Lung Cancer Panel 2 [EGFR,ALK1,ROS1] Test
Short Name: Lung Cancer Panel 2
Also known as: EGFR ALK ROS1 Panel, Lung Cancer Mutation Panel, NSCLC Targeted Gene Panel
Lung Cancer Panel 2 [EGFR,ALK1,ROS1] Test test available at DNA Labs India for ₹22,500. Uses FISH, Sanger Sequencing on Tumor tissue (paraffin-embedded block) samples. Results in Results are typically available within 5-7 business days after the laboratory receives the sample. You will be notified via email or SMS when the report is ready.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Lung Cancer Panel 2 is to identify actionable genetic alterations in the EGFR, ALK1, and ROS1 genes. This information helps oncologists determine whether targeted therapy is appropriate, which can be more effective and less toxic than conventional chemotherapy. It also aids in predicting response to specific inhibitors and monitoring disease progression.
- Test Code
- 6119
- CPT Code
- 81445
- ICD Code
- C34.90
- Price
- ₹22,500
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Results are typically available within 5-7 business days after the laboratory receives the sample. You will be notified via email or SMS when the report is ready.
- Fasting Required
- No
- Method
- FISH, Sanger Sequencing
Sample Collection
A doctor's prescription is required. No special preparation such as fasting is needed. Inform your doctor about any medications you are taking.
Method: Biopsy or surgical resection
Laboratory Analysis
The sample is collected via biopsy or surgical resection. The procedure is performed by a qualified healthcare professional. You may experience mild discomfort at the biopsy site.
Report Delivery
After the procedure, you may resume normal activities unless advised otherwise. The tissue sample is sent to the laboratory for analysis. Results are typically available within 5-7 days.
Timeline: Results are typically available within 5-7 business days after the laboratory receives the sample. You will be notified via email or SMS when the report is ready.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Lung Cancer Panel 2 is to identify actionable genetic alterations in the EGFR, ALK1, and ROS1 genes. This information helps oncologists determine whether targeted therapy is appropriate, which can be more effective and less toxic than conventional chemotherapy. It also aids in predicting response to specific inhibitors and monitoring disease progression.
How to Prepare
- Tumor tissue block must be paraffin-embedded and properly labeled
- Provide the pathology report with the sample
- If sending slides, ensure they are unstained and mounted on charged slides
- Ship at ambient temperature in a leak-proof container
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This panel is essential for guiding targeted therapy in NSCLC. EGFR, ALK, and ROS1 mutations are actionable and can significantly improve treatment outcomes when detected early."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample with insufficient tumor cells (<20% tumor content)
- Decalcified tissue (e.g., bone) that may have degraded DNA
- Sample without proper labeling or requisition form
- Sample received in fixatives other than formalin (e.g., Bouin's solution)
Understanding Your Results
EGFR mutation positive
Eligible for EGFR TKIs (e.g., erlotinib, osimertinib). May also indicate need for resistance testing if previously treated.
ALK1 rearrangement positive
Eligible for ALK inhibitors (e.g., crizotinib, alectinib).
ROS1 rearrangement positive
Eligible for ROS1 inhibitors (e.g., crizotinib, entrectinib).
All negative
No actionable mutations in these genes; consider other molecular testing or chemotherapy/immunotherapy.
Consult your oncologist if you have been diagnosed with NSCLC and have not yet undergone molecular testing. Also, if you experience new or worsening symptoms such as persistent cough, chest pain, or unexplained weight loss, seek medical advice promptly.
Limitations
- ⚠Only detects mutations in the three specified genes; other driver mutations (e.g., BRAF, MET) are not covered
- ⚠Sanger sequencing may miss low-frequency mutations (<15-20% allelic fraction)
- ⚠FISH requires intact nuclei; poor tissue preservation may affect results
- ⚠Results are qualitative; not intended for monitoring minimal residual disease
Risks & Considerations
- ●Bleeding or infection at the biopsy site (rare)
- ●Pneumothorax if lung biopsy is performed (rare)
- ●Pain or discomfort at the biopsy site
- ●Anxiety related to waiting for results
Interfering Factors
- ●Inadequate tumor content in the sample (<20%) may lead to false negatives
- ●Decalcification of bone tissue can degrade DNA quality
- ●Prolonged formalin fixation (>48 hours) may cause DNA cross-linking
- ●Concurrent use of anticoagulants does not affect tissue testing
Compare With Similar Tests
| Test | Lung Cancer Panel 2 [EGFR,ALK1,ROS1] | Lung Cancer Panel 1 (EGFR, ALK, ROS1, BRAF) | Comprehensive Solid Tumor Panel |
|---|---|---|---|
| Comparison | Lung Cancer Panel 2 [EGFR,ALK1,ROS1] |
Frequently Asked Questions
What is the cost of the Lung Cancer Panel 2 test?
What sample is required for this test?
Do I need to fast before the test?
How long does it take to get results?
Is home sample collection available?
What genes are tested in this panel?
Who should get this test?
Can this test be done without a doctor's prescription?
What is the difference between Panel 1 and Panel 2?
Is the test covered by insurance?
What is the turnaround time for reports?
Are there any risks associated with the biopsy?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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