Lung Cancer Panel 3 [EGFR,ALK1,ROS1,MET] Test
Short Name: Lung Cancer Panel 3
Also known as: EGFR ALK ROS1 MET Panel, Lung Cancer Mutation Panel
Lung Cancer Panel 3 [EGFR,ALK1,ROS1,MET] Test test available at DNA Labs India for ₹30,000. Uses FISH, Sanger Sequencing on Tumor tissue (paraffin-embedded block) samples. Results in Reports are typically available within 5-7 business days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the Lung Cancer Panel 3 is to identify specific genetic mutations in the EGFR, ALK1, ROS1, and MET genes that drive the growth of lung cancer cells. This information is crucial for: 1) Selecting targeted therapies that are most likely to be effective, 2) Avoiding treatments that are unlikely to work, 3) Monitoring for resistance mutations, 4) Providing prognostic information, and 5) Guiding clinical trial enrollment. The panel is recommended for patients with newly diagnosed advanced NSCLC, as well as those with progressive disease who may benefit from additional targeted options.
- Test Code
- 6118
- CPT Code
- 81445
- ICD Code
- C34.9
- Price
- ₹30,000
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Reports are typically available within 5-7 business days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- FISH, Sanger Sequencing
Sample Collection
A doctor's prescription is required. For surgical or pregnancy cases, or for those planning to travel abroad, a prescription is not applicable. Please inform your healthcare provider about any medications you are taking.
Method: Biopsy or surgical resection
Laboratory Analysis
The sample is collected via biopsy or surgical resection. The tissue is placed in a paraffin block or on slides. No special preparation is needed.
Report Delivery
The sample is sent to the laboratory. Results are typically available within 5-7 days. Your oncologist will discuss the findings and treatment options.
Timeline: Reports are typically available within 5-7 business days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Lung Cancer Panel 3 is to identify specific genetic mutations in the EGFR, ALK1, ROS1, and MET genes that drive the growth of lung cancer cells. This information is crucial for: 1) Selecting targeted therapies that are most likely to be effective, 2) Avoiding treatments that are unlikely to work, 3) Monitoring for resistance mutations, 4) Providing prognostic information, and 5) Guiding clinical trial enrollment. The panel is recommended for patients with newly diagnosed advanced NSCLC, as well as those with progressive disease who may benefit from additional targeted options.
How to Prepare
- Tumor tissue must be obtained from a biopsy or surgical specimen
- The specimen should be fixed in 10% neutral buffered formalin for no more than 48 hours
- Paraffin-embedded tissue blocks or unstained slides (5-10 sections) are acceptable
- Ensure the sample is labeled with patient identification and collection date
- Ship the sample at ambient temperature in a sturdy container
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This panel is essential for guiding targeted therapy in non-small cell lung cancer. Identifying actionable mutations in EGFR, ALK1, ROS1, and MET can significantly improve treatment outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor cellularity (<20%)
- Decalcified bone specimens
- Necrotic or heavily degraded tissue
- Improper fixation (e.g., Bouin's solution)
- Unlabeled or mislabeled samples
Understanding Your Results
Exon 19 deletion or L858R mutation
Sensitive to EGFR TKIs (e.g., erlotinib, gefitinib, osimertinib)
T790M mutation
Resistance to first-generation TKIs; sensitive to osimertinib
Rearrangement (e.g., EML4-ALK)
Sensitive to ALK inhibitors (e.g., crizotinib, alectinib)
Rearrangement
Sensitive to ROS1 inhibitors (e.g., crizotinib, entrectinib)
Exon 14 skipping mutation or amplification
Sensitive to MET inhibitors (e.g., capmatinib, crizotinib)
If you experience persistent cough, chest pain, shortness of breath, coughing up blood, unexplained weight loss, or hoarseness, consult a healthcare professional immediately. Early diagnosis and molecular testing can significantly improve treatment outcomes.
Limitations
- ⚠This panel only detects mutations in the four specified genes; other driver mutations (e.g., KRAS, BRAF) are not covered
- ⚠Sanger sequencing has limited sensitivity for low-frequency mutations (below 20% allele frequency)
- ⚠FISH may miss small intragenic rearrangements
- ⚠Results are qualitative; quantitative assessment of MET amplification is not provided
- ⚠Tumor heterogeneity may lead to sampling bias
Risks & Considerations
- ●No significant risks associated with the test itself, as it is performed on an existing tissue sample
- ●The biopsy procedure used to obtain the sample carries its own risks (e.g., bleeding, infection), which should be discussed with your doctor
Interfering Factors
- ●Insufficient tumor content in the sample (<20%) may lead to false-negative results
- ●Decalcification of bone specimens can degrade DNA quality
- ●Prolonged formalin fixation (>48 hours) may cause cross-linking and fragmentation
- ●Necrotic tissue may yield poor DNA quality
- ●Concurrent use of certain drugs may affect tumor biology but not test accuracy
Compare With Similar Tests
| Test | Lung Cancer Panel 3 [EGFR,ALK1,ROS1,MET] | |||
|---|---|---|---|---|
| Comparison | Lung Cancer Panel 3 [EGFR,ALK1,ROS1,MET] |
Frequently Asked Questions
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What is the significance of EGFR mutation?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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