mutations does this test detect?
Is this test covered by insurance?
Can this test detect cancer before symptoms appear?
What is the difference between liquid biopsy and tissue biopsy?
Are there any risks associated with the test?
Can this test be done at home?
What should I do if my result is positive for a mutation?
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