Lung Cancer Panel 5 (EGFR,KRAS,BRAF,ALK1,ROS1) Test
Short Name: Lung Cancer Panel 5
Also known as: EGFR KRAS BRAF ALK ROS1 Panel, Lung Cancer Mutation Panel
Lung Cancer Panel 5 (EGFR,KRAS,BRAF,ALK1,ROS1) Test test available at DNA Labs India for ₹36,000. Uses FISH, Sanger Sequencing on Tumor tissue (paraffin-embedded block) samples. Results in Reports are typically available within 5-7 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the Lung Cancer Panel 5 is to detect mutations and rearrangements in the EGFR, KRAS, BRAF, ALK1, and ROS1 genes. These genetic alterations are critical in the pathogenesis of lung cancer and serve as predictive biomarkers for targeted therapies. For example, EGFR mutations predict response to EGFR-TKIs like erlotinib and osimertinib, while ALK and ROS1 rearrangements indicate sensitivity to crizotinib and other ALK/ROS1 inhibitors. KRAS and BRAF mutations help in prognosis and guide treatment decisions, including potential resistance mechanisms. This panel is essential for personalized treatment planning, avoiding ineffective chemotherapy, and identifying patients who may benefit from newer targeted agents or clinical trials.
- Test Code
- 6121
- CPT Code
- 81445
- ICD Code
- C34.9
- Price
- ₹36,000
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Reports are typically available within 5-7 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- FISH, Sanger Sequencing
Sample Collection
No special preparation is required. A doctor's prescription is necessary. Inform your physician about any medications or prior treatments.
Method: Biopsy or surgical resection
Laboratory Analysis
The sample is collected via biopsy or surgical resection. The procedure is performed by a qualified healthcare professional.
Report Delivery
The tissue sample is sent to the laboratory. You can resume normal activities immediately after collection.
Timeline: Reports are typically available within 5-7 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Lung Cancer Panel 5 is to detect mutations and rearrangements in the EGFR, KRAS, BRAF, ALK1, and ROS1 genes. These genetic alterations are critical in the pathogenesis of lung cancer and serve as predictive biomarkers for targeted therapies. For example, EGFR mutations predict response to EGFR-TKIs like erlotinib and osimertinib, while ALK and ROS1 rearrangements indicate sensitivity to crizotinib and other ALK/ROS1 inhibitors. KRAS and BRAF mutations help in prognosis and guide treatment decisions, including potential resistance mechanisms. This panel is essential for personalized treatment planning, avoiding ineffective chemotherapy, and identifying patients who may benefit from newer targeted agents or clinical trials.
How to Prepare
- Tissue sample must be fixed in formalin and embedded in paraffin
- Provide the paraffin block or unstained slides
- Ensure the sample is labeled with patient identification
- Maintain proper storage conditions to avoid degradation
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This panel is essential for guiding targeted therapy in non-small cell lung cancer. Identifying actionable mutations can significantly improve treatment outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor tissue (<20% tumor content)
- Sample not fixed properly
- Sample with extensive necrosis
- Incorrect labeling or missing requisition form
Understanding Your Results
EGFR mutation detected
Likely to benefit from EGFR-TKIs (e.g., osimertinib, erlotinib)
KRAS mutation detected
May not respond to EGFR-TKIs; consider other therapies
BRAF V600E mutation
Potential benefit from BRAF inhibitors (e.g., dabrafenib) combined with MEK inhibitors
ALK rearrangement
Likely to benefit from ALK inhibitors (e.g., crizotinib, alectinib)
ROS1 rearrangement
Likely to benefit from ROS1 inhibitors (e.g., crizotinib, entrectinib)
No mutations detected
No actionable mutations in these genes; consider other testing or chemotherapy
Consult your oncologist if you have been diagnosed with lung cancer and are considering targeted therapy. Also, seek medical advice if you experience persistent cough, chest pain, hemoptysis, or unexplained weight loss.
Limitations
- ⚠Only detects mutations in the five specified genes
- ⚠May miss rare or novel mutations
- ⚠Requires sufficient tumor content (at least 20%)
- ⚠Results are qualitative and not quantitative
- ⚠Not a screening test for early detection
Risks & Considerations
- ●Risks are associated with the biopsy procedure, not the test itself
- ●Possible bleeding or infection at biopsy site
- ●Rare complications from anesthesia if used
Interfering Factors
- ●Inadequate tumor tissue sample
- ●Poor DNA quality due to prolonged fixation
- ●Decalcification of bone samples may degrade DNA
- ●Contamination with normal tissue
- ●Prior chemotherapy or radiation may alter mutation profile
Compare With Similar Tests
| Test | Lung Cancer Panel 5 (EGFR,KRAS,BRAF,ALK1,ROS1) | Lung Cancer Panel 3 (EGFR, ALK, ROS1) | Comprehensive Genomic Profiling (CGP) | Single Gene EGFR Mutation Test |
|---|---|---|---|---|
| Comparison | Lung Cancer Panel 5 (EGFR,KRAS,BRAF,ALK1,ROS1) |
Frequently Asked Questions
What is the cost of the Lung Cancer Panel 5 test?
What sample is required for this test?
Is fasting required before the test?
How long does it take to get results?
What genes are analyzed in this panel?
Who should get this test?
Is a doctor's prescription required?
Can this test be done on a blood sample?
What is the turnaround time?
Is home sample collection available?
What does a positive EGFR mutation mean?
Are there any risks associated with the test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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