MAF/IgH (MM) Test
Short Name: MAF/IgH
Also known as: MAF/IgH Translocation Test, Multiple Myeloma FISH Panel, MAF Gene Rearrangement Test
MAF/IgH (MM) Test test available at DNA Labs India for ₹5,250. Uses Fluorescence In Situ Hybridization (FISH) on Bone Marrow / Peripheral Blood samples. Results in Reports are typically available within 3-4 days after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the MAF/IgH (MM) test is to detect specific chromosomal rearrangements involving the MAF gene and the IgH locus, which are critical in the pathogenesis and prognosis of multiple myeloma. Identifying these translocations helps clinicians determine the risk category of the disease, predict response to therapy, and monitor minimal residual disease. This information is essential for personalizing treatment plans and improving survival rates.
- Test Code
- 6126
- CPT Code
- 88271, 88275, 88291
- ICD Code
- C90.0
- Price
- ₹5,250
- Sample Type
- Bone Marrow / Peripheral Blood
- Result Time
- Reports are typically available within 3-4 days after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation is required. However, a doctor's prescription is mandatory. Inform your doctor about any medications you are taking, especially anticoagulants or chemotherapy agents.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
A blood sample will be drawn from a vein in your arm, or a bone marrow aspiration will be performed by a healthcare professional. The procedure is quick and may cause mild discomfort.
Report Delivery
You can resume normal activities immediately. If bone marrow aspiration was performed, you may experience soreness at the site; apply ice and take pain relievers as advised by your doctor.
Timeline: Reports are typically available within 3-4 days after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the MAF/IgH (MM) test is to detect specific chromosomal rearrangements involving the MAF gene and the IgH locus, which are critical in the pathogenesis and prognosis of multiple myeloma. Identifying these translocations helps clinicians determine the risk category of the disease, predict response to therapy, and monitor minimal residual disease. This information is essential for personalizing treatment plans and improving survival rates.
How to Prepare
- Sample type: Bone Marrow or Peripheral Blood
- Container: Sodium Heparin Vacutainer (2 ml)
- Transport: Maintain at ambient temperature (15-25°C)
- Do not freeze the sample
- Label the sample with patient's name and date of collection
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The MAF/IgH translocation is a high-risk cytogenetic abnormality in multiple myeloma. Early detection via FISH helps risk stratification and guides targeted therapy, improving patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted sample
- Incorrect container (e.g., EDTA tube)
- Sample received after 48 hours of collection
- Unlabeled or mislabeled sample
Understanding Your Results
Negative
No MAF/IgH translocation detected. This suggests a standard-risk profile, but other cytogenetic abnormalities may still be present.
Positive
MAF/IgH translocation detected. This is associated with high-risk multiple myeloma, and aggressive therapy may be recommended.
If you have been diagnosed with multiple myeloma or are experiencing symptoms such as bone pain, fatigue, recurrent infections, or unexplained weight loss, consult your oncologist to determine if the MAF/IgH (MM) test is appropriate for you.
Limitations
- ⚠FISH only detects specific translocations; other genetic abnormalities may not be identified
- ⚠Results should be interpreted in conjunction with clinical findings and other laboratory tests
- ⚠Test may not detect low-level clones if tumor burden is low
- ⚠Not a screening test for the general population
Risks & Considerations
- ●Minimal risk of bleeding or bruising at the puncture site
- ●Rare risk of infection at the collection site
- ●Discomfort during bone marrow aspiration
Interfering Factors
- ●Hemolyzed or clotted samples may affect test accuracy
- ●Insufficient sample volume
- ●Prior chemotherapy or radiation may alter cytogenetic results
- ●Delayed processing of sample beyond 24 hours
Compare With Similar Tests
| Test | MAF/IgH (MM) | MAF/IgH (MM) | IgH/FGFR3 (t(4;14)) | TP53 Deletion |
|---|---|---|---|---|
| Comparison | MAF/IgH (MM) |
Frequently Asked Questions
What is the MAF/IgH (MM) test?
Why is the MAF/IgH (MM) test important?
What sample is required for the MAF/IgH (MM) test?
Is fasting required before the MAF/IgH (MM) test?
How long does it take to get the results?
What is the cost of the MAF/IgH (MM) test in India?
Is a doctor's prescription required for this test?
What does a positive MAF/IgH result mean?
Can this test be done during pregnancy?
Is home sample collection available?
Are there any risks associated with the test?
How should I prepare for the test?
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