Lung Cancer Panel 1 [EGFR, ALK1] Test
Short Name: Lung Cancer Panel 1
Also known as: EGFR and ALK1 Mutation Panel, Lung Cancer Mutation Panel 1
Lung Cancer Panel 1 [EGFR, ALK1] Test test available at DNA Labs India for ₹18,000. Uses FISH, Sanger Sequencing on Tumor tissue (paraffin-embedded block) samples. Results in Reports are typically available within 5-7 working days after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Lung Cancer Panel 1 is to identify specific genetic alterations in the EGFR and ALK1 genes that are known to drive lung cancer growth. Detection of these mutations enables oncologists to prescribe targeted therapies such as erlotinib, gefitinib, osimertinib (for EGFR) and crizotinib, alectinib (for ALK). This personalized approach improves treatment efficacy, reduces unnecessary side effects, and can lead to better survival rates. The test is particularly recommended for patients with advanced or metastatic non-small cell lung cancer, as well as for those with adenocarcinoma histology, never-smokers, and younger patients who may have a higher likelihood of harboring these mutations.
- Test Code
- 6117
- CPT Code
- 81445
- ICD Code
- C34.90
- Price
- ₹18,000
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Reports are typically available within 5-7 working days after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- FISH, Sanger Sequencing
Sample Collection
No special preparation is required. However, a doctor's prescription is mandatory. Inform your physician about any ongoing medications or supplements.
Method: Biopsy or surgical resection
Laboratory Analysis
The sample is a tumor tissue block or slides obtained from a previous biopsy or surgery. No additional invasive procedure is needed if tissue is already available.
Report Delivery
No specific aftercare is required. You can resume normal activities immediately.
Timeline: Reports are typically available within 5-7 working days after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Lung Cancer Panel 1 is to identify specific genetic alterations in the EGFR and ALK1 genes that are known to drive lung cancer growth. Detection of these mutations enables oncologists to prescribe targeted therapies such as erlotinib, gefitinib, osimertinib (for EGFR) and crizotinib, alectinib (for ALK). This personalized approach improves treatment efficacy, reduces unnecessary side effects, and can lead to better survival rates. The test is particularly recommended for patients with advanced or metastatic non-small cell lung cancer, as well as for those with adenocarcinoma histology, never-smokers, and younger patients who may have a higher likelihood of harboring these mutations.
How to Prepare
- Provide paraffin-embedded tissue block or 5-10 unstained sections on slides.
- Ensure the tissue block is properly labeled with patient details.
- Include a copy of the histopathology report if available.
- If tissue is not available, a fresh biopsy may be required.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This panel is essential for non-small cell lung cancer patients to identify actionable mutations in EGFR and ALK1, guiding targeted therapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate tissue (less than 20% tumor cells)
- Necrotic or degraded tissue
- Incorrect labeling
- Sample not accompanied by prescription
Understanding Your Results
EGFR mutation detected (e.g., exon 19 deletion, L858R)
Patient likely to benefit from EGFR tyrosine kinase inhibitors (e.g., erlotinib, gefitinib, osimertinib).
EGFR T790M mutation detected
Resistance to first-generation TKIs; consider third-generation TKI (osimertinib).
ALK rearrangement positive
Patient likely to benefit from ALK inhibitors (e.g., crizotinib, alectinib).
No mutation/rearrangement detected
No targetable alteration in EGFR/ALK; consider other molecular testing or chemotherapy/immunotherapy.
Consult your oncologist if you have been diagnosed with lung cancer and have not yet undergone molecular testing, or if you experience new or worsening symptoms such as persistent cough, chest pain, shortness of breath, or unexplained weight loss.
Limitations
- ⚠Only detects mutations in EGFR and ALK1; other driver mutations (e.g., ROS1, BRAF) are not covered.
- ⚠Sanger sequencing may miss low-level mutations (<20% allele frequency).
- ⚠FISH may not detect all ALK variants.
- ⚠Results should be interpreted in conjunction with clinical and pathological findings.
Risks & Considerations
- ●No direct risks as the test uses existing tissue samples.
- ●If a fresh biopsy is needed, there are standard risks associated with biopsy procedures (bleeding, infection, pneumothorax).
Interfering Factors
- ●Inadequate tumor tissue sample
- ●Poor DNA quality due to prolonged fixation
- ●Decalcification of bone samples
- ●Necrotic tissue
- ●Low tumor cellularity (<20%)
Compare With Similar Tests
| Test | Lung Cancer Panel 1 [EGFR, ALK1] | Lung Cancer Panel 2 (EGFR, ALK, ROS1, BRAF) | Single EGFR Mutation Test |
|---|---|---|---|
| Comparison | Lung Cancer Panel 1 [EGFR, ALK1] |
Frequently Asked Questions
What is the cost of the Lung Cancer Panel 1 test?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get results?
Is a doctor's prescription necessary?
What genes are analyzed in this panel?
What is the method used for testing?
Can this test be done on a blood sample?
Is home sample collection available?
What is the significance of EGFR and ALK mutations?
Are there any risks associated with this test?
Is this test covered by insurance?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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